solubility enhancement -by pH change & complexation

SEMINAR ON SOLUBILITY ENHANCEMENT BY 1. ALTERATION IN pH OF THE SOLVENT SYSTEM 2. COMLEXATION TECHNIQUES

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[object Object],/39 Lower pKa Stronger the Acid More ionization Higher pKa Stronger the Base More ionization

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[object Object],[object Object],[object Object],/39

[object Object],[object Object],[object Object],[object Object],/39 ,[object Object],pH Solubility mg/ml 1.2 0.70 6.2 0.86 7.4 4.10 8.4 43.90

[object Object],/39 Complexes stacked can be homogeneous or mixed.

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[object Object],/39 RM β CD( Randomly methylated β -CD) HP β CD( Hydroxy propyl β -CD)* HP γ CD(Hydroxy propyl γ -CD) DM β CD( 2,4- dimethyl β -CD)** SBE β CD( Sulfobutylether β -CD)

[object Object],/39 From Frömming and Szejtli: Cyclodextrins in Pharmacy Kluwer Acad. Press, Dordrecht, 1994 .

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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39 CD formulation: Diazepam 5.0 mg HP  CD 60.0 mg Sodium chloride 6.0 mg Purified water ad 1.00 ml About 93% water.

[object Object],World-wide there are close to 30 cyclodextrin containing pharmaceutical products on the market and most of them are marketed in more than one country. Almost half of them contain the natural  CD. /39

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solubility enhancement -by pH change & complexation

solubility enhancement -by pH change & complexation

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solubility enhancement -by pH change & complexation

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