VMware vSphere is a virtualization platform that includes the ESXi hypervisor and vCenter Server management software. The document outlines the agenda for a VMware vSphere presentation, which includes topics such as virtualization, ESXi, vCenter, virtual machine management, networking, storage, vMotion, high availability, and other advanced features. It also provides overviews of ESXi hardware requirements, new features in vSphere 5.0, and how to upgrade from a previous version to vSphere 5.0.