Zhuang Wan has over 10 years of experience in biostatistics and clinical research. She holds a Master's degree in Epidemiology and Biostatistics and has worked as a consultant and research associate at various universities and cancer centers. Her roles have included collaborating with clinicians on study designs, statistical analysis, and manuscript preparation. She has extensive experience leading statistical analysis for clinical trials in areas such as cancer, ophthalmology, and infectious disease.

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Zhuang Wan, M.S.
Cell phone: 843-8102892
zxw44@case.edu
U.S. Citizen
Highlights
 Advanced training in Biostatistics with a master degree
 Experience in collaborating with clinicians on study data handling, report
generation, statistical analysis, and manuscript preparation
 Independent problem solver and team player
 Excellent oral and writing communication skills
 Knowledgeable for clinical trials and provide drug safety monitor report
 Certified in Microsoft certification with MCSE, MCDBA and MCP
 Statistical programming language and software: SAS, R, Stata
Education:
 Bachelor in Geology Engineering, ChangChun College of Geology,
ChangChun, China, 1984-1988
 Master in Epidemiology and Biostatistics, Case Western Reserve University,
Medical School, Cleveland, USA, 2008-2012
Consultant: 07/01/14 – current
 Statistical consulting in department of infectious disease at MUSC
ResearchAssociate, 03/2013 – 06/2014
Hollings Cancer Center, Medical University of South Carolina (MUSC)
 Collaborating with cancer researchers on study designs and statistical analysis
plans.
 Prepare grant and manuscript.
 Create drug safety monitor report (the summary of worst adverse events) from
REDCap.
 Lead analyst: CASE head & neck cancer study to provide the analysis racial
disparity in head and neck cancer patients
 Lead analyst: Characterization of Common Blood Test Abnormalities
Potentially Aiding Diagnosis of Mast Cell Activation Syndrome: A
Preliminary Analysis
 Lead analyst: MKP-1 Signaling Events are Required for Early
Osteoclastogenesis in Lineage Defined Progenitor Populations by Disrupting
RANKL-Induced NFATc1 Nuclear Translocation
 Lead analyst: Inhibition of Sphingosine Kinase 2 Down-regulates the
Expression of c-Myc and Mcl-1 and Induces Apoptosis in Multiple Myeloma
 Lead analyst: A Randomized Open Label Multi-Institution Phase II Study of

2. Zhuang Wan Page 2 of 3
the Combination of Bevacizumab (B) and Erlotinib (E) Compared to
Sorafenib (S) in the First-Line Treatment of Patients (pts) with Advanced
Hepatocellular Carcinoma (HCC)
 Lead analyst: Dysphagia phenotypes study to provide the impairment rate
differences in MBSImP components associated with diagnostic categories
ResearchAssistant II, 05/2011 –07/2012
 Retinal Disease Image Analysis Reading Center (REDIARC) in University
Hospitals in Cleveland OH
 Analyze the Quality Assessments for intra-reader reliability using variance
components such as relative absolute difference or statistical models.
 Predict the calibrations using mixed model when calibrated model eyes are not
readily available.
 Assistant coordinators to create some Standard Operating Procedures (SOPs),
for an example, monitor calibration.
 Deploy the calibration factors to the image database.
 Build the System Certification Checking for REDIARC using Microsoft
Access.
 Camera system certification working with the Duke Eye Center.
ResearchAssistant I, 03/2008 -04/2011
 Provide standardized, reproducible measurements of clinical ophthalmic
findings by performing quantitative and qualitative analysis of study images as
related to natural history, surgical, pharmacologic and device intervention,
safety and efficacy.
 Conduct image verification, image grade ability, importing images into image
databases.
 Perform system check and calibration, collect camera information, and
compute calibrations for the fundus images of model eyes.
Additional training:
 International Research: Applying Ethical Principles and
Research Guidelines in Global Settings (02/2011)
 CREC Program Certification on Refresher Course
HIPAA and Clinical Research (02/2011)
 CREC Program Certification
The CREC Program is in with NIH human subjects research
Educational requirements (02/2008)
 Microsoft certification (2001)
MCSE (Microsoft Certified Systems Engineer),
MCDBA (Microsoft Certified Database Administrator),
MCP (Microsoft Certified Professional)

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Publications
1. Teich ST, Wan Z, Faddoul FF. Relationship between broken appointments
and dental students' clinical experience level. J Dent Educ. 2012
Sep;76(9):1167-74. PMID: 22942412.
2. Lawrence B Afrin, Zhuang Wan, and Elizabeth G Hill. Characterization Of
Common Blood Test Abnormalities Potentially Aiding Diagnosis Of Mast
Cell Activation Syndrome: A Preliminary Analysis. Blood. 2013 November
15; Blood:122(21)
3. Valerio MS, Herbert BA, Griffin AC, Wan Z, Hill EG, Kirkwood KL. MKP-1
signaling events are required for early osteoclastogenesis in lineage defined
progenitor populations by disrupting RANKL-induced NFATc1 nuclear
translocation. Bone. 2014 Mar;60:16-25. PMID: 2426927
4. Venkata JK, An N, Stuart R, Costa LJ, Cai H, Coker W, Song JH, Gibbs K,
Matson T, Garrett-Mayer E, Wan Z, Ogretmen B, Smith C, Kang Y.
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and
Mcl-1 and induces apoptosis in multiple myeloma. Blood. 2014
Sep18;124(12):1915-25. PMID: 25122609
5. Zhiliang Hu, Zhenwu Luo, Zhuang Wan, Hao Wu, Wei Li, Tong Zhang, Wei
Jiang. HIV-associated memory B cell perturbations. Vaccine. 2015 May
21;33(22):2524-2529. doi: 10.1016/j.vaccine.2015.04.008. Epub 2015 Apr 14.
References are available upon request.