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123.312 Retrosynthesis: lecture 5
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Gareth Rowlands
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123.312 Retrosynthesis: Lecture 3
123.312 Retrosynthesis: Lecture 3
Gareth Rowlands
123.312 Retrosynthesis: Lecture 2
123.312 Retrosynthesis: Lecture 2
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Questions about total synthesis and retrosynthesis
Tutorial 3 answers
Tutorial 3 answers
Gareth Rowlands
This is an experiment. It is NOT a presentation. It is meant to be an interactive pdf for students to work through/revise from at their own pace. For these features to operate I guess it needs to be downloaded first. It is based on 123.312 lectures on retrosynthesis or the design of chemical syntheses.
Retrosynthesis: 123.312
Retrosynthesis: 123.312
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Organomagnesium halide - Grignard reagent
Organomagnesium halide - Grignard reagent
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Introduction about Mukaiyama aldol reaction and its application
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Applications of Mukaiyama aldol reaction
Gurudutt Dubey
Organic Chemistry: Synthesis
Question paper and its solution of supplementary on line test on synthesis
Question paper and its solution of supplementary on line test on synthesis
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ZS - 0048 - Teks Viler - TEKS NA KRVAVOM TRAGU
ZS - 0048 - Teks Viler - TEKS NA KRVAVOM TRAGU
ZS - 0048 - Teks Viler - TEKS NA KRVAVOM TRAGU
Stripovizijacom
Recomendados
123.312 Retrosynthesis: Lecture 3
123.312 Retrosynthesis: Lecture 3
Gareth Rowlands
123.312 Retrosynthesis: Lecture 2
123.312 Retrosynthesis: Lecture 2
Gareth Rowlands
Questions about total synthesis and retrosynthesis
Tutorial 3 answers
Tutorial 3 answers
Gareth Rowlands
This is an experiment. It is NOT a presentation. It is meant to be an interactive pdf for students to work through/revise from at their own pace. For these features to operate I guess it needs to be downloaded first. It is based on 123.312 lectures on retrosynthesis or the design of chemical syntheses.
Retrosynthesis: 123.312
Retrosynthesis: 123.312
Gareth Rowlands
Preparation and reactions
Organomagnesium halide - Grignard reagent
Organomagnesium halide - Grignard reagent
Dr. Krishna Swamy. G
Introduction about Mukaiyama aldol reaction and its application
Applications of Mukaiyama aldol reaction
Applications of Mukaiyama aldol reaction
Gurudutt Dubey
Organic Chemistry: Synthesis
Question paper and its solution of supplementary on line test on synthesis
Question paper and its solution of supplementary on line test on synthesis
Tamralipta Mahavidyalaya
ZS - 0048 - Teks Viler - TEKS NA KRVAVOM TRAGU
ZS - 0048 - Teks Viler - TEKS NA KRVAVOM TRAGU
ZS - 0048 - Teks Viler - TEKS NA KRVAVOM TRAGU
Stripovizijacom
Mass spectrometry is one of the most important analytical tool for the structural elucidation of unknown organic molecules.
Mass spectrometry problems-1.
Mass spectrometry problems-1.
JyotsnaMeshram
Fragmentation rule MASS
Fragmentation rule MASS
Fragmentation rule MASS
Mahendra G S
Various substituted Triazole-Thiol containing different functional group have been synthesized by microwave method. The title product 1-[(3H-indol-2-ylamino) methyl]-4-phenyl-4, 5-dihydro-1H-1, 2, 4-triazole-3-thiol is synthesized by using amino benzothiazole. The final structures have been established on the basis of their chemical analysis and spectral data. All micro-wave synthesized compounds results into good yield as compared to conventional method of which fluoro substituted compound shows maximum yield.
Synthesis of substituted 1, 2, 4-triazole derivatives by Microwave irradiation
Synthesis of substituted 1, 2, 4-triazole derivatives by Microwave irradiation
IOSR Journals
This presentation is very useful for post graduate students from different universities and I covers all the basic aspects of Retrosynthesis.
Retrosyntheis Synthetic Strategeis - Zamir Shekh
Retrosyntheis Synthetic Strategeis - Zamir Shekh
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UGI reaction is a Multi-Component Reaction - powerful tool in drug discovery!
Ugi reaction multicomponent reactions for drug discovery!
Ugi reaction multicomponent reactions for drug discovery!
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Organolithium reagent hand written notes
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Retrosynthesis or The Disconnection approach has been discussed in this presentation. Useful Courseware for the Undergraduate and Postgraduate students of Pharmacy , and Chemical Sciences
Retrosynthesis or the discconection approach
Retrosynthesis or the discconection approach
Ateos Foundation of Science Education and Research, Pune, M.S., India
140 name reactions in brief. Its mechanisms and advantages and disadvantages. All structures were made by individuals without pasting from other sources.
Organic Chemistry Name Reaction with mechanisms 140
Organic Chemistry Name Reaction with mechanisms 140
TusharRanjanNath
It is an intramolecular rearrangement reaction in which the 1,2-migration of silyl group from carbon to oxygen under basic conditions.It involves the formation of a pentacoordinate siliconintermediate.Discovered by Adrian Gibbs Brook in 1958.
Brook rearrangement
Brook rearrangement
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Mannich reaction (1)
Mannich reaction (1)
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Organoborane or Organoboron compounds
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Orientation and Reactivity of Nucleophilic Substitution in Pyridine, Nucleophilic Substitution Reactions of Pyridine at C-2 position
Heterocyclic Compounds Part-IV (Pyridine) by Dr Pramod R Padole
Heterocyclic Compounds Part-IV (Pyridine) by Dr Pramod R Padole
pramod padole
INTRODUCTION TO OXIDATION , WHICH IS PROCESS OF ADDITION OF OXYGEN TO THE COMPOUND IN RPOCESS CHEMISTRY AND LIQUID PHASE OXIDATION AND OTHER OXIDISING AGENTS ARE DISCUSSED.
OXIDATION [PHARMACEUTICAL PROCESS CHEMISTRY]
OXIDATION [PHARMACEUTICAL PROCESS CHEMISTRY]
Shikha Popali
Types, preparation and reactions
Organocopper compounds - Gilman reagent
Organocopper compounds - Gilman reagent
Dr. Krishna Swamy. G
attenuated total reflectance
Attenuated total reflectance spectroscopy
Attenuated total reflectance spectroscopy
chaitanya kolli
Rearragment
Demjanov rearrangement
Demjanov rearrangement
wadhava gurumeet
Basic Concepts Of Retrosynthesis (Part1)
Basic Concepts Of Retrosynthesis (Part1)
munirnizami
pharmacognosy of class of phytoconstituent "QUINONE" which includes synonyms, biological source, chemical constituents and uses of examples like CHITRAK, HENNA, VIDANG etc. included in pharmacognosy-II of T.Y.Bpharmacy.
Quinone pharmacogosy
Quinone pharmacogosy
Sanika Medhekar
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123.312 Retrosynthesis: lecture 1
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Mass spectrometry is one of the most important analytical tool for the structural elucidation of unknown organic molecules.
Mass spectrometry problems-1.
Mass spectrometry problems-1.
JyotsnaMeshram
Fragmentation rule MASS
Fragmentation rule MASS
Fragmentation rule MASS
Mahendra G S
Various substituted Triazole-Thiol containing different functional group have been synthesized by microwave method. The title product 1-[(3H-indol-2-ylamino) methyl]-4-phenyl-4, 5-dihydro-1H-1, 2, 4-triazole-3-thiol is synthesized by using amino benzothiazole. The final structures have been established on the basis of their chemical analysis and spectral data. All micro-wave synthesized compounds results into good yield as compared to conventional method of which fluoro substituted compound shows maximum yield.
Synthesis of substituted 1, 2, 4-triazole derivatives by Microwave irradiation
Synthesis of substituted 1, 2, 4-triazole derivatives by Microwave irradiation
IOSR Journals
This presentation is very useful for post graduate students from different universities and I covers all the basic aspects of Retrosynthesis.
Retrosyntheis Synthetic Strategeis - Zamir Shekh
Retrosyntheis Synthetic Strategeis - Zamir Shekh
ZAMIR SHEKH
UGI reaction is a Multi-Component Reaction - powerful tool in drug discovery!
Ugi reaction multicomponent reactions for drug discovery!
Ugi reaction multicomponent reactions for drug discovery!
Dipakchandra Sarkar
Organolithium reagent- preparation and reactions
Organolithium reagent hand written notes
Organolithium reagent hand written notes
Dr. Krishna Swamy. G
Organic chemistry
Coupling reactions 2
Coupling reactions 2
Zaid Najah
Retrosynthesis or The Disconnection approach has been discussed in this presentation. Useful Courseware for the Undergraduate and Postgraduate students of Pharmacy , and Chemical Sciences
Retrosynthesis or the discconection approach
Retrosynthesis or the discconection approach
Ateos Foundation of Science Education and Research, Pune, M.S., India
140 name reactions in brief. Its mechanisms and advantages and disadvantages. All structures were made by individuals without pasting from other sources.
Organic Chemistry Name Reaction with mechanisms 140
Organic Chemistry Name Reaction with mechanisms 140
TusharRanjanNath
It is an intramolecular rearrangement reaction in which the 1,2-migration of silyl group from carbon to oxygen under basic conditions.It involves the formation of a pentacoordinate siliconintermediate.Discovered by Adrian Gibbs Brook in 1958.
Brook rearrangement
Brook rearrangement
AnusreeAnu11
Mannich reaction (1)
Mannich reaction (1)
Shreesha Bhat
Synthesis and important reactions of organoboranes were discussed.
Organoborane or Organoboron compounds
Organoborane or Organoboron compounds
Dr. Krishna Swamy. G
Orientation and Reactivity of Nucleophilic Substitution in Pyridine, Nucleophilic Substitution Reactions of Pyridine at C-2 position
Heterocyclic Compounds Part-IV (Pyridine) by Dr Pramod R Padole
Heterocyclic Compounds Part-IV (Pyridine) by Dr Pramod R Padole
pramod padole
INTRODUCTION TO OXIDATION , WHICH IS PROCESS OF ADDITION OF OXYGEN TO THE COMPOUND IN RPOCESS CHEMISTRY AND LIQUID PHASE OXIDATION AND OTHER OXIDISING AGENTS ARE DISCUSSED.
OXIDATION [PHARMACEUTICAL PROCESS CHEMISTRY]
OXIDATION [PHARMACEUTICAL PROCESS CHEMISTRY]
Shikha Popali
Types, preparation and reactions
Organocopper compounds - Gilman reagent
Organocopper compounds - Gilman reagent
Dr. Krishna Swamy. G
attenuated total reflectance
Attenuated total reflectance spectroscopy
Attenuated total reflectance spectroscopy
chaitanya kolli
Rearragment
Demjanov rearrangement
Demjanov rearrangement
wadhava gurumeet
Basic Concepts Of Retrosynthesis (Part1)
Basic Concepts Of Retrosynthesis (Part1)
munirnizami
pharmacognosy of class of phytoconstituent "QUINONE" which includes synonyms, biological source, chemical constituents and uses of examples like CHITRAK, HENNA, VIDANG etc. included in pharmacognosy-II of T.Y.Bpharmacy.
Quinone pharmacogosy
Quinone pharmacogosy
Sanika Medhekar
Mumbai University TYB Pharm sem V
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Mass spectrometry problems-1.
Mass spectrometry problems-1.
Fragmentation rule MASS
Fragmentation rule MASS
Synthesis of substituted 1, 2, 4-triazole derivatives by Microwave irradiation
Synthesis of substituted 1, 2, 4-triazole derivatives by Microwave irradiation
Retrosyntheis Synthetic Strategeis - Zamir Shekh
Retrosyntheis Synthetic Strategeis - Zamir Shekh
Ugi reaction multicomponent reactions for drug discovery!
Ugi reaction multicomponent reactions for drug discovery!
Organolithium reagent hand written notes
Organolithium reagent hand written notes
Coupling reactions 2
Coupling reactions 2
Retrosynthesis or the discconection approach
Retrosynthesis or the discconection approach
Organic Chemistry Name Reaction with mechanisms 140
Organic Chemistry Name Reaction with mechanisms 140
Brook rearrangement
Brook rearrangement
Mannich reaction (1)
Mannich reaction (1)
Organoborane or Organoboron compounds
Organoborane or Organoboron compounds
Heterocyclic Compounds Part-IV (Pyridine) by Dr Pramod R Padole
Heterocyclic Compounds Part-IV (Pyridine) by Dr Pramod R Padole
OXIDATION [PHARMACEUTICAL PROCESS CHEMISTRY]
OXIDATION [PHARMACEUTICAL PROCESS CHEMISTRY]
Organocopper compounds - Gilman reagent
Organocopper compounds - Gilman reagent
Attenuated total reflectance spectroscopy
Attenuated total reflectance spectroscopy
Demjanov rearrangement
Demjanov rearrangement
Basic Concepts Of Retrosynthesis (Part1)
Basic Concepts Of Retrosynthesis (Part1)
Quinone pharmacogosy
Quinone pharmacogosy
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Retrosynthesis
Destacado
123.312 Retrosynthesis: lecture 1
123.312 Retrosynthesis: lecture 1
Gareth Rowlands
Basic Concepts Of Retrosynthesis (Part1)
Basic Concepts Of Retrosynthesis (Part1)
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123.312 Retrosynthesis: Lecture 4
123.312 Retrosynthesis: Lecture 4
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A GOOOOOOOOOOD BOOOK 4 RETERO SYNTHESIS
Organic synthesis the disconnection approach by stuart warren
Organic synthesis the disconnection approach by stuart warren
Sheen Khan
Lecture 6: C-C bond formation The big one; the all important formation of C-C bonds. Reagents include organometallics and enolates. There will also be a slight detour into the wonderful world of pKa.
Lecture6: 123.312
Lecture6: 123.312
Gareth Rowlands
Told you that this was the important one. This weeks reagents include more enolates and then reactions with the C=O group including the such classics as the Wittig reaction.
Lecture7: 123.312
Lecture7: 123.312
Gareth Rowlands
Basic Concepts Of Retrosynthesis (Part 2)
Basic Concepts Of Retrosynthesis (Part 2)
munirnizami
General introduction and some basic revision material.
Lecture1: 123.312
Lecture1: 123.312
Gareth Rowlands
An introduction to alcohols, their uses and substitution reactions; conversion to go leaving groups.
Lecture2: 123.312
Lecture2: 123.312
Gareth Rowlands
Finishing oxidation by looking at the Baeyer-Villiger reaction and then turning our attention to reduction. Once again we will see the usual suspects with a who is who of hydride sources.
Lecture5: 123.312
Lecture5: 123.312
Gareth Rowlands
A brief look at alcohol protecting groups and then an introduction to carboxylic acid derivatives. Start of the reactions of carboxylic acids.
Lecture3: 123.312
Lecture3: 123.312
Gareth Rowlands
Questions and answers on substrate control and chiral auxiliaries in asymmetric synthesis.
Problems 1 answers
Problems 1 answers
Gareth Rowlands
Lecture 8: the aldol reaction and conjugate additions Just what it says in the title.
Lecture8: 123.312
Lecture8: 123.312
Gareth Rowlands
Finishing off the reactions of carboxylic acid derivatives (well the substitution reactions) and introducing oxidation and reduction. Then looking at the oxidation of alkenes (epoxidation and dihydroxylation) and alcohols (the usual suspects).
Lecture4: 123.312
Lecture4: 123.312
Gareth Rowlands
Questions about substrate control in asymmetric synthesis.
Tutorial 1 answers
Tutorial 1 answers
Gareth Rowlands
An introduction to total synthesis and retrosynthesis. A quick overview of retrosynthesis followed by one of the many syntheses of (–)-stenine. This is just an overview of the fascinating world of organic synthesis, it is not intended to teach retrosynthesis or organic synthesis. For that see some of my other lecture notes.
Lecture3 123713B
Lecture3 123713B
Gareth Rowlands
More problems covering asymmetric synthesis. This time with examples of substrate control, chiral reagents, and chiral catalysis. Also another example of a synthesis.
Problems 2 answers
Problems 2 answers
Gareth Rowlands
Chiral catalysis. This is a relatively brief look at some classic examples of chiral catalysis in organic synthesis. It gives a quick overview but does not go into any detail.
Lecture2 123713A
Lecture2 123713A
Gareth Rowlands
The second set of tutorial questions on asymmetric synthesis. This one covers chiral reagents and starts enantioselective catalysis.
Tutorial 2 answers
Tutorial 2 answers
Gareth Rowlands
Use of stoichiometric amounts of a chiral source. The usual suspects will be discussed, including borane reagents (mostly pinene derivatives) and the Brown allylation.
Lecture4: 123.702
Lecture4: 123.702
Gareth Rowlands
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123.312 Retrosynthesis: lecture 1
123.312 Retrosynthesis: lecture 1
Basic Concepts Of Retrosynthesis (Part1)
Basic Concepts Of Retrosynthesis (Part1)
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123.312 Retrosynthesis: Lecture 4
Organic synthesis the disconnection approach by stuart warren
Organic synthesis the disconnection approach by stuart warren
Lecture6: 123.312
Lecture6: 123.312
Lecture7: 123.312
Lecture7: 123.312
Basic Concepts Of Retrosynthesis (Part 2)
Basic Concepts Of Retrosynthesis (Part 2)
Lecture1: 123.312
Lecture1: 123.312
Lecture2: 123.312
Lecture2: 123.312
Lecture5: 123.312
Lecture5: 123.312
Lecture3: 123.312
Lecture3: 123.312
Problems 1 answers
Problems 1 answers
Lecture8: 123.312
Lecture8: 123.312
Lecture4: 123.312
Lecture4: 123.312
Tutorial 1 answers
Tutorial 1 answers
Lecture3 123713B
Lecture3 123713B
Problems 2 answers
Problems 2 answers
Lecture2 123713A
Lecture2 123713A
Tutorial 2 answers
Tutorial 2 answers
Lecture4: 123.702
Lecture4: 123.702
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A look at epothilone A as it includes examples of many different forms of asymmetric synthesis. Also includes a little bit about ring-closing metathesis.
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123713AB lecture10
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Synthesis of hirsutene. Here because I love the use of radicals in synthesis (and yes, this lecture includes a quick re-cap of radical chemistry).
123713AB lecture09
123713AB lecture09
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MacMillan's synthesis, highlighting the use of organocatalysis.
123713AB lecture08
123713AB lecture08
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Gives an introduction to total synthesis and why we do it (which reminds me, I must add a picture of Everest, as I think the fact that 'it is there' is the main reason for most syntheses). Then to introduce the topic with a reasonably simple synthesis, we will look at an example of the synthesis of Tamiflu.
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The big topic of the last few years, the use of small organic molecules to catalyse enantioselective transformations. This lecture will start with proline before moving on to some of MacMillan's contributions to this field and, finally, finish with hydrogen bond catalysts and Brønsted acids.
123713AB lecture06
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Gareth Rowlands
This is the biggy, the one everyone wants to achieve. Here we will be looking at metal-based chiral catalysis. We will concentrate on bisoxazoline-based Lewis acid catalysis and then look at reductions before finishing with the ubiquitous Sharpless epoxidation and dihydroxylation.
123713AB lecture05
123713AB lecture05
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Use of stoichiometric amounts of a chiral source. The usual suspects will be discussed, including borane reagents (mostly pinene derivatives) and the Brown allylation.
123713AB lecture04
123713AB lecture04
Gareth Rowlands
Self explanatory really, this lecture looks at chiral auxiliaries. We will concentrate on oxazolidinones in alkylations, aldol reaction and the Diels-Alder reaction. There will be a couple examples of other auxiliaries.
123713AB lecture03
123713AB lecture03
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More substrate control, including allylic strain and directed reactions.
123713AB lecture02
123713AB lecture02
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General introduction to the course followed by a basic introduction to asymmetric or stereoselective Synthesis. Then starting the course proper by looking at substrate control.
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123713AB lecture01
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One of the many syntheses of epothilone.
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Introduction to asymmetric synthesis and total synthesis
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Lecture1 123713A
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These slides are part of a talk to school teachers. They were designed to showcase some of the applications of organic chemistry, the range of natural and synthetic products. I'm not sure how much use it is without my commentary but, as always, it seems a waste to leave it on my hard drive. The second half gave a overview of chirality and stereoisomers as this topic often causes problems with students. This second half owes a lot to an excellent paper by Robert Gawley (J. Chem. Ed. 2005, 82, 1009) and just has prettier papers. This version of the talk includes a section I removed when presenting (due to time) on artificial sweeteners.
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123.713A/B. Description of the Jacobsen synthesis of muconin. This is an example of total synthesis, retrosynthesis and asymmetric synthesis and shows the kind of information required in the assigment for this course.
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123.202 Lecture 11 - alkynes
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123.202 lecture 10 alkenes
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123.202 lectures lecture 9 alkenes
123.202 Lecture 9 - alkenes
123.202 Lecture 9 - alkenes
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123.202 Lecture 8 - alkenes
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