The document discusses neuroendocrine tumors (NETs), including their classification, markers, imaging, and molecular targeted therapy. It provides details on the WHO 2010 classification system for NETs, which grades tumors based on mitotic count and Ki-67 index. Tables provide information on gastrointestinal NETs, common tumor markers, and the sequence of optimal imaging procedures. Figures illustrate histology of NETs, metastatic patterns, molecular targets in NET cells, and functional characteristics of neuroendocrine cells. The document examines new insights into NETs of the gut and pancreas.

1. Clasificación patológica de los
Tumores neuroendocrinos
Harold J . Bolaños
MD Patólogo
Universidad del Cauca
Facultad Ciencias de la Salud
Departamento de Patología

4. Sinaptofisina

7. Figure 4 High-resolution CT scans showing the two distinct metastatic types of
ileal neuroendocrine tumors
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120

8. Table 3 Tumor markers of common use (tissue and fluid)
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120

9. Figure 2 Histology of digestive neuroendocrine neoplasms
according to tumor grade
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120

13. Table 1 Gastrointestinal neoplasms
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120

28. Figure 1 Molecular targeted therapy for NETs.
Basu B et al. Endocr Relat Cancer 2010;17:R75-R90

29. Table 2 WHO 2010 classification and suggested grading
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120

30. Table 4 Sequence of imaging procedures for optimal visualization
of primary tumors
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120

31. Figure 1 Functional characteristics of neuroendocrine cells with
relevant antigens
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120

32. Figure 3 Current therapeutic targets in the neuroendocrine tumor cell
Rindi, G. & Wiedenmann, B. (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights
Nat. Rev. Endocrinol. doi:10.1038/nrendo.2011.120