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Colorectal cancer (CRC): Dr.Mohammad Shaikhani. MBChB/CABM/FRCP .
CRC:PRECURSORS ,[object Object],[object Object],[object Object],[object Object]
CRC:PRECURSORS ,[object Object],[object Object],[object Object],[object Object]
CRC:TSG mutations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CRC:  MMR Mutations   ,[object Object],[object Object],[object Object],[object Object]
CRC:IBD-associated mutations ,[object Object]
CRC precursors: Key points ,[object Object],[object Object],[object Object]
Epidemiology/risk factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hereditary CRC Syndromes:FAP ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hereditary CRC Syndromes: attenuated FAP ,[object Object],[object Object]
Hereditary CRC Syndromes: HNPCC ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hereditary CRC Syndromes: CRC family history ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Stratification of Colorectal Cancer Risk Lifetime Risk Risk Level High 100 % Presence of familial adenomatous polyposis 10% Presence of hereditary nonpolyposis colorectal cancer Moderate 20% Presence of chronic colitis due to ulcerative colitis or Crohn's colitis 10-20% Familial: First-degree relative with colorectal cancer Average (negative family history ) 5-6% >50 years of age
IBD: ,[object Object],[object Object],[object Object],[object Object]
Factors Associated with the Development of CRC Protective Factors Risk Factors No family history of colorectal cancer or an inherited colorectal cancer syndrome Family history of colorectal cancer or an inherited colorectal cancer syndrome Birth in Asia or Africa Personal history of inflammatory bowel disease Diet high in fruits and vegetables * Birth in North America or Northern Europe Regular aerobic exercise Diet high in red meat, sucrose, fat Calcium and folate supplementation Physical inactivity Lack of dietary calcium and folate Obesity Smoking Excessive alcohol intake Cholecystectomy
Primary prevention& screening: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Algorithm for screening for CRC
Patient selection for screening: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Patient selection for screening: ,[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Staging of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of CRC: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of CRC: ,[object Object],[object Object],[object Object],[object Object]
Prognosis of CRC: ,[object Object],[object Object],[object Object],[object Object]
Prognosis of CRC: ,[object Object],[object Object],[object Object]
 
 
The Difference between a Normal Colon and a Colon with Cancer

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GIT CRC 2010 Plus pictures.

  • 1. Colorectal cancer (CRC): Dr.Mohammad Shaikhani. MBChB/CABM/FRCP .
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.  
  • 14. Stratification of Colorectal Cancer Risk Lifetime Risk Risk Level High 100 % Presence of familial adenomatous polyposis 10% Presence of hereditary nonpolyposis colorectal cancer Moderate 20% Presence of chronic colitis due to ulcerative colitis or Crohn's colitis 10-20% Familial: First-degree relative with colorectal cancer Average (negative family history ) 5-6% >50 years of age
  • 15.
  • 16. Factors Associated with the Development of CRC Protective Factors Risk Factors No family history of colorectal cancer or an inherited colorectal cancer syndrome Family history of colorectal cancer or an inherited colorectal cancer syndrome Birth in Asia or Africa Personal history of inflammatory bowel disease Diet high in fruits and vegetables * Birth in North America or Northern Europe Regular aerobic exercise Diet high in red meat, sucrose, fat Calcium and folate supplementation Physical inactivity Lack of dietary calcium and folate Obesity Smoking Excessive alcohol intake Cholecystectomy
  • 17.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30.  
  • 31.  
  • 32. The Difference between a Normal Colon and a Colon with Cancer