The document discusses the role of science and operations in developing the James Webb Space Telescope mission. It describes the science goals that JWST aims to address, including detecting the first galaxies and studying star and planet formation. It outlines the key instruments onboard and discusses how STScI will manage science operations and the ground system once JWST is launched. STScI has been influencing mission development to help achieve the science objectives through activities like simulations, requirements development, and system trades.