The internet has provided access to unprecedented quantities of data. In the domain of chemistry specifically over the past decade the web has become populated with tens of millions of chemical structures and related properties of assays together with tens of thousands of spectra and syntheses. The data have, to a large extent, remained disparate and disconnected. In recent years with the wave of Web 2.0 participation any chemist can contribute to both the sharing and validation of chemistry-related data whether it be via Wikipedia, the online encyclopedia, or one of the multiple public compound databases. The presentation will offer a perspective of what is available today, our experiences of building a public compound database to link together the internet and a suggested path forward for enabling even greater integration and connectivity for chemistry data for the masses to both use and participate in developing.

1. How the Web Has Weaved a Web of Interlinked Chemistry Data Antony Williams ACS Anaheim March 29 th 2011

2. Data on the Web

4. How to Connect Chemicals…

6. www.chemspider.com

7. Search for a Chemical

11. The Structure of Vitamin K?

13. The Structure of Vitamin K1?

14. What is the Structure of Vitamin K1?

15. CAS’s Common Chemistry

16. Wikipedia

19. ChEBI – Manual Curation

22. PubChem

31. Vytorin: Ezetimibe/Simvastatin

32. Vytorin: Ezetimibe/Simvastatin

33. Vytorin: Ezetimibe/Simvastatin

34. Vytorin: Ezetimibe/Simvastatin

35. Vytorin: Ezetimibe/Simvastatin

36. Taxol: Paclitaxel 44 structures

37. Taxol: Paclitaxel Bioassay Data

39. Drug Name Generic Name ChEBI ChemSpider CAS Com. Chem ChemIDPlus DailyMed DrugBank PubChem Wikipedia Spiriva Tiotropium Bromide No Hits  No Hits    4/0  Depakote Valproate semisodium        No Structure Basen Voglibose   No Hits  No Hits  2/1  Symbicort 1) Budesonide       8/1  Symbicort 2) Formoterol WRONG  No Hits    6/1  Vytorin 1) Ezetimibe   No Hits      Vytorin 2) Simvastatin       2/1  Taxol Paclitaxel       44/1  Thalidomid Thalidomide No Hits        Zocor Simvastatin       2/1  Crestor Rosuvastatin   No Hits    2/1 

40. Entity-Extraction and Mark-up

41. Entity-Extraction and Mark-up

42. Success Depends on Dictionaries

43. Nature Chemistry

44. RSC Prospect

51. Complex Data and Information

53. Kind Contributions!

54. Crowdsourcing “Vitamin H”

55. “ Curate” Identifiers

56. “ Curate” Identifiers

59. All DBs should take comments!

66. Enabled by ORCID…

70. Enabled through InChIs

71. Mobile Support