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Niosomes as Drug Carriers

Niosomes as Drug Carriers

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Niosomes as Drug Carriers

  1. 1. Niosomes as Drug Carriers<br />
  2. 2. What are Niosomes?<br /><ul><li>Niosomes are non-ionic surfactant vesicles. The success achieved with Liposomal systems stimulated the search for other vesicles forming amphiphiles. </li></li></ul><li>What are Niosomes?<br /><ul><li>Non-ionic surfactants were among the first alternative materials studied. A large number of surfactants have been found to self assemble into bilayer vehicles which can be used as drug delivery. </li></li></ul><li>Structure of Niosomes<br />
  3. 3. Advantages of Niosomes<br /><ul><li>Sustained release of active compounds
  4. 4. Protect drugs from degradation
  5. 5. Unique characteristics:
  6. 6. Biocompatible
  7. 7. biodegradable
  8. 8. non-immunogenic</li></li></ul><li>Advantages of Niosomes<br /><ul><li>Can trap both hydrophilic and lipophilic drugs
  9. 9. Have low toxicity due to non-ionic nature.
  10. 10. Can be used for ophthalmic preparations because their bilayer can efficiently penetrate cornea of the eye.</li></li></ul><li>Applications Of Niosomes<br /><ul><li>Antitumor Niosomes
  11. 11. Niosomes and other drugs
  12. 12. Niosomes as vaccine adjuvants</li></li></ul><li>AntitumourNiosomes<br /><ul><li>Niosomes encapsulation of methotrexate and doxorubicin increase drug delivery to tumour and tumoricidal activity.
  13. 13. Unlike non stealth liposomes, 800 nm doxorubicin niosomes possessing a triglycerol or 200nm doxorubicin niosomes possessing a muramic acid surface are not significantly taken up by RES. These triglycerolniosomes accumulate in the tumour. </li></li></ul><li>Anti-tumor Niosomes<br /><ul><li>This may prove advantageous for treatment of hepatic neoplasm. The encapsulation of these polymeric prodrugs within 200nm niosomes provides a depot system within the liver from which the free drug is gradually cleaved off and the liver level of drug is increased over a 24 hour period.
  14. 14. Activity of other anticancer drugs, such as Vincristine, Bleomycin are also improved with niosomes encapsulation.</li></li></ul><li>Niosome Therapies<br />The uptake of Niosomes by the liver and spleen, makes them ideal for targeting disease manifesting in these organs, i.e. Leismaniasis. <br />A number of studies have shown that Niosomal formulations of sodium stibogluconate improves parasite suppression in acting peptide drugs as intramuscular administration.<br />
  15. 15. Niosomes as Vaccine Adjuvants<br /><ul><li>Niosomal antigens are potent stimulators of the cellular and immune response.
  16. 16. The formulation of antigens as a Niosome in a water-in-oil emulsion further increases the activity of antigens.
  17. 17. Enhancement of the immunological response is due to the controlled release property of the emulsion formulation.</li>

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