1. XerumFree™ – by TNCBIO
General presentation,
Eindhoven – The Netherlands, 30 november 2011

2. Contents
• TNCBIO
o strategy
o people
o company
• XerumFree™
o principle
o positioning
• Products
o production
o results
o distribution

3. TNCBIO – strategy
• Fully defined product
o replacing FBS in mammalian (incl. stem-)cell culture
o XerumFree™ as a platform
• Target markets
o (stem-) cell research & development
o production
o toxicology
• Full portfolio
o FBS-replacements (available october 2011)
o attachement and detachment factors (Q1 2012)
o cryo preservation medium (Q1 2012)

4. TNCBIO – people
•Science
o Michel Fischbach (managing partner & CSO)
o Animal Physiology, Nutrition, Biochemistry (Ph.D.)
• Sales
o Maarten van Tiel (managing partner)
o clinical chemistry
•Operations (Marcom/Finance/Legal)
o Diederik Klaassen (managing partner)
o business administration
•Public Relations
o Eric van Heeswijck (managing partner)
o business administration

5. TNCBIO – company
•Dates
o Founded – june 2011
o Samples available – september 2011
o Introduction XerumFree™ – oktober 2011
• Places
o Eindhoven - The Netherlands (head office)
o TU/e Eindhoven, Catalyst - The Netherlands (lab)
o Milano area – Italy
o New York area - US (2012)
•Funding
o privat

6. XerumFree™ principle
Fully defined & animal component free:
• No batch-to-batch variations
o eliminates testing, storage and scientific variations
• No unnecessary/unwanted components
o very low protein level (and only recombinant)
o no growth factors, hormones etc
• No contamination risk
o no viruses, no prions, no sterilisation or stripping necessary
• no future problems
o no regulatory, legislation or ethical end user concerns

7. Positioning XerumFree™
generations in cell culture media 1950s 2011

8. Production XerumFree™
• Sterile version
o own lab: Catalyst Building - Technical University Eindhoven
• GMP & stem cell version
o outsourced to GMP facilities in The Netherlands
• Packaging
o Nalgene bottles - 100 ml, 500 ml,
o single pack, 20 pack and 100 pack
o special packages (bags, bulk or concentrate) on request
• Volume production
o per January 2012

9. Results XerumFree™
External - confirmed (till 20-11) Internal - in addition
CHO Liver Epithelial
HEK 293 Hepatocytes
SH SY5Y Vero
3T3 HaCaT
Fibroblasts HUT78
Hybridomas Per.C6
Stem cells (see brochure)
Kc167
S2

10. Distribution XerumFree™
• Direct
o via web shop (January 1st 2012) at list price + shipping
• Distribution
o all European countries, US and Japan
o per january 2012
• OEM
o one world wide contract for large production plants
o bulk packages only

11. XerumFree™ – by TNCBIO
the pure company
www.tncbio.com
www.youtube.com/xerumfree
www.twitter.com/thenakedcell
www.slideshare.net/thenakedcell
www.tncbio.com/blog