This document discusses a study on the incidence of macrovascular complications in newly diagnosed diabetic patients. The study aims to examine the occurrence of complications like cardiovascular disease, cerebrovascular disease, and peripheral vascular disease within 6 months of diabetes diagnosis. The methodology describes collecting data on risk factors, examinations, and investigations from diabetic patients. Preliminary results found cardiovascular disease in 40% of new diabetics, cerebrovascular complications in 10%, and peripheral vascular disease in 8%. Incidence was higher in patients with risk factors like hypertension, dyslipidemia, obesity, smoking, and family history of diabetes.

1. INCIDENCE OF MACROVASCULAR COMPLICATIONS IN NEWLY DIAGNOSED DIABETICS Dr. Awadhesh Kumar sharma,SR MEDICINE,MLB,MEDICALCOLLEGE JHANSI Department of Medicine M.L.B. Medical College, Jhansi

3. Body lacks insulin or is unable to use insulin effectively Diabetes Pancreas Cannot Produce Enough Insulin Muscle and Fat Cells Cannot Use Insulin Effectively

5. Epidemiology Diabetes is an ‘iceberg” disease. According to recent estimation the prevalence of diabetes mellitus in adult is 4% worldwide and it means that over 14.3 million persons are affected. At present the prevalence of DM is estimated to be 0.19% in people < 20 years old and 8.6% in people > 20 years. In individuals > 65 years old the prevalence of DM estimated to be 20.1%. The prevalence is similar in men and women through out most age ranges but its slightly greater in men more than 60 years.

6. It is projected that disease prevalence will be 5.4% by year 2025 with global diabetic population reaching 300 million. Of the close to 77% of global burden of disease is projected to occur in developing countries. The most recent study, National Urban Diabetes Survey carried out in six cities found age standardized prevalence rate of 12% for diabetes and 14% for IGT. At present total no diabetic patient in India is about 33 million and may increase upto 80 million by 2030.

10. Complications of Diabetes Retinopathy: 25x End-Stage Kidney Disease: 17x Heart Disease: 2-4x Foot/Leg Amputations: 5x Stroke: 2-6x

11. Macrovascular complication of diabetes Diabetes mellitus is the most prevalent, chronic non communicating disorder and risk of complication increases with function of duration of hyperglycemia. It involves various organs especially kidney, heart, blood vessels, eye, brain. Clinical manifestation of macrovascular disease is atherosclerosis.

12. Insulin resistance diabetes mellitus Hypertension Obesity Hyperinsulinemia Diabetes Dyslipidemia Small, dense LDL Inflammation Hypercoagulability Insulin Resistance Atherosclerosis

13. Our Study

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