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Y1S2 Synapse NMJ Neurotransmitters

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Physiology of synapse, neuromuscular junction and neurotransmitters Prof. Vajira Weerasinghe Dept of Physiology Faculty of Medicine University of Peradeniya
What is a synapse? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Many different types
Basic structure ,[object Object],[object Object],[object Object],[object Object],[object Object]
Synaptic transmission ,[object Object],[object Object],[object Object],[object Object]
Neurotransmitters ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Neurotransmitter release ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ca 2+ Ca 2+
Neurotransmitter receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Postsynaptic activity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Neurotransmitters
Acetylcholine (Ach) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Norepinephrine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dopamine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
GABA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Glycine ,[object Object],[object Object],[object Object],[object Object]
Glutamate & Aspartate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Serotonin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NEUROPEPTIDES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NEUROPEPTIDES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NEUROPEPTIDES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
OPIOID PEPTIDES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other peptides present in the CNS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Neuromodulators ,[object Object],[object Object],[object Object],[object Object],[object Object]
Neuromuscular junction
Neuromuscular junction ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Presynaptic terminal (terminal knob, boutons, end-feet or synaptic knobs) ,[object Object],[object Object],Vesicles containing neurotransmitter (Ach)
Presynaptic terminal (terminal knob, boutons, end-feet or synaptic knobs) ,[object Object],[object Object],[object Object],[object Object]
Ca 2+ Ca 2+
Postsynaptic membrane (motor end plate) ,[object Object],[object Object],Ach Na+ ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Ach release ,[object Object],[object Object],[object Object],[object Object]
End plate potential ,[object Object],[object Object],[object Object]
Acetylcholinerase (AchE) ,[object Object],[object Object],[object Object],[object Object]
Axoplasmic transport ,[object Object],[object Object],[object Object],[object Object],[object Object]
Smooth muscles ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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