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Understanding Equine Ulcers &
       Gastric Health
              Lydia F. Gray, DVM
       Medical Director/Staff Veterinarian
              Jessica Normand
      Senior Director – SmartSupplements™

                  July 18, 2012
Your Presenters




     SmartPak.com
Agenda
    •   What are gastric ulcers?
    •   Risk Factors
    •   Signs
    •   Diagnosis
    •   Treatment & Prevention




3
                           SmartPak.com
Gastric Ulcer Statistics
 It has been well-documented that as many as 90% of
  racehorses and nearly 60% of active show horses have
  gastric ulcers.

 Simulated conditions representing activities typical in the
  recreational use of horses were determined to cause
  gastric ulcers in as little as five days.

                  McClure SR, Carithers DS, Gross SJ, Murray MJ.
       Gastric ulcer development in horses in a simulated show or training
                                  environment.
                  J Am Vet Med Assoc. 2005 Sep;227(5):775-777.
4
                                       SmartPak.com
What are gastric ulcers?
• Gastric = stomach
• Ulcer = erosion
• Equine Gastric Ulcer Syndrome (EGUS)




5
       Illustration courtesy of Rick Gore Horsemanship, ThinkLikeAHorse.org
A horse in his natural state…




      Grazes almost 20 hours per day

6
                  SmartPak.com
Risk Factors for Gastric Ulcers
    •       Diet
        –     Infrequent hay feeding
        –     High grain diets

            “Feeding horses more than five pounds of grain every
                  five to six hours can cause gastric ulcers.”
                          -Frank Andrews, DVM, MS, DACVIM
                              Louisiana State University




7
                                     SmartPak.com
Risk Factors for Gastric Ulcers
    •   Intense exercise




8
                           SmartPak.com
Risk Factors for Gastric Ulcers
    •       Stress
        –     Training/competition
        –     Transportation
        –     Schedule changes
        –     Injury or illness




9
                                SmartPak.com
Risk Factors for Gastric Ulcers
     •   Excessive use of NSAIDS




10
                           SmartPak.com
Signs of Gastric Ulcers
     •       Physical
         –     Mild, recurring colic
         –     Weight loss
         –     Poor appetite
         –     Dull hair coat




11
                                   SmartPak.com
Signs of Gastric Ulcers

 •       Behavioral
     –     Poor attitude
     –     Irritability
     –     Resistance
     –     Dullness




12
                           SmartPak.com
Signs of Gastric Ulcers
•        Performance
     –     Lead swapping
     –     Reluctance to bend/collect
     –     Hitting jumps
     –     Slower times
     –     Lack of energy




13
                               SmartPak.com
Signs of Gastric Ulcers
•        None
     –    Subclinical
     –    “Silent”




14
                          SmartPak.com
Diagnosis of Gastric Ulcers
     •   History
     •   Signs
     •   Endoscopy
     •   Response to treatment




15
                          SmartPak.com
Diagnosis of Gastric Ulcers




Reproduced from
Andrews F, Bernard W,
Byars D, Cohen N, Divers
T, MacAllister C, et al.
Recommendations for
the diagnosis and
treatment of equine
gastric ulcer syndrome
(EGUS). Equine Vet Educ
1999; 1 (2): 122-134.

16
Treatment & Prevention of Gastric Ulcers
• Goal is to create a permissive environment in the
  stomach for tissue healing, which requires a
  combined approach:
   1. Pharmacologic agents
   2. Natural agents
   3. Dietary changes
   4. Management changes


17
                       SmartPak.com
Treatment & Prevention of Gastric Ulcers
1. Pharmacologic Agents
     – Proton pump inhibitors (FDA-approved)
        • GastroGard® (Rx)
        • UlcerGard®(OTC)

     – Histamine type 2 receptor antagonists
        • Cimetidine (Rx)
        • Ranitidine (Rx)




18
                             SmartPak.com
Treatment & Prevention of Gastric Ulcers

     2. Natural Agents
       – Antacids
       – Amino acids
       – Herbs
       – Others




19
                         SmartPak.com
Natural Agents: Antacids
• Calcium, magnesium, aluminum




Clark CK, Merritt AM, Burrow JA, Steible CK. Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth
             subsalicylate on gastric pH in horses. J Am Vet Med Assoc. 1996 May 15;208(10):1687-1691.

Murray MJ, Grodinsky C. The effects of famotidine, ranitidine and magnesium hydroxide/aluminum hydroxide on gastric
                          fluid pH in adult horses. Equine Vet J Supple. 1992 Feb;(11):52-55.

20
                                                     SmartPak.com
Natural Agents: Amino Acids
• Glutamine, threonine, glycine, collagen




Zhong Z, Wheeler MD, Li X, et al. L-Glycine: a novel anti-inflammatory, immunomodulatory, and cytoprotective agent.
                              Curr Opin Clin Nutri Metab Care. 2003 Mar;6(2):229-240.

Noe JE. L-Glutamine use in the treatment and prevention of mucositis and cachexia: a naturopathic perspective. Integr
                                       Cancer Ther. 2009 Dec;8(4)): 409-415.

21
                                                      SmartPak.com
Natural Agents: Herbs
 • Licorice, marshmallow root, slippery elm, aloe vera,
   adaptogens, seabuck thorn




Aly AM, Al-Alousi L, Salem HA. Licorice: a possible anti-inflammatory and anti-ulcer drug. AAPS PharmSci
                                      Tech, 2—5 Sep 20;6(1):E74-82.

Lee EB, Kim OJ, Kang SS, Jeong C. Araloside A, an anti-ulcer constituent from the root bark of Aralia elata.
22
                                Biol Pharm Bull. 2005 Mar;28(3):523-526.
                                                        SmartPak.com
Natural Agents: Others
   • Pectin, lecithin, silica, gamma oryzanol




    Ferrucci F, Zucca E, Croci C, et al. Treatment of gastric ulceration in 10 Standardbred Racehorses
                 with a pectin-lecithin complex. Vet Rec. 2003 May 31;152(22):679-681.

   Venner M, Lauffs S, Deegen E. Treatment of gastric lesions in horses with pectin-lecithin complex.
23
                              Equine Vet J Suppl. 1999 Apr;(29):91-96.
                                                       SmartPak.com
Treatment & Prevention of Gastric Ulcers
3. Dietary Changes
      –   Provide constant access to good-quality hay
      –   Or, provide hay frequently throughout the day
      –   Offer alfalfa hay, if possible
      –   Limit the amount of grain
      –   Or, feed grain in small, more frequent meals




24
                                 SmartPak.com
Treatment & Prevention of Gastric Ulcers
4. Management Changes
      –   Give “down time” from competition, travel
      –   Provide pasture turn out, with “buddy” if possible
      –   Keep a regular schedule
      –   Reduce stress




25
                                  SmartPak.com
Questions & Answers




        SmartPak.com
Questions
1.   What is the best way to manage a horse with ulcers on very limited pasture?
     Is one type of hay better than another for a horse with ulcers?
2.   Once you treated the ulcer with something like GastroGard for 30 days, what
     is the best on-going prevention so that you don't have to incur the costly
     treatment of GastroGard?
3.   What effects does heavy training have on ulcers if the horse already has them,
     and is it a cause of them?
4.   Does cribbing have anything to do with ulcers?
5.   Once a horse has been diagnosed with an ulcer, does treatment cause the
     ulcer to go away, or merely the symptoms being presented for the ulcer?
6.   My horse's ulcers seem much better when he is on grass versus hay. Any
     research that confirms this?




                                      SmartPak.com                             27
Questions
7.  I've a 14 y.o. welsh x qtr pony leased to a therapy program. I understand
    performance horses are prone to ulcers but are lesson horses also prone? Can
    light work cause ulcers? Or not enough work? We're at 1 week with my pony
    on SmartGut and Ranitidine. Any other suggestions?
8. Is it true that horses that are on a bit of supplements are prone to colic and
    ulcers?
9. I have a mare that "tummy aches" not a true colic; she acts achy only after she
    eats. The vet said it is was 90% chance it was ulcers due to a high amount of
    grain, stall time and performance time. What types of feed can I give her to
    reduce this affect?
10. My horse was scoped and diagnosed with gastric ulcers. He was treated for
    the recommended time and dosage of GastroGard. Should I have him re-
    scoped to ensure the ulcers are gone?




                                     SmartPak.com                             28
Questions
11. How long can a horse go without hay between meals and still be safe from
    ulcers? A couple of hours?
12. GastroGard vs. UlcerGard
13. Any relationship between a bacteria and an ulcer like in people?




                                   SmartPak.com                                29
Thank you for attending our Webinar!
        Please visit us at SmartPak.com,
 email us at CustomerCare@SmartPak.com
or call us at 1-800-461-8898 if we can answer
               any further questions.
                                  ~ Your Friends at SmartPak




                   SmartPak.com

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SmartPak's Understanding Equine Ulcers & Gastric Health

  • 1. Understanding Equine Ulcers & Gastric Health Lydia F. Gray, DVM Medical Director/Staff Veterinarian Jessica Normand Senior Director – SmartSupplements™ July 18, 2012
  • 2. Your Presenters SmartPak.com
  • 3. Agenda • What are gastric ulcers? • Risk Factors • Signs • Diagnosis • Treatment & Prevention 3 SmartPak.com
  • 4. Gastric Ulcer Statistics  It has been well-documented that as many as 90% of racehorses and nearly 60% of active show horses have gastric ulcers.  Simulated conditions representing activities typical in the recreational use of horses were determined to cause gastric ulcers in as little as five days. McClure SR, Carithers DS, Gross SJ, Murray MJ. Gastric ulcer development in horses in a simulated show or training environment. J Am Vet Med Assoc. 2005 Sep;227(5):775-777. 4 SmartPak.com
  • 5. What are gastric ulcers? • Gastric = stomach • Ulcer = erosion • Equine Gastric Ulcer Syndrome (EGUS) 5 Illustration courtesy of Rick Gore Horsemanship, ThinkLikeAHorse.org
  • 6. A horse in his natural state… Grazes almost 20 hours per day 6 SmartPak.com
  • 7. Risk Factors for Gastric Ulcers • Diet – Infrequent hay feeding – High grain diets “Feeding horses more than five pounds of grain every five to six hours can cause gastric ulcers.” -Frank Andrews, DVM, MS, DACVIM Louisiana State University 7 SmartPak.com
  • 8. Risk Factors for Gastric Ulcers • Intense exercise 8 SmartPak.com
  • 9. Risk Factors for Gastric Ulcers • Stress – Training/competition – Transportation – Schedule changes – Injury or illness 9 SmartPak.com
  • 10. Risk Factors for Gastric Ulcers • Excessive use of NSAIDS 10 SmartPak.com
  • 11. Signs of Gastric Ulcers • Physical – Mild, recurring colic – Weight loss – Poor appetite – Dull hair coat 11 SmartPak.com
  • 12. Signs of Gastric Ulcers • Behavioral – Poor attitude – Irritability – Resistance – Dullness 12 SmartPak.com
  • 13. Signs of Gastric Ulcers • Performance – Lead swapping – Reluctance to bend/collect – Hitting jumps – Slower times – Lack of energy 13 SmartPak.com
  • 14. Signs of Gastric Ulcers • None – Subclinical – “Silent” 14 SmartPak.com
  • 15. Diagnosis of Gastric Ulcers • History • Signs • Endoscopy • Response to treatment 15 SmartPak.com
  • 16. Diagnosis of Gastric Ulcers Reproduced from Andrews F, Bernard W, Byars D, Cohen N, Divers T, MacAllister C, et al. Recommendations for the diagnosis and treatment of equine gastric ulcer syndrome (EGUS). Equine Vet Educ 1999; 1 (2): 122-134. 16
  • 17. Treatment & Prevention of Gastric Ulcers • Goal is to create a permissive environment in the stomach for tissue healing, which requires a combined approach: 1. Pharmacologic agents 2. Natural agents 3. Dietary changes 4. Management changes 17 SmartPak.com
  • 18. Treatment & Prevention of Gastric Ulcers 1. Pharmacologic Agents – Proton pump inhibitors (FDA-approved) • GastroGard® (Rx) • UlcerGard®(OTC) – Histamine type 2 receptor antagonists • Cimetidine (Rx) • Ranitidine (Rx) 18 SmartPak.com
  • 19. Treatment & Prevention of Gastric Ulcers 2. Natural Agents – Antacids – Amino acids – Herbs – Others 19 SmartPak.com
  • 20. Natural Agents: Antacids • Calcium, magnesium, aluminum Clark CK, Merritt AM, Burrow JA, Steible CK. Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in horses. J Am Vet Med Assoc. 1996 May 15;208(10):1687-1691. Murray MJ, Grodinsky C. The effects of famotidine, ranitidine and magnesium hydroxide/aluminum hydroxide on gastric fluid pH in adult horses. Equine Vet J Supple. 1992 Feb;(11):52-55. 20 SmartPak.com
  • 21. Natural Agents: Amino Acids • Glutamine, threonine, glycine, collagen Zhong Z, Wheeler MD, Li X, et al. L-Glycine: a novel anti-inflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutri Metab Care. 2003 Mar;6(2):229-240. Noe JE. L-Glutamine use in the treatment and prevention of mucositis and cachexia: a naturopathic perspective. Integr Cancer Ther. 2009 Dec;8(4)): 409-415. 21 SmartPak.com
  • 22. Natural Agents: Herbs • Licorice, marshmallow root, slippery elm, aloe vera, adaptogens, seabuck thorn Aly AM, Al-Alousi L, Salem HA. Licorice: a possible anti-inflammatory and anti-ulcer drug. AAPS PharmSci Tech, 2—5 Sep 20;6(1):E74-82. Lee EB, Kim OJ, Kang SS, Jeong C. Araloside A, an anti-ulcer constituent from the root bark of Aralia elata. 22 Biol Pharm Bull. 2005 Mar;28(3):523-526. SmartPak.com
  • 23. Natural Agents: Others • Pectin, lecithin, silica, gamma oryzanol Ferrucci F, Zucca E, Croci C, et al. Treatment of gastric ulceration in 10 Standardbred Racehorses with a pectin-lecithin complex. Vet Rec. 2003 May 31;152(22):679-681. Venner M, Lauffs S, Deegen E. Treatment of gastric lesions in horses with pectin-lecithin complex. 23 Equine Vet J Suppl. 1999 Apr;(29):91-96. SmartPak.com
  • 24. Treatment & Prevention of Gastric Ulcers 3. Dietary Changes – Provide constant access to good-quality hay – Or, provide hay frequently throughout the day – Offer alfalfa hay, if possible – Limit the amount of grain – Or, feed grain in small, more frequent meals 24 SmartPak.com
  • 25. Treatment & Prevention of Gastric Ulcers 4. Management Changes – Give “down time” from competition, travel – Provide pasture turn out, with “buddy” if possible – Keep a regular schedule – Reduce stress 25 SmartPak.com
  • 26. Questions & Answers SmartPak.com
  • 27. Questions 1. What is the best way to manage a horse with ulcers on very limited pasture? Is one type of hay better than another for a horse with ulcers? 2. Once you treated the ulcer with something like GastroGard for 30 days, what is the best on-going prevention so that you don't have to incur the costly treatment of GastroGard? 3. What effects does heavy training have on ulcers if the horse already has them, and is it a cause of them? 4. Does cribbing have anything to do with ulcers? 5. Once a horse has been diagnosed with an ulcer, does treatment cause the ulcer to go away, or merely the symptoms being presented for the ulcer? 6. My horse's ulcers seem much better when he is on grass versus hay. Any research that confirms this? SmartPak.com 27
  • 28. Questions 7. I've a 14 y.o. welsh x qtr pony leased to a therapy program. I understand performance horses are prone to ulcers but are lesson horses also prone? Can light work cause ulcers? Or not enough work? We're at 1 week with my pony on SmartGut and Ranitidine. Any other suggestions? 8. Is it true that horses that are on a bit of supplements are prone to colic and ulcers? 9. I have a mare that "tummy aches" not a true colic; she acts achy only after she eats. The vet said it is was 90% chance it was ulcers due to a high amount of grain, stall time and performance time. What types of feed can I give her to reduce this affect? 10. My horse was scoped and diagnosed with gastric ulcers. He was treated for the recommended time and dosage of GastroGard. Should I have him re- scoped to ensure the ulcers are gone? SmartPak.com 28
  • 29. Questions 11. How long can a horse go without hay between meals and still be safe from ulcers? A couple of hours? 12. GastroGard vs. UlcerGard 13. Any relationship between a bacteria and an ulcer like in people? SmartPak.com 29
  • 30. Thank you for attending our Webinar! Please visit us at SmartPak.com, email us at CustomerCare@SmartPak.com or call us at 1-800-461-8898 if we can answer any further questions. ~ Your Friends at SmartPak SmartPak.com

Editor's Notes

  1. Add Seabuckthorn here and can even include Dr. Andrews research, so when our product and our research comes out it seems more credible.