Ketosteril.pptx

Ketosteril
Alpha Keto Analog Tablets
Dr Mya That Mon
Product Manager
Care Mandalay Co.,ltd.
TREY
research
Challenges of CKDPatients
• In 2017, prevalence of CKD become 843,6 million
people world wide
• In 2017, it is 12th leading cause of death
• It is predicted to become 5th leading cause of death in
2040
Prevalence
• It cause large burden in low and middle income
countries
• CKD has devastating consequences.
• We should develop preventative and therapeutic
measures that are effective.
• To lower the incidence of CKD and slow it progress.
2
Epidemiology of CKD : update 2022. Kovesdy, 2022
Challenges
TREY
research
Challenges inAdvancedCKDwithProteinRestrictedPatients
• Protein energy wasting
• Malnutrition
• Decrease appitite
• Infection
• Cardiovascular disease
Effect
• The prevalence of protein-energy wasting in early to
moderate CKD is 20–25% and increases as CKD
progresses
3
Kovesdy, C. P., Kopple, J. D., & Kalantar-Zadeh, K. (2013). Management of protein-energy wasting in non-dialysis-dependent
chronic kidney disease: reconciling low protein intake with nutritional therapy. The American Journal of Clinical Nutrition,
97(6), 1163–1177
Prevalence
Low Protein Diet with Ketosteril can delay onset of
Dialysis and reduced MACCEs
MACCEs = major adverse cardiac and cerebrovascular events
Yen et al. Advanced Chronic Kidney Disease with Low and Very Low GFR: Can a Low-Protein Diet Supplemented with
Ketoanalogues Delay Dialysis?. Nutrients. 2020
Reduce anorexia
sensation
Increase
body
weight
and BMI
Improve
overall
nutritional
status
Benefits of Ketosteril
• Aparicio, M., Bellizzi, V., Chauveau, P., Cupisti, A.,
Ecder, T., Fouque, D., … Yu, X. (2012). Protein-
Restricted Diets Plus Keto/Amino Acids - A Valid
Therapeutic Approach for Chronic Kidney Disease
Patients. Journal of Renal Nutrition, 22(2), S1–S21
Serum
albumin
level
Reduce
Proteinuria
Risk of
ESRD
Further
reduce
CVD and
Hf
Benefits of Ketosteril
• De Zeeuw, D. (2004). Albuminuria, a Therapeutic Target for Cardiovascular Protection in Type 2 Diabetic Patients With Nephropathy.
Circulation, 110(8), 921–927
Many Clinical Papers of Ketosteril
BP control is improve and significantly
reduce proteinuria
KA can reduce risk of initiating
long term dialysis. It can also slow
down the progression of CKD
Many Clinical Papers of Ketosteril
Delay dialysis and improve metabolic
abnormalities
DOSAGE
• 1 tablet/ 5 kg body weight
• During meal
• Swallow whole
SIDE EFFECT
• Hypercalcaemia
• Mornitor serum Calcium level
Founded since 1912 in Bad Homburg, Germany
Fresenius Kabi is a global healthcare company
specializes in clinical nutrition such as enteral and parenteral
nutrition products and lifesaving medicines and technologies for
infusion, transfusion
Fresenius Kabi operate in 85 countries world wide including Europe, North America,
Latin America, Asia Pacific and Africa
SUMMARY
• Ketosteril can replace essential amino acid and minimize
nitrogen waste
• Ketosteril can delay dialysis and improve nutritional
status
• Ketosteril is produce by Fresenius kabi, Germany based
pharmaceutical company so the product quality is assured
1 de 13

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Ketosteril.pptx

  • 1. Ketosteril Alpha Keto Analog Tablets Dr Mya That Mon Product Manager Care Mandalay Co.,ltd.
  • 2. TREY research Challenges of CKDPatients • In 2017, prevalence of CKD become 843,6 million people world wide • In 2017, it is 12th leading cause of death • It is predicted to become 5th leading cause of death in 2040 Prevalence • It cause large burden in low and middle income countries • CKD has devastating consequences. • We should develop preventative and therapeutic measures that are effective. • To lower the incidence of CKD and slow it progress. 2 Epidemiology of CKD : update 2022. Kovesdy, 2022 Challenges
  • 3. TREY research Challenges inAdvancedCKDwithProteinRestrictedPatients • Protein energy wasting • Malnutrition • Decrease appitite • Infection • Cardiovascular disease Effect • The prevalence of protein-energy wasting in early to moderate CKD is 20–25% and increases as CKD progresses 3 Kovesdy, C. P., Kopple, J. D., & Kalantar-Zadeh, K. (2013). Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy. The American Journal of Clinical Nutrition, 97(6), 1163–1177 Prevalence
  • 4. Low Protein Diet with Ketosteril can delay onset of Dialysis and reduced MACCEs MACCEs = major adverse cardiac and cerebrovascular events Yen et al. Advanced Chronic Kidney Disease with Low and Very Low GFR: Can a Low-Protein Diet Supplemented with Ketoanalogues Delay Dialysis?. Nutrients. 2020
  • 5. Reduce anorexia sensation Increase body weight and BMI Improve overall nutritional status Benefits of Ketosteril • Aparicio, M., Bellizzi, V., Chauveau, P., Cupisti, A., Ecder, T., Fouque, D., … Yu, X. (2012). Protein- Restricted Diets Plus Keto/Amino Acids - A Valid Therapeutic Approach for Chronic Kidney Disease Patients. Journal of Renal Nutrition, 22(2), S1–S21
  • 6. Serum albumin level Reduce Proteinuria Risk of ESRD Further reduce CVD and Hf Benefits of Ketosteril • De Zeeuw, D. (2004). Albuminuria, a Therapeutic Target for Cardiovascular Protection in Type 2 Diabetic Patients With Nephropathy. Circulation, 110(8), 921–927
  • 7. Many Clinical Papers of Ketosteril BP control is improve and significantly reduce proteinuria KA can reduce risk of initiating long term dialysis. It can also slow down the progression of CKD
  • 8. Many Clinical Papers of Ketosteril Delay dialysis and improve metabolic abnormalities
  • 9. DOSAGE • 1 tablet/ 5 kg body weight • During meal • Swallow whole
  • 10. SIDE EFFECT • Hypercalcaemia • Mornitor serum Calcium level
  • 11. Founded since 1912 in Bad Homburg, Germany Fresenius Kabi is a global healthcare company specializes in clinical nutrition such as enteral and parenteral nutrition products and lifesaving medicines and technologies for infusion, transfusion
  • 12. Fresenius Kabi operate in 85 countries world wide including Europe, North America, Latin America, Asia Pacific and Africa
  • 13. SUMMARY • Ketosteril can replace essential amino acid and minimize nitrogen waste • Ketosteril can delay dialysis and improve nutritional status • Ketosteril is produce by Fresenius kabi, Germany based pharmaceutical company so the product quality is assured