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Molecular Genetics The Central Dogma of Biology
What is a Genetic “Factor”? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Requirements of Genetic Material ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chromosomes – The First Clue ,[object Object],[object Object],[object Object],[object Object],[object Object]
Chromosome Observations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Importance of Sex Chromosomes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
What Carries the Genetic Information? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Discovery of DNA ,[object Object],[object Object],[object Object]
The Transforming Principle ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
The Transforming Principle is DNA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Hershey-Chase Experiment  ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
The Experiment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Experiment Summary ,[object Object],[object Object],[object Object],[object Object]
Results Summary ,[object Object],[object Object],[object Object]
 
Chargaff’s Rule   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Base Pairing in DNA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Double Helix   ,[object Object],[object Object],[object Object],[object Object]
Watson and Crick shared the 1962 Nobel Prize for Physiology and Medicine with Maurice Wilkins.  Rosalind Franklin died before this date.
DNA Structure ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Messelson and Stahl ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
The Experiment ,[object Object],[object Object],[object Object],[object Object]
The expected results for each model were:
The actual results were as expected for the semiconservative model and thus Watson and Crick's suspicion was borne out.
Enzymes & Replication ,[object Object],[object Object],[object Object],[object Object]
The Enzymes of DNA Replication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Single-stranded Binding Proteins ,[object Object],[object Object],[object Object]
Beginning: Origins of Replication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Elongation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
The Replication Fork
DNA Polymerase ,[object Object],[object Object],[object Object],[object Object],[object Object]
Proofreading & Repair ,[object Object],[object Object]
DNA Strands are Anti-parallel ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Why 5’    3’? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Leading & Lagging Strands ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Building the Lagging Strand ,[object Object],[object Object],[object Object],[object Object]
Ligase ,[object Object],[object Object],[object Object],[object Object]
 
Primers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Primase ,[object Object],[object Object],[object Object],[object Object]
 
Ending the Strand ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Telomeres ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Telomerase ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Further Proofreading & Repair ,[object Object],[object Object],[object Object],[object Object]
Nucleotide Excision & Repair ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Proteins of DNA Replication
Summary View of Replication

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Molecular Genetics