1. April 7, 2013
Asiatic Health News
Efficacy of esomeprazole for preventing relapses in patients with healed esophagitis
The new proton pump inhibitor Esomeprazole is effective as a maintenance therapy
in GERD patients with healed erosive esophagitis
BACKGROUND:
Esomeprazole, the S-isomer of Omeprazole, is the first proton pump inhibitor to be
developed as an optical isomer. In patients with erosive esophagitis, Esomeprazole has
produced significantly greater healing rates and improved symptom resolution.
METHODS:
In this 6-month US multicentre randomized double-blind placebo-controlled trial, 375
Helicobacter pylori-negative patients with Endoscopically healed Esophagitis received
Esomeprazole 20 mg or placebo once daily.
80 %
30 %
Esomeprazole Placebo
Healing Rate
RESULTS:
Significantly more patients remained healed with Esomeprazole 20 mg (80.00 %) than with
placebo (30.00 %). Sustained resolution of heartburn was observed in 20 mg groups; there
was a high correlation between absence of heartburn and maintenance of healing.
Ref: 1. Aliment Pharmacol Ther. 2001 Jul;15(7):927-35.
CONCLUSIONS:
Esomeprazole is effective and well-tolerated in the maintenance of healing of erosive
Esophagitis. Esomeprazole 20 mg offer significant clinical benefit to patients.
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