1. Silencing inhibitor of cell replication spurs insulinproducing beta cells to reproduce
Persistent HIV replication associated with lower drug
concentrations in lymphatic tissues
SUSANA MEJÍA MESA
MEDICAL STUDENT
III SEMESTER

4. INTRODUCTION
Cell replication is one of the most important
process and it has a huge intervention in many
disease.
An error in cell replication can be catastrophic.
Many researches are towards investigating cell
replication because if they know enough information
about it, it will be possible to alter it in a positive
way and help in many disease

5. Silencing inhibitor of cell replication spurs insulinproducing beta cells to reproduce
Perelman School of Medicine at the University of Pennsylvania January 16 2014
Scientist have studied patients with hyperinsulinisim
of infancy and tried to relate it in diabetic patients
(type 1 and 2) looking for a way to stimulate
pancreatic beta cells.

6. Silencing inhibitor of cell replication spurs insulinproducing beta cells to reproduce
Perelman School of Medicine at the University of Pennsylvania January 16 2014
P57
Is a protein in charge of cellcycle inhibition in pancreatic
beta cells. Babies born with
hyperinsulinemia don't have
P57 active in all cells
P57
P57

7. Silencing inhibitor of cell replication spurs insulinproducing beta cells to reproduce
Perelman School of Medicine at the University of Pennsylvania January 16 2014
In the research scientist
discovered that if they
inhibit P57 on a diabetic
patient cell and infect
the cells in a diabetic
mouse, there will be an
amount in the
production on insulin
P57
P57
Diabetic
Diabetic
cell
cell
insulin
insulin
insulin
insulin
insulin
insulin

8. Silencing inhibitor of cell replication spurs insulinproducing beta cells to reproduce
Perelman School of Medicine at the University of Pennsylvania January 16 2014
The study proved the
possibility of altering the
replication process and
inhibiting P57 in mice,
the next step is being
able to get the same
effect in humans.
P57
P57
Diabetic
Diabetic
cell
cell
insulin
insulin
insulin
insulin
insulin
insulin

9. I find this research very encouraging for future
investigations, if it is correct and possible to alter P57
replication and stimulate insulin production we would be
speaking of a cure to diabetes. It would mean a huge
discovery for mankind and it would improve the life of
many patients suffering this disease
Personal comment

10. Persistent HIV replication associated with lower drug
concentrations in lymphatic tissues
University of Minnesota Academic Health Center January 22 2014
Currently there are a big amount
of medication for treating specific
illness.
In the investigation scientist
expose that even thought the
medication used in treating HIV
is efficient because patients live
longer it doesn't have a complete
effect.

11. Persistent HIV replication associated with lower drug
concentrations in lymphatic tissues
University of Minnesota Academic Health Center January 22 2014
In the investigation, it is
explained that some medication
used in HIV treatment is not
working completely. Even
though blood concentrations of
this drug are high, when
scientist looked for drug
concentration in lymph tissue it
was low.

12. Persistent HIV replication associated with lower drug
concentrations in lymphatic tissues
University of Minnesota Academic Health Center January 22 2014
The fact that Lymph tissue
concentrations are low mean
that the cells in this tissue
don't have enough medication
to stop cell replication
completely, so the treatment
is ineffective.

13. Persistent HIV replication associated with lower drug
concentrations in lymphatic tissues
University of Minnesota Academic Health Center January 22 2014
This study will also affect
some pharmaceutical
business, because it
encourages them to create
medication that is actually
penetrating the important
zones were there biggest
amount of HIV cells are.

14. Personal comment
There is a huge importance and medical utility
in news as this. The discoveries made open
many doors in HIV treatment and will mean a
huge benefit for patients and families involved
in this disease.
This study also motivates other studies which
can deepen in cell replication not only to boost
treatments but to look for alternative cures.

15. Medical utility
All investigations which have as a purpose
to search for new treatment, improve old
treatment or look for possible cures are
always going to be extremely useful
articles, not only for patients but to
families and all mankind.

16. Medical utility
As it is exposed in the articles, the
discoveries made in both investigations
can lead to more effective treatment and
even to the production of a possible cure.
It will be necessary to do many more
investigations, especially towards cell
replication because it represents one of
the most important factors in diagnosis,
treatment and cure.

17. Medical utility
The discoveries in HIV treatment will lead
to a whole new perspective.
Pharmaceutical business will change some
components from the treatment and make
it more permeable in cells. If they conquer
a medication that can enter easily in
infected cells the efficacy of the treatment
will be bigger.

18. Medical utility
The possibility to try to cure diabetes is
something beyond imaginable. And what is
even more astonishing is the possibility of
changing patient´s own cells.
To be able to speak of a cure in diabetes
means that 347 million´s peoples lives will
be changed (OMS).

19. Bibliography
 Perelman School of Medicine at the University
of Pennsylvania (2014, January 16). Silencing
inhibitor of cell replication spurs insulinproducing beta cells to reproduce. Science daily.
Retrieved February 13, 2014. from
http://www.sciencedaily.com/releases/2014/01/1
40116162107.htm
 University of Minnesota Academic Health
Center (2014, January 22). Persistent HIV
replication associated with lower drug
concentrations in lymphatic tissues. Science daily.
Retrieved February 13, 2014 . From
http://www.sciencedaily.com/releases/2014/01/1
40122153917.htm

20. THANK YOU