DEVELOPMENT OF THE UMBILICAL CORD
The umbilical cord is formed when the body stalk and
the ductus omphalo-entericus (vitelline duct, a long
narrow tube that joins the yolk sac to the midgut lumen
of the developing fetus) as well as the umbilical coelom (
part of mesoderm)are enveloped by the spreading
amnion between the 4th and 8th week. Finally, when the
membranes of the amniotic cavity come into contact
with those of the chorionic cavity and the two extra-
embryonic mesoderm layers that cover both
membranes, fuse. With the flexing movements of the
embryo, the amnion encircles the body stalk, the ductus
omphalo-entericus and the umbilical vessels, thus
circumscribing the elements of the umbilical cord.
A. body stalk
B. stem of umbilical vesicles
1.Amniotic cavity
2.Umbilical vesicle
3.Chorionic cavity
4.Villous chorion
5.Allantois
Body stalk at around the
3rd week
Formation of the umbilical cord at
around the 3.5th week
A. Body stalk
B. Stem of umbilical vesicle
C. Umbilical cord
1.Amniotic cavity
2.Umbilical vesicle
3.Chorionic cavity
4. Chorion leave
Umbilical cord :The body stalk and
the yolk stalk are now united and
form the umbilical cord. Through
increasing secretion of amniotic fluid
the chorionic cavity becomes
obliterated. Here at around the 4-5th
week: The chorionic cavity is reduced
in size
Umbilical vesicle in the chorionic cavity: Flexing of
the embryo at around the 8th week with expansion
of the amnion that encircles the body stalk and the
ductus omphalo-entericus, the umbilical coelom
and the umbilical vessels
In the early stage (at around the 8th week) the umbilical
cord is in the form of a very thick and short section with
the following structures:
The ductus omphalo-entericus which connects the
primitive intestines with the umbilical vesicle and two
vitelline vessels (vasa omphalomesenterica, 2 arteries and
2 veins). The umbilical vesicle is located in the chorionic
cavity (exocoelom = extra-embryonic coelom).
The body stalk with the allantois, the umbilical vessels (2
arteries and 1 vein). During the development it gets shifted
ventrally in order to finally fuse with the stem of the
umbilical vesicle.
The umbilical coelom that connects the extra-embryonic
coelom with the intra-embryonic coelom
1. Ductus omphalo-entericus
2.Extra-embryonic coelom
(umbilcal coelom)
3. Allantois
4. Umbilical vein
5. Umbilical arteries
6. Amnion
7.Intestinal tube(physiologic umbilical hernia)
8.Vasa omphalomesenterica
Transversal section of the primitive
umbilical cord after approximately 8
weeks
Transversal section of the primitive
umbilical cord with physiologic
umbilical hernia at around the 3rd
month
Further development promotes both lengthening as well as
the reduction of some structures.
Lengthening:
The amniotic cavity forms a covering around the ductus
omphalo-entericus and the body stalk, which elongates. The
newly formed umbilical cord continues to lengthen to allow
for fetal movements and coils in the amniotic cavity.
Reduction:
Numerous elements degenerate in the 3rd month.
the omphalo-enteric duct (it can remain in the form of a
Meckel's diverticulum)
the umbilical vesicle of the allantois (it is obliterated in
order to form the umbilical ligament, lying medially in
adults)
the vitelline circulation system in the extra-embryonic
region.
the umbilical coelom, which clumps and disappears.
Finally, only the body stalk remains with its umbilical
vessels (2 arteries, 1 vein), which are surrounded by an
amniotic epithelial layer. The connective tissue of the
body stalk and the amnion (that stems from the extra-
embryonic mesoblast) go over into a common umbilical
cord connective tissue, the so-called "Wharton jelly", an
elastic and resistant tissue that protects the umbilical
vessels from possible mechanical pressure and creasing.
UMBILICAL CORD
Length of cord varies from no cord (achordia) to 300 cm
with up to 3 cm diameters(average 55cm) sufficient to
allow delivery of baby without traction to placenta.
-Transmits umbilical blood vessels
-Two arteries from internal iliac artery, unoxygenated
blood and one vein from Ductus venosus having
oxygenated blood.
the extracellular matrix → Wharton jelly.
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ABNORMALITIES
Less than 40 cm short cord
Very long cord may wrapped around neck or body of
fetus or become knotted
True knots result occlusion of blood vessels
False knots
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THE UMBILICAL CORD PATHOLOGY
A. Abnormalities of development
B. Accidental pathology
A. ABNORMALITIES OF DEVELOPMENT
abnormalities of cord insertion
-marginal insertion
-velamentous insertion
abnormalities in cord length
tumors of umbilical cord
vascular anomalies (single
umbilical artery)
ABNORMALITIES OF CORD INSERTION
Velamentous insertion –
vasa praevia
Fetal vessels run in the membranes below the presenting
fetal part.
Spontaneous / artificial rupture of membranes - rupture
the vessels - fetal exsanguination – Benkiser
syndrome.
Hypoxia if the vessels are compressed between baby
and birth canal.
Fetal mortality - 33-100%, if not dg. prenatally.
ABNORMALITIES IN CORD LENGTH
Normal 55 cm
1. Cord absence (achordia)
2. Excessively short umbilical
cord (< 35cm)
abnormal presentations
fetal heart rate injuries
abruptio placenta
rupture → hemorrhage → fetal death
anomalies of parturition
inversion of the uterus.
ABNORMALITIES IN CORD
LENGTH
3. Excessive length (cord length >
70cm)
vascular occlusion (thrombi)
true knots
cord prolapse
loops of the cord.
B. ACCIDENTAL PATHOLOGY
loops
knots
prolapse
thrombosis
ruptures
eventualities which lead to umbilical
vessels compression and fetal distress.
Umbilical cord knots
True knots - distinguished from false
knots (varicosities or accumulations of
Wharton's jelly) ► no clinical
significance
True knots result from active fetal
movements (1.1 % of births).
UMBILICAL CORD PROLAPSE
Types of umbilical cord prolapse
1. occult cord prolapse
2. overt cord prolapse
3. funic presentation = cord
presentation = procubitus.
Overt cord prolapse is always associated with rupture
of the membranes and displacement of the cord into the
vagina, often throughout the introitus.
UMBILICAL CORD PROLAPSE
Ruptured membranes
occult cord prolapse (descent of the
umbilical cord alongside)
overt cord prolapse (umbilical cord
past the presenting part).
UMBILICAL CORD PROLAPSE
NO ruptured membranes
Funic presentation = cord
presentation = procubitus →
one or more loops of umbilical
cord between the fetal presenting
part and the cervix,.
If the cervix is opened the cord can be
easily palpated through the
membranes.