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Myeloproliferative Disorders Overview

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Myeloproliferative disorders include polycythemia vera, essential thrombocytosis, myelofibrosis, and chronic myeloid leukemia. Polycythemia vera is a neoplastic stem cell disorder characterized by erythrocytosis, thrombocytosis, and leukocytosis. Treatment involves phlebotomy and myelosuppressive drugs like hydroxyurea. Essential thrombocytosis is characterized by elevated platelet counts over 600,000 and enlarged, abnormal megakaryocytes. It can cause thrombosis. Myelofibrosis features bone marrow fibrosis, splenomegaly, anemia, and thrombocytopenia. Chronic myeloid leukemia is a malignant disorder caused by the Philadelphia chromosome resulting from a

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Myeloproliferative Disorders
Overview ,[object Object],[object Object],[object Object],[object Object],[object Object]
Polycythemia ,[object Object],[object Object],[object Object]
[object Object]
Classification of true polycythemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Polycythemia vera ,[object Object],[object Object],[object Object]
P vera - symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Erythromelalgia
P vera – signs: ,[object Object],[object Object],[object Object],[object Object]
P vera - Lab Findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WHO criteria ,[object Object],[object Object],[object Object],[object Object],[object Object]
WHO criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - phlebotomy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - Myelosuppression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
P vera - interferon alpha ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Essential Thrombocythemia ,[object Object],[object Object],[object Object]
ET - Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - natural history ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - Labs ,[object Object],[object Object],[object Object],[object Object],[object Object]
ET - Abnormal Megakaryocytes Arrows indicate some of the abnormal mega-karyocytes
ET - Treatment ,[object Object],[object Object],[object Object],[object Object]
ET - therapeutic agents ,[object Object],[object Object],[object Object]
ET - anagrelide ,[object Object],[object Object]
Myelofibrosis ,[object Object]
MF - Natural Hx and Sx ,[object Object],[object Object],[object Object],[object Object],[object Object]
MF - Physical Findings ,[object Object],[object Object]
MF - Lab findings ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leucoerythroblastic blood film in a patient with idiopathic myelofibrosis. Note the nucleated red blood cell and the myelocyte
Causes of leukoerythroblastic blood picture ,[object Object],[object Object],[object Object],[object Object],[object Object]
MF - Treatment ,[object Object],[object Object],[object Object],[object Object]
Chronic myeloid leukemia ,[object Object],[object Object]
Incidence ,[object Object]
Presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical course ,[object Object]
Massive splenomegaly
Pathogenesis ,[object Object],[object Object],[object Object],[object Object]
Lab ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Investigation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Advanced disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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