Myeloproliferative disorders include polycythemia vera, essential thrombocytosis, myelofibrosis, and chronic myeloid leukemia. Polycythemia vera is a neoplastic stem cell disorder characterized by erythrocytosis, thrombocytosis, and leukocytosis. Treatment involves phlebotomy and myelosuppressive drugs like hydroxyurea. Essential thrombocytosis is characterized by elevated platelet counts over 600,000 and enlarged, abnormal megakaryocytes. It can cause thrombosis. Myelofibrosis features bone marrow fibrosis, splenomegaly, anemia, and thrombocytopenia. Chronic myeloid leukemia is a malignant disorder caused by the Philadelphia chromosome resulting from a