This slide was presented by Dr Lily Eurwilaichitr at the ICCC13, Beijing, China on Sept 24, 2013

1. Thailand Bioresource Research Center
(TBRC): Network Integration of Quality
Management for Culture Collection
Copyright @2013 TBRC, BIOTEC, Thailand
TBRC: a National BRCTBRC: a National BRC
Bioresources Technology Research Unit,
National Center for Genetic Engineering and
Biotechnology (BIOTEC), Thailand
http://www.biotec.or.th/btu
Thailand Bioresource Research Center
(TBRC), Thailand
http://www.tbrcnetwork.org
Lily Eurwilaichitr and Supawadee Ingsriswang

2. Microbes: a key to success in bio-based economy
Chemicals
Materials
Energy/Fuels
Renewable
resources
(e.g. palm, sugar cane)
Fossil
resources
(e.g. petroleum)
Research Utilization
Preservation Distribution
TBRC
Enzyme
Microbe Thermocatalysis
Bio-process
Industrial biotechnology
Biorefinery BioFuels
Chemicals
Bioplastics
Drugs
Food/Feed
Biomass
Agriculture
Microbial
Diversity/
Community
Competitive
advantage
Copyright @2013 TBRC, BIOTEC, Thailand

3. TBRC: a National BRCTBRC: a National BRC
Bioresource Research
Center
Bioresource Research
Center
Copyright @2013 TBRC, BIOTEC, Thailand

4. Thailand Bioresource Research Center TBRC
Food and Feed
Innovation Center
NSTDA-JGSEE
Integrative
Biorefinery
Laboratory
New initiatives of BIOTEC
4
Copyright @2013 TBRC, BIOTEC, Thailand

5. Bioresources Data Network
TBRC and its networkTBRC and its network
TBRC
Copyright @2013 TBRC, BIOTEC, Thailand

6. Bioresources Data Network
TBRC: Networking the UniversitiesTBRC: Networking the Universities
TBRC
Copyright @2013 TBRC, BIOTEC, Thailand
Universities

7. TBRC Network Structure
Copyright @2013 TBRC, BIOTEC, Thailand
Regional
TBRC Hubs
TBRC
Members
(Collections
)
TBRC

8. Copyright @2013 TBRC, BIOTEC, Thailand
TBRC Member

9. Copyright @2013 TBRC, BIOTEC, Thailand
Users of TBRC
must be
guaranteed
reliable, high-
quality
biological
resources and
information.

10. =Authenticity of biological materials, databases
and bioinformatics and accuracy of labelling.
=Processing of cultures, cell lines, and genetic
constructs, including procedures and
standards for ensuring their long-term stability
and quality control.
=Accuracy of the data collected and supplied.
=Expertise and training of human resources,
particularly of a new generation of taxonomists
able to use molecular techniques and
informatics.
=Sharing of expertise among centres through
co-ordination and networking.
Copyright @2013 TBRC, BIOTEC, Thailand

11. Q1Q1 Q2Q2
Q3Q3
Quality of Microbial Cultures Quality of Data
Quality of Services
Quality
Management
System @TBRCCopyright @2013 TBRC, BIOTEC, Thailand

12. Quality Management System @TBRC
Copyright @2013 TBRC, BIOTEC, Thailand
TBRC
operation
Cultures QMS
Data QMS
Services QMS
Standard and Procedures
Deposit
Preserve
(subculture)
Depositor, Officer, Document,
Correctness, Consistency,
Missing info
Contamination,
Preserve
(storage) Distribute

13. • Science in the 21st Century is Data-Driven Science.
• Data Integration is key to Biological DB Management System.
• Data Quality is a top concern of data integration.
High quality data will lead to knowledge for research
excellence.
• High quality data
–well organized, documented, preserved and accessible
–accuracy and validity
Copyright @2013 TBRC, BIOTEC, Thailand

14. Copyright @2013 TBRC, BIOTEC, Thailand

15. Copyright @2013 TBRC, BIOTEC, Thailand
TBRC Web services
iCollect: Software for TBRC Material ProvidersiCollect: Software for TBRC Material Providers

16. Facilitate the workflow of BRC
• Sample/Specimen
Management
• Storage Management
• Quality Control
• Service Management
iCollect:iCollect:
An Enhanced Solution for Biological Resources ManagementAn Enhanced Solution for Biological Resources Management
Web services (SOAP)
TBRC
TBRC
Enable cross-platform data sharing
Data Standardization and Integration
Control the quality of data
Data Verification & Validation,
Data Traceability
Copyright @2013 TBRC, BIOTEC,
Thailand

17. Built-in workflow system for quality
control
– Tracking the status for each step in
service process
Copyright @2013 TBRC, BIOTEC,
Thailand

18. Copyright @2013 TBRC, BIOTEC,
Thailand
Database Management for BRC
Collection
Reader
Collection
Reader
Data
Structure
Data
Structure
DataData
Taxonomy
Validator
Taxonomy
Validator
Geolocator
Validator
Geolocator
Validator

19. • Taxon Data Crosschecking with
Species2000 and other DBs
• Check spelling (province, etc)
• Checking via Google Map
Sample Management
Copyright @2013 TBRC, BIOTEC,
Thailand
Database Management for BRC
Data Validation –Consistency, Integrity

20. Copyright @2013 TBRC, BIOTEC, Thailand
Microbe++: Using text mining to build TBRC
strain catalog

21. Integration to BIOTEC & Country’s Biotech industry
TBRC
• Strategic microbe
catalogues
• Enzyme producer
databases
Prototype products
+ Formulation
+ Production Design & Engineering
Microbes
Enzymes
Microbial agents
Chemicals
One-stop focal point for microbial
product development & demonstration
L I3 years
3 months
Copyright @2013 TBRC, BIOTEC, Thailand

22. Copyright @2013 TBRC, BIOTEC, Thailand
Maintaining the quality of
data and materials and
their validation will require
harmonised co- ordination
between BRCs and
bioinformatics databases so as
to provide the range of services
required by the international
community of life scientists and
the global biotechnology
industry.