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BACK PAIN
Classification and Pathology
By
Wafer Aldulaimi/ Denmark
Introduction

80% of all individuals have experienced back
pain in thier life time by the age of 60 years.
Classification of back pain

Pain is differentiated into
nociceptive, inflammatory, neuropathic and
functional pain.
Functional pain
Functional pain
• No morphological correlate can be found in
functional pain.
• Peripheral tissue damage and neural
injuries changes in the pain pathways
abnormal responsiveness or function of the
dorsal root ganglion of the nervous system , as
follows:
• Reduction in pain threshold (allodynia)
• increased response to noxious stimuli
(hyperalgesia)
• increase in the duration of response to brief
stimulation (persistent pain) and a spread of
pain .
This phenomenon is called

neuroplasticity
Syndromes which belong to this class of pain are
•
•
•
•
•

Fibromyalgia
Irritable bowel syndrome
Non-cardiac chest pain
Tension headache
Whiplash syndrom
NB
• Genetic predisposition and biopsychosocial
factors have a significant influence on pain
perception .

• Adjuvant drugs (e.g.
antidepressants, anticonvulsants, anxiolytics)
enhance the centraleffect of analgesics and
should be included for an adequate treatment of
moderate to severe pain .
Anatomy
Causes ofpain
1.
2.
3.
4.
5.
6.
7.

Spinal degeneration
Trauma
Chronic pathological changes
Spinal deformity
Inflammatory diseases
Space occupying and destructive lesions
Referred pain
Spinal Degeneration
The Intervertebral Disc
start as small tears in the annulus fibrosus
increase in size to form radial fissures  extend
into the nucleus pulposus  loss of
proteoglycans and water content from the
nucleus  loss of the height of the disc  disc
collapses  shortening the distance between the
two vertebral bodies  vertebral sclerosis +
Osteophytes.
The cardinal symptoms of discogenic
back pain are :
1) predominant low-back pain .
2) pain aggravation in disc compression and
flexion by forward bending, sitting, coughing,
sneezing , walking.
3) non-radicular pain radiation in the anterior
thigh ( referred pain)
The facet joint

Begin with an inflammatory synovitis  gradual
thinning of the cartilage  subperiosteal
osteophytes  enlarge both the inferior and
superior facets.
The cardinal symptoms of facet joint
pain are :
1) predominant low-back pain
2) osteoarthritis pain type (morning stiffness ,
improvement during motion- early stage)
3) pain aggravation in extension and rotation
(backward bending ,standing, walking
downhill)
4) non-radicular pain radiation in the posterior
thigh (referred pain )
Treatment of the degenerative disc
and facet joint
Non-operative Treatment
The mainstay of non-operative management rests
on three pillars:
1) pain management (medication)
2) functional restoration (physical exercises)
3) cognitive-behavioral therapy (psychological
intervention)
Operative Treatment
• Non-instrumented Spinal Fusion
• Instrumented Spinal Fusion
1. Pedicle Screw Fixation
2. Translaminar Screw Fixation
3. Cage Augmented Interbody Fusion
4. Total Disc Arthroplasty
TRAUMA
Disc Herniation
Compressive or rotational forces on the spine 
tear of the annulus fibrosis  the nucleus
pulposus may migrate through the tear, causing a
protrusion of the disc .
Degenerated discs that already have some degree
of annular tearing, have less
elasticity and are less able to withstand these
forces.
• If the disc herniation protrudes posteriorly in
the midline compression of the cauda
equina or spinal cord .

• If the disc protrudes laterally  compression
on the nerve root .
symptoms
• Radiculopathic symptoms.
• These symptoms must correspond to the
respective dermatome and myotome of
the compromised nerve root to allow for a
conclusive diagnosis.
Treatment
Conservative Measures for mild radiculopathy
1) Bed rest (< 3 days)
2) Analgesics
3) Anti-inflammatory medication
4) Physiotherapy
Operative Treatment for severe radiculopathy (
Cauda equina syndrom, severe paresis ,etc.)
Standard operations  Laminotomy and
discectomy
Fractures

With or without neurological symptoms.
Operative and non-operaive treatment.
Chronic Pathological changes
The effects of acute and cumulative trauma 
progressive degenerative changes that affect
both the intervertebral disc and the posterior
facets.
Spinal Stenosis

Degenerative changes  significant stenosis of
the central canal and lateral foramina 
disrupt function within the spinal cord and
nerve roots.
A pathomorphological changes as:
1) hypertrophy of the ligamentum flavum
2) hypertrophy of the facet joints
3) osteophyte formations
4) disc herniation
5) vertebral displacements (anterior/lateral)
Symptoms are :
pain or numbness in the legs on activity and
which is relieved with rest, known as 
neurogenic claudication.
Treatment
Conservative treatment  mild symptoms
1) medication (analgetics, NSAIDs, muscle
relaxants) .
2) postural education and therapeutic exercise
with avoidance of extension .
3) epidural infiltration of corticosteroids .
Operative treatment  Decompression
with or without instrumentation.
MUSCLE TRAUMA, IMMOBILIZATION
AND ATROPHY

Pain due to degenerative changes  reduces
the patients activity  atrophy of the
paraspinal muscles.
• Muscle atrophy is visible within 3-4 weeks and
after 3 months completemuscle atrophy.
• The atrophied muscles is replaced by fibrous
collagen.
• Muscle atrophy can cause functional pain.
Normal muscle tissue
After 4 weeks of immobilisation
After 7 weeks immobilisation
After 3 months of immobilisation
SPINAL DEFORMITY

Traumatic, congenital and degenerative
changes can all result in deformity of spinal
structures.
SPONDYLOLYSIS
• The vertebral arch attaches to the vertebral body
through the pedicles. The laminae originate from
the pedicle at a comparatively weak area known
as the pars interarticularis or isthmus.

• In childhood and adolescence, this area is subject
to fatigue fracture, which may not heal properly
and can lead to a fibrous union rather than a
stable bony union.
• This can happen unilaterally or bilaterally.
• If it occurs bilaterally , it creates an area of
weakness between the anterior and posterior
components of the vertebral arch.
• If this is stable , it may not be clinically
important and can be an incidental finding
seen on X-rays and CT scan.
ISTHMIC SPONDYLOLISTHESIS
Bilateral spondylolysis , can  separation of
the anterior and posterior elements of the
vertebral arch  slippage of the superior
vertebral body on the inferior vertebral body
 degenerative changes.
As the spondylolisthesis progresses 
widening of the central spinal canal.
DEGENERATIVE SPONDYLOLISTHESIS
During the process of degeneration , there is a
period in which the two adjacent segments
are hypermobile  slippage  narrowing of
the central spinal canal
Treatment
• Conservative for mild cases: pain relief
, physiotherapy

• Operative for severe cases: spinal fusion
(instrumented and non instrumented)
SCOLIOSIS
• Deformity of the normal vertical and/or sagital
alignment of spinal segments.

• The causes : congenital , spontaneous and
degenerative.
INFLAMMATORY DISEASES
There are a number of systemic diseases that
impact on the spine and can result in changes
in bony structure, resulting in deformity.
Rheumatoid arthritis
Paget’s disease
Ankylosing spondylitis
(Bekhterev's disease)
Space-occupying and destructive
lesions
Spinal tumors

Tumors that affect the spine can be primary
benign or malignant .Primary or metastatic
tumors spreading from other organs .
SPINAL INFECTIONS

The vertebral column , the intervertebral
discs, the dural sac or the space around the
spinal cord may become infected.
The infection may be caused by bacteria or
fungal organisms.
REFERRED PAIN
TAK

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Back Pain

  • 1. BACK PAIN Classification and Pathology By Wafer Aldulaimi/ Denmark
  • 2. Introduction 80% of all individuals have experienced back pain in thier life time by the age of 60 years.
  • 3. Classification of back pain Pain is differentiated into nociceptive, inflammatory, neuropathic and functional pain.
  • 4.
  • 6. Functional pain • No morphological correlate can be found in functional pain. • Peripheral tissue damage and neural injuries changes in the pain pathways abnormal responsiveness or function of the dorsal root ganglion of the nervous system , as follows:
  • 7. • Reduction in pain threshold (allodynia) • increased response to noxious stimuli (hyperalgesia) • increase in the duration of response to brief stimulation (persistent pain) and a spread of pain .
  • 8. This phenomenon is called neuroplasticity
  • 9. Syndromes which belong to this class of pain are • • • • • Fibromyalgia Irritable bowel syndrome Non-cardiac chest pain Tension headache Whiplash syndrom
  • 10. NB • Genetic predisposition and biopsychosocial factors have a significant influence on pain perception . • Adjuvant drugs (e.g. antidepressants, anticonvulsants, anxiolytics) enhance the centraleffect of analgesics and should be included for an adequate treatment of moderate to severe pain .
  • 12.
  • 13.
  • 14. Causes ofpain 1. 2. 3. 4. 5. 6. 7. Spinal degeneration Trauma Chronic pathological changes Spinal deformity Inflammatory diseases Space occupying and destructive lesions Referred pain
  • 15. Spinal Degeneration The Intervertebral Disc start as small tears in the annulus fibrosus increase in size to form radial fissures  extend into the nucleus pulposus  loss of proteoglycans and water content from the nucleus  loss of the height of the disc  disc collapses  shortening the distance between the two vertebral bodies  vertebral sclerosis + Osteophytes.
  • 16.
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  • 19. The cardinal symptoms of discogenic back pain are : 1) predominant low-back pain . 2) pain aggravation in disc compression and flexion by forward bending, sitting, coughing, sneezing , walking. 3) non-radicular pain radiation in the anterior thigh ( referred pain)
  • 20. The facet joint Begin with an inflammatory synovitis  gradual thinning of the cartilage  subperiosteal osteophytes  enlarge both the inferior and superior facets.
  • 21.
  • 22.
  • 23. The cardinal symptoms of facet joint pain are : 1) predominant low-back pain 2) osteoarthritis pain type (morning stiffness , improvement during motion- early stage) 3) pain aggravation in extension and rotation (backward bending ,standing, walking downhill) 4) non-radicular pain radiation in the posterior thigh (referred pain )
  • 24. Treatment of the degenerative disc and facet joint Non-operative Treatment The mainstay of non-operative management rests on three pillars: 1) pain management (medication) 2) functional restoration (physical exercises) 3) cognitive-behavioral therapy (psychological intervention)
  • 26. • Instrumented Spinal Fusion 1. Pedicle Screw Fixation 2. Translaminar Screw Fixation 3. Cage Augmented Interbody Fusion 4. Total Disc Arthroplasty
  • 27.
  • 28.
  • 29. TRAUMA Disc Herniation Compressive or rotational forces on the spine  tear of the annulus fibrosis  the nucleus pulposus may migrate through the tear, causing a protrusion of the disc . Degenerated discs that already have some degree of annular tearing, have less elasticity and are less able to withstand these forces.
  • 30. • If the disc herniation protrudes posteriorly in the midline compression of the cauda equina or spinal cord . • If the disc protrudes laterally  compression on the nerve root .
  • 31.
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  • 35. symptoms • Radiculopathic symptoms. • These symptoms must correspond to the respective dermatome and myotome of the compromised nerve root to allow for a conclusive diagnosis.
  • 36. Treatment Conservative Measures for mild radiculopathy 1) Bed rest (< 3 days) 2) Analgesics 3) Anti-inflammatory medication 4) Physiotherapy
  • 37. Operative Treatment for severe radiculopathy ( Cauda equina syndrom, severe paresis ,etc.) Standard operations  Laminotomy and discectomy
  • 38.
  • 39. Fractures With or without neurological symptoms. Operative and non-operaive treatment.
  • 40. Chronic Pathological changes The effects of acute and cumulative trauma  progressive degenerative changes that affect both the intervertebral disc and the posterior facets.
  • 41. Spinal Stenosis Degenerative changes  significant stenosis of the central canal and lateral foramina  disrupt function within the spinal cord and nerve roots.
  • 42. A pathomorphological changes as: 1) hypertrophy of the ligamentum flavum 2) hypertrophy of the facet joints 3) osteophyte formations 4) disc herniation 5) vertebral displacements (anterior/lateral)
  • 43. Symptoms are : pain or numbness in the legs on activity and which is relieved with rest, known as  neurogenic claudication.
  • 44.
  • 45.
  • 46.
  • 47. Treatment Conservative treatment  mild symptoms 1) medication (analgetics, NSAIDs, muscle relaxants) . 2) postural education and therapeutic exercise with avoidance of extension . 3) epidural infiltration of corticosteroids .
  • 48. Operative treatment  Decompression with or without instrumentation.
  • 49.
  • 50. MUSCLE TRAUMA, IMMOBILIZATION AND ATROPHY Pain due to degenerative changes  reduces the patients activity  atrophy of the paraspinal muscles.
  • 51. • Muscle atrophy is visible within 3-4 weeks and after 3 months completemuscle atrophy. • The atrophied muscles is replaced by fibrous collagen. • Muscle atrophy can cause functional pain.
  • 53. After 4 weeks of immobilisation
  • 54. After 7 weeks immobilisation
  • 55. After 3 months of immobilisation
  • 56. SPINAL DEFORMITY Traumatic, congenital and degenerative changes can all result in deformity of spinal structures.
  • 57. SPONDYLOLYSIS • The vertebral arch attaches to the vertebral body through the pedicles. The laminae originate from the pedicle at a comparatively weak area known as the pars interarticularis or isthmus. • In childhood and adolescence, this area is subject to fatigue fracture, which may not heal properly and can lead to a fibrous union rather than a stable bony union.
  • 58. • This can happen unilaterally or bilaterally. • If it occurs bilaterally , it creates an area of weakness between the anterior and posterior components of the vertebral arch. • If this is stable , it may not be clinically important and can be an incidental finding seen on X-rays and CT scan.
  • 59.
  • 60.
  • 61.
  • 62. ISTHMIC SPONDYLOLISTHESIS Bilateral spondylolysis , can  separation of the anterior and posterior elements of the vertebral arch  slippage of the superior vertebral body on the inferior vertebral body  degenerative changes.
  • 63. As the spondylolisthesis progresses  widening of the central spinal canal.
  • 64.
  • 65.
  • 66.
  • 67. DEGENERATIVE SPONDYLOLISTHESIS During the process of degeneration , there is a period in which the two adjacent segments are hypermobile  slippage  narrowing of the central spinal canal
  • 68.
  • 69. Treatment • Conservative for mild cases: pain relief , physiotherapy • Operative for severe cases: spinal fusion (instrumented and non instrumented)
  • 70. SCOLIOSIS • Deformity of the normal vertical and/or sagital alignment of spinal segments. • The causes : congenital , spontaneous and degenerative.
  • 71.
  • 72.
  • 73.
  • 74. INFLAMMATORY DISEASES There are a number of systemic diseases that impact on the spine and can result in changes in bony structure, resulting in deformity.
  • 78. Space-occupying and destructive lesions Spinal tumors Tumors that affect the spine can be primary benign or malignant .Primary or metastatic tumors spreading from other organs .
  • 79.
  • 80. SPINAL INFECTIONS The vertebral column , the intervertebral discs, the dural sac or the space around the spinal cord may become infected. The infection may be caused by bacteria or fungal organisms.
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  • 85. TAK