1. GENETIC TESTING OF HUMAN EMBRYOS:
ETHICAL CHALLENGES AND POLICY CHOICES
Kathy Hudson, Ph.D., Susannah Baruch, J.D., Gail Javitt, J.D., M.P.H.
The Genetics and Public Policy Center
Berman Bioethics Institute
Johns Hopkins University*
Introduction
Today, there are some one million people for whom the journey toward
personhood began when a fertility specialist, peering through a microscope, carefully
added sperm to egg in a glass petri dish – a process known as in vitro fertilization. There
have also been dramatic advances in our scientific understanding of the human genome
during this time period, which has led to the ability to test for genetic alterations
associated with diseases and other inherited characteristics. Currently there are tests for
over 1000 genetic diseases available or under development, and the number is steadily
growing.1
The independent fields of IVF and genetic testing each present a host of issues
that are technically, legally and ethically complicated. But now, the worlds of genetic
testing and assisted reproduction have converged, most notably in preimplantation
genetic diagnosis (PGD)—technology that allows parents to choose which embryos to
implant in a woman’s womb based on genetic test results. The arrival of PGD has
engendered a host of new scientific, social, ethical and political quandaries. Many people
have begun to consider not just the implications of this new genetic diagnostic tool but
whether core ethical and practical concerns surrounding IVF are really all that settled.
* This chapter was written with the generous support of the Pew Charitable Trusts. The opinions expressed
are those of the authors.
1 <http://www.genetests.org/>.

2. Adding genetic testing to the IVF process means that medical providers and
scientists can now be deeply involved in the molecular mechanics of the most profound
and mysterious of human activities: creating life. This intercession of technology into
human reproduction evokes a range of responses. For some, it is a deeply offensive act in
which science literally subsumes the role of God. For others, it allows science to alleviate
the anguish of genetic disease and infertility. These dueling opinions reveal both PGD’s
potential benefits and its possible risks. As with much modern scientific research, there is
a basic tension between concerns about the adverse consequences of unregulated research
and fears that we may fail to develop important technologies if we apply too much
restraint. Regardless of how one feels about it, PGD is a powerful tool, for it allows
parents to identify and select the genetic characteristics of their children. As a society, we
must ask whether and under what conditions PGD should be used.
In this chapter, we provide an overview of PGD and an analysis of the ethical,
legal and social issues that surround it. We then present an array of policy options that
could be employed to govern PGD’s development and use. This essay surveys the
situation of PGD in order to encourage discussion and facilitate policymaking; it does not
endorse one course of action over another. The challenge with new biomedical
technology is for the public and policymakers to keep informed despite the rapid pace of
change. We believe that new genetic technologies that alter how we have babies, and
indeed what babies we have, are so important that the public and its representatives must
be engaged in the discussion and formulation of policies.
2

3. I. What is Preimplantation Genetic Diagnosis?
PGD is a process in which embryos developed outside of the womb are tested for
particular genetic characteristics, usually genetic abnormalities that cause serious disease,
before being transferred to a woman’s uterus.2 It is always performed within the context
of in vitro fertilization (IVF), for reasons that will be developed below.
PGD derives from recent advances in both reproductive medicine and genetics. In
1978, scientists achieved the first viable human pregnancy from an egg fertilized outside
the womb. Around this time, geneticists’ understanding of the basis of inherited disorders
increased. Genetic researchers developed a number of tests to detect specific disorders.
Eventually clinicians were able to apply these tests to a small amount of genetic material
taken from an egg or embryo. The use of these tests in a human embryo (in vitro) or fetus
(in utero) enabled prenatal detection of genetic abnormalities.
PGD is a multi-step process involving egg extraction, in vitro fertilization, cell
biopsy, genetic analysis and embryo transfer. Eggs removed from the mother (after she
has been given drugs to stimulate egg production) are fertilized in the laboratory. Once
the egg is fertilized in vitro, it develops into an embryo. Most commonly, genetic tests
are performed on one or two cells taken from an embryo two to four days after
fertilization.3 The sample may be analyzed two ways: by chromosomal analysis to assess
the number or structure of chromosomes present in the cells; or by DNA analysis to detect
specific gene mutations. Regardless of the methods, the results of preimplantation genetic
diagnosis are used to inform the selection of embryos for transfer to a woman’s uterus.
2 Munne, Wells 239.
3 Handyside, Delhanty 271. Alternatively, genetic tests can be performed on polar body cells, which are
cast off by the egg as it matures and is fertilized. Verlinsky, Kuliev (1996) 13.
3

4. PGD enables two types of reproductive decisions. First, it permits doctors and
prospective parents to select embryos for implantation that do not have a genetic
abnormality associated with a specific disease, such as cystic fibrosis. Second, it enables
doctors and parents to select embryos that possess a desired genetic trait, such as a tissue
type that matches that of an ailing sibling.
Since PGD was first made available to facilitate embryo selection, more than
1,000 babies have been born worldwide following a preimplantation genetic test.4 PGD
was initially developed to detect serious single gene disorders5 and not to alleviate
infertility. More recently, however, PGD has been used as an adjunct to standard IVF to
detect abnormalities in chromosome number, called aneuploidy, that arise during egg or
embryo development. Some IVF providers recommend PGD for patients over 35 or those
with repeated IVF failure.6 Since over 1% of all U.S. newborns are IVF babies, and since
more than half of IVF patients are of advanced reproductive age,7 aneuploidy screening
likely accounts for the biggest growth area in the use of PGD. There is no required
tracking of the number of PGD procedures performed or of the purpose for which they
are performed, however, so a definitive breakdown of how many PGD procedures are
performed to detect single gene mutations versus aneuploidy is not available.
Virtually any of the hundreds of genetic tests now commercially available (and
the many more in development) could be used in PGD. The more tests available, the
more options there are for embryonic selection. Possible (but controversial) applications
4 Kuliev, Verlinsky (2004) 229.
5 The first PGD cases were performed to determine embryo sex, in order to avoid X-linked disease.
Munne, Wells 239. Other early uses included detection of genes causing cystic fibrosis, Tay Sachs disease,
and Lesch-Nyhan syndrome. Verlinsky et al. (1992) 103-110; Delhanty 1217-1227.
6 Ferraretti et al. 694-699; Munne (2003) S70-S76.
7 Kuliev, Verlinsky (2003) 233.
4

5. of PGD include its use to select an embryo that is an immunological match for a sick
sibling;8 to select the sex of an embryo in the absence of a sex-linked disease risk;9 to test
embryos for gene mutations associated with diseases such as early-onset Alzheimer
disease10 or Huntington disease11 that do not appear until later in life; or to test for
mutations that indicate a heightened but uncertain risk of developing a particular disease
such as cancer.12
There are inherent limits to the use of PGD to avoid disease or select for certain
traits. First, not all diseases have a clearly diagnosable genetic component. Many diseases
and traits are the result of a complex interaction between multiple genetic and
environmental factors. Second, if PGD is used to detect genes that indicate a heightened
risk for a particular disease, such as hereditary breast cancer, the fact that such a gene is
detected in the embryo does not mean that a person who developed from that embryo
would definitely develop the disease. Finally, it is important to remember that PGD
cannot create new genetic characteristics that neither parent has. PGD can allow parents
to select only among the genetic combinations present in the embryos they have
produced.
II. Ethical Issues and Policy Approaches
PGD raises important concerns related to whether and when it should be used, its
safety and effectiveness, costs and access, and what it would mean to live in a society
where one’s genetics become more a matter of choice than chance. Current oversight of
PGD’s safety, accuracy and effectiveness is extremely limited, as is the practice of IVF
5
8 Verlinsky et al. (2001) 3130-3133.
9 Robertson (2003a) 468-470
10 Verlinsky et al. (2002) 1018-1021.
11 Sermon et al. 591-598.
12 Rechitsky et al. 148-155.

6. generally. Limits based on ethical, moral or societal concerns are almost nonexistent. The
question is whether additional oversight is needed and if so, what issues it should address
and how it should be structured. These are complicated dilemmas about which there has
been little discussion or opportunity to form agreement.
Since PGD requires IVF, it is mainly used today by a relatively small number of
women who are willing to undergo IVF to avoid a known serious or fatal genetic
condition or who are unable to get pregnant without IVF because of infertility problems.
For people who already turn to IVF to treat infertility, PGD may become a more common
tool to screen for genetic variants ranging from the serious to what some might consider
trivial. For the moment, one would expect very few prospective parents who do not need
IVF to get pregnant and who do not seek to avoid a serious or fatal known genetic
condition to utilize PGD. Nonetheless, as the number of genetic tests that can be
employed successfully in PGD increases and IVF techniques improve, it is possible that
more prospective parents may consider using IVF and PGD to “choose” their embryo.
Hence, with the advent of new reproductive biotechnologies – of which PGD is
exemplary – there is likely to be growing public interest in developing policies that
address ethical, technical and social concerns raised by the genetic testing of embryos.
Below, we summarize the range of concerns about PGD and outline the possible policy
alternatives that could guide the future development and use of this technology.
6

7. Is PGD “ethical”?
The ethical and moral ramifications of PGD have attracted significant attention.
Some categorically oppose PGD’s use under any circumstances,13 while others have
focused on the circumstances under which it may and may not be acceptable.14
As noted previously, PGD enables the selection of one or more embryos over
others on the basis of genetic makeup. Embryos deemed genetically undesirable will
likely be destroyed if they are not frozen indefinitely. Thus, PGD and the underlying IVF
process involve the creation and, frequently, the destruction of human embryos. PGD is
therefore objectionable to people who believe that a unique human being, deserving of
the protections of a born person, is formed at the moment a sperm fertilizes an egg. From
this perspective, no use of PGD is truly “therapeutic,” because the testing does not treat
the condition it detects. Rather, it diagnoses a “patient” with the sole purpose of telling
parents which “patient” to discard. People who hold that the sanctity of human life
extends to conception therefore tend to oppose PGD.15
There are some people who do not hold a firm position on the moral status of the
early human embryo but who nonetheless oppose PGD because they view it as unnatural
or as violating the ways of nature. Still others argue that we should be wary of PGD
(even if it is not inherently wrong or offensive) because it places society atop a slippery
slope that will lead to genetic enhancement and human control of reproduction.16
13 Catholic Health Association 16.
14 Robertson (2003b) 213-16; Adams, 489-94; Botkin 17-28.
15 It should be noted that these questions first emerged with the advent of IVF, though they have often been
subsumed by the perceived good of enabling otherwise-infertile couples to bear children. In both IVF and
PGD embryos will be discarded or frozen indefinitely if they are unused; in PGD, however, embryos are
affirmatively rejected if they are deemed “unacceptable” because of the presence of a particular mutation or
the absence of a particular desirable trait.
16 The President’s Council on Bioethics raises this concern in its book Beyond Therapy, in which the
Council addresses PGD as part of a larger project on biotechnology (see especially pages 40-57).
7

8. The range of possible oversight proposals parallels the range of ethical opinions
on PGD. For those who categorically oppose PGD, a permanent ban may be the only
satisfying approach. A federal or state ban on PGD would have the benefit of creating a
clear rule for prospective parents, health care providers and society. However, an
outright ban would impose a single moral or ethical viewpoint, raise Constitutional
concerns, and could be difficult to enact and enforce.
For those who are concerned about the societal implications of PGD for certain
uses, a temporary ban – to be revisited after society has more carefully considered the
implications of this technology – might alleviate these concerns. Other possibilities
include greater federal, state, and/or professional oversight of PGD, both to ensure its
safety and effectiveness and to limit its uses to those deemed societally acceptable.
Questions About Specific Uses of PGD
PGD is now used primarily to increase the chance of having a child free of a
specific serious disease. But there are no legal limits on the use of genetic tests in PGD,
and the technology can be applied to choose a child with certain traits, such as sex and
HLA type. Although some providers believe that certain uses of PGD are unethical and
refuse to do PGD under certain circumstances (for example, to select an embryo of a
particular sex for non-health-related reasons), others advertise these services and believe
that parents should have the freedom to decide what uses of PGD are appropriate to their
particular needs.
Some observers argue that parents always have tried to give their children every
possible advantage, from vitamin supplements to private swimming lessons. PGD, they
argue, should therefore be viewed as a technology that simply extends the boundaries of
8

9. this natural tendency. Another view suggests that PGD is appropriate when used to avoid
serious genetic disease, but is inappropriate when used to detect mild conditions or
benign traits. On this logic, the use of PGD to avoid suffering outweighs the risks
involved and concerns over the status of embryos. But the balance tips when PGD is
applied to avoid a mild or treatable condition, or used to select embryos for particular
traits deemed “desirable” but whose absence does not cause suffering.
The discussion of appropriate uses is made more complex because the lines
between a serious health problem, a mild or treatable disease and a trait unrelated to
disease are diffuse and often semi-permeable. Two related questions emerge: Where is
the line to be drawn between acceptable and unacceptable uses of PGD? And who should
draw this line? As but one example, many people in the medical community would say
that a genetic predisposition to hearing loss represents a serious medical condition. Yet
many in the Deaf community consider deafness to be a culture, not a disability.17 Should
physicians, parents, or the government be the gatekeepers of “appropriate use” of
technology? Whose values should have priority – the physician who sees deafness as a
disability, the government who (in theory) sets the parameters for use of technology, or
the parents who want to avoid, or in some case select for, a deaf child? It is clear that
PGD raises the question of who decides what a “good life” is, and how far we should go
in its pursuit.
Some people question the ethics of using PGD to screen embryos for diseases that
will not affect a person until adulthood (such as Huntington disease). They reason that
children born today with those mutations would enjoy several decades of normal health
before any symptoms begin, during which time science may find a treatment or cure. The
9
17 Middleton et al. (1998) 1175.

10. same question holds for genetic mutations associated with a heightened risk (as opposed
to a certainty) for developing a particular disease. Should embryos be tested for a genetic
mutation linked to an elevated risk (but not certainty) of developing hereditary breast
cancer? Should an embryo with that mutation be summarily discarded?
Safety, Accuracy, and Effectiveness
For people who have decided to use PGD, the questions turn from broad ethical
quandaries to more immediate issues such as safety and effectiveness. There are three
chief concerns. Is this procedure safe for the mother and the resulting child? Does it
accurately detect the genetic mutation of interest? And is it effective in producing a child
free of that disease? Exploring these matters requires a consideration of the technical
challenges and risks inherent in the genetic test itself and in the IVF procedure that it
entails.
The data, however, are far from clear. There are incomplete and conflicting data
concerning the risks IVF may present to mothers who undergo the procedure and the
children conceived via this method. This situation makes it difficult to determine the
extent to which adding PGD to the IVF process may introduce additional risks. In all
IVF processes there are risks associated with the hormones used to stimulate ovulation,
and there is the risk the procedure could result in an ectopic pregnancy (in which the fetus
develops in the fallopian tubes of the mother, and not in the uterus). Because more than
one embryo is usually transferred to the uterus simultaneously, there is a heightened risk
that the mother will carry multiple fetuses, which can make for a higher risk pregnancy
for both the mother and fetuses. In addition, as with IVF generally, there is no certainty
10

11. that a pregnancy will occur after the embryo is transferred. One known risk specific to
PGD is that the biopsy to remove one or two cells from the embryo for genetic testing
may harm or destroy the embryo.
As for the accuracy and effectiveness of genetic testing, currently there is no
government review of the analytic or clinical validity of a genetic test before it is
marketed. There have been a small number of cases in which PGD failed to detect the
genetic abnormality it was intended to reveal. The targeted condition was later detected
either during pregnancy or following the birth of the child. Because an error can be
made when testing the embryo, it is often recommended that the PGD result be confirmed
by subsequent prenatal tests, such as amniocentesis or chorionic villus sampling. Some
recent data suggest that PGD may increase the success rate of IVF if it is used to test
embryos for chromosomal aneuploidy, but opinions vary on whether and under what
circumstances this is useful.
III. Current Oversight and Policy Approaches
There is currently very little oversight of PGD. In general, decisions about PGD
are left to IVF and PGD providers, who, together with patients, determine if PGD is
appropriate in particular situations. Though most existing oversight is indirect and
enforced to varying degrees, there are several oversight entities that could potentially
play larger roles in the future.
Federal Agency Oversight
PGD sits at the intersection of two technologies with ambiguous and complex
regulatory status: assisted reproduction (IVF) and genetic testing. The federal
government does not typically directly regulate the practice of medicine, leaving such
11

12. oversight to the states. Nevertheless, there are a variety of mechanisms that governmental
agencies can use to regulate or influence the safety and availability of health care services
and medical products. Three federal agencies within the U.S. Department of Health and
Human Services oversee areas related to PGD: the Centers for Disease Control and
Prevention (CDC), the Food and Drug Administration (FDA) and the Center for
Medicare and Medicaid Services (CMS, formerly known as the Health Care Financing
Administration). Federally-funded research is also subject to federal regulations for the
protection of human subjects of research.
The CDC oversees the 1992 Fertility Clinic Success Rate and Certification Act
(FCSRA).18 This law requires that IVF clinics report pregnancy success rates annually to
the federal government. The FCSRA requires clinics to report a variety of data, and
noncompliance results in the clinic being listed on the CDC’s website (other than this
minimal chastisement, there are no penalties for failure to comply with the law).
However, the FCSRA does not require IVF clinics to report the health status of babies
born as a result of the procedure or the use of diagnostic tests such as PGD.
The FDA, under the Federal Food, Drug, and Cosmetics (FD&C) Act,19 regulates
drugs and devices, including those used in IVF treatments.20 Depending on the type of
product, the FDA may require submission of data from clinical studies (premarket
review) and agency approval before the product may be sold. FDA does not regulate
most genetic tests, although it does regulate certain components that laboratories use to
18 P.L. 102-493, 106 Stat. 3146 (1992) (codified at 42 U.S.C. §§ 263a-1 et seq.)
19 Chapter 675, 52 Stat. 1040 (1938) (as amended) (codified at 21 U.S.C. § 301 et seq.).
20 For example, medicines used to stimulate ovulation are classified as “drugs” subject to the FD&C Act
and therefore must be approved by FDA before they are marketed in the United States. Similarly, culture
media used to grow human embryos in the laboratory prior to implantation are classified as "devices"
subject to premarket approval or clearance.
12

13. make those tests.21 Thus, for genetic tests in general, and those used in PGD, there is no
uniform system to assure accuracy or validity before the tests are marketed.
FDA also regulates facilities handling human tissues intended for transplantation
in order to ensure the safety of the tissue supply. Recently, FDA has decided to extend
this limited regulatory oversight to facilities handling reproductive tissues under certain
circumstances.22 In addition, FDA regulates the safety and effectiveness of certain human
tissue-based therapies, such as tissues that are manipulated extensively or are used in a
manner different from their original function in the body.23 These “biological products”
may be subject to premarket review and approval under the Public Health Service Act24
and FD&C Act. However, FDA has not determined that reproductive tissues are
biological products when used for IVF or PGD procedures, and it has not required
premarket review or approval for these tissues. Whether FDA has the legal authority
under current statutes to categorize reproductive tissues in this way or require premarket
review, and whether FDA would choose to do so if legal authority were not an issue, is
an open question.
The Center for Medicare and Medicaid Services implements the Clinical
Laboratory Improvement Amendments of 1988 (CLIA).25 CLIA includes requirements
addressing laboratory personnel qualifications, documentation and validation of tests and
procedures, quality control standards and proficiency testing to monitor laboratory
21 Medical Devices; Classification/Reclassification; Restricted Devices; Analyte Specific Reagents, 62 Fed.
Reg. 62243 (Nov. 21, 1997) (final rule) (codified at 21 C.F.R. §§ 809.10(e), 809.30, 864.4010(a), and
864.4020).
22 Human Cells, Tissues, and Cellular and Tissue-Based Products; Establishment Registration and Listing,
66 Fed. Reg. 5447 (Jan. 19, 2001) (final rule) (codified at 21 C.F.R. § 1271.1 et seq.).
23 Food and Drug Administration (1997) 12-17.
24 Chapter 373 (1944) (codified at 42 U.S.C. § 201 et seq.). The biologics provisions of the Act are codified
at 42 U.S.C. § 262.
25 P.L. 100-578, 102 Stat. 2903 (1988)(codified at 42 U.S.C. § 263a et seq.).
13

14. performance. CMS has not taken a position regarding whether laboratories engaged in
IVF meet the statutory definition of “clinical laboratories.” CMS has similarly not taken
a position regarding whether laboratories that engage in the genetic analysis component
of PGD are subject to regulation as clinical laboratories. If CLIA were applied and
enforced with respect to genetic analysis of preimplantation embryos, laboratories
engaged in this activity would be required to demonstrate proficiency under CLIA’s
general proficiency testing requirements for high complexity laboratories. However,
CMS has not yet established specific proficiency testing requirements for molecular
genetic testing. Thus, the responsibility to ensure testing proficiency for genetic tests
rests squarely with the individual laboratory.
Finally, research carried out at institutions supported with federal funds is subject
to federal requirements for protecting human research subjects.26 These requirements
also are mandatory for research to support an application to FDA for product approval.27
As it now stands, any research on PGD techniques involving human subjects would
probably fall outside federal requirements for protecting human research subjects. First,
there is a law against providing federal funding for research in which embryos are created
or destroyed. Second, embryos are not generally thought to be “human subjects” within
the meaning of federal regulations. Third, FDA does not currently require premarket
approval for PGD.
State Regulation
No state has enacted laws that directly address PGD. Some states have passed
laws related to assisted reproductive technology (ART), of which IVF is a major
14
26 45 C.F.R. Part 46.
27 21 C.F.R. Parts 50,56.

15. component. These statutes are mainly concerned with defining parentage, ensuring that
the transfer or donation of embryos is done with informed consent, or ensuring insurance
coverage for fertility treatment. Some states prohibit the use of embryos for research
purposes and one state, Louisiana, prohibits the intentional destruction of embryos
created via IVF.28 For the most part, states have not assumed oversight responsibilities
for fertility clinics.
In terms of clinical laboratories, most states do not specifically oversee
laboratories that conduct IVF or PGD as part of their administration of the CLIA
program. However, New York is in the process of developing standards for laboratories
that will include oversight of the genetic tests associated with PGD.
Court Action and Legal Precedent
Courts have addressed a variety of cases relating to assisted reproduction but only
a few concerning PGD. In one case, the parents of a child born with cystic fibrosis (CF)
following PGD sued those involved with the embryo screening for failing to detect the
condition.29 The parents made the claim of “loss of consortium,” meaning the loss of the
companionship they would otherwise have had with a healthy, non-CF-afflicted child.
The court construed their claim as one for “wrongful birth” and rejected it, finding that
the alleged harm was too speculative. The court similarly rejected the child’s claim of
“wrongful life” (made by the parents on behalf of the child), which alleged that the
defendants’ negligent failure to detect CF denied his parents an opportunity not to give
birth to him. The court also found that the defective gene itself, not the physicians, had
caused the defect. Most courts that have considered the issue have rejected wrongful life
28 La. Rev. Stat. 9:129 (2004).
29 Doolan v. IVF America, 12 Mass.L.Rep. 482 (MA Sup.Ct.2000).
15

16. claims, such those arising from a flawed prenatal test. Part of the reason for the
reluctance to accept wrongful life as a cause of action is the concern that to do so would
give credence to the argument that there can be instances in which an impaired life is
worse than no life at all. As more people take advantage of the new PGD technology,
additional legal questions may be brought before the courts, leading to the development
of a body of case law. Standards developed through case law frequently influence
legislative action or become a de facto policy by themselves.
Self-Regulation by Professional Organizations
Medical and scientific professional organizations present another opportunity for
oversight of PGD. These groups can educate their members about advances in the field,
develop guidelines addressing appropriate conduct or practices and impose standards of
adherence that are a prerequisite for membership. For the most part, however, such
standards are voluntary: an individual can choose not to belong to the organization and
therefore avoid the obligation to follow the standards. Professional organizations also
typically do not have authority to sanction members for noncompliance. Unless the
organization is specifically authorized by the federal government to act on the
government’s behalf in administering and enforcing government standards, actions of the
professional organization do not have the force of law.30
For example, the American Society for Reproductive Medicine (ASRM) is a
professional organization whose members are health professionals engaged in
reproductive medicine. ASRM issues policy statements, guidelines and opinions
regarding a variety of medical and ethical issues that reflect the thinking of the
30 This issue becomes more acute when there is limited legislation, as is the current situation (as noted
previously).
16

17. organization’s various practice committees. In 2001 ASRM issued a practice committee
opinion on PGD stating that it “appears to be a viable alternative to post-conception
diagnosis and pregnancy termination.”31 It further states that while it is important for
patients be aware of “potential diagnostic errors and the possibility of currently unknown
long-term consequences on the fetus” from the biopsy procedure, “PGD should be
regarded as an established technique with specific and expanding applications for
standard clinical practice.” ASRM has also issued an ethics committee opinion
cautioning against the use of PGD for sex selection in the absence of a serious sex-linked
disease.32
Two other professional organizations, the PGD International Society and the
European Society for Human Reproduction and Embryology (ESHRE), are potentially in
a position to play a larger oversight role for PGD. ESHRE recently issued “best practice”
guidelines for PGD.33 These guidelines are an attempt to build consensus regarding PGD
practice, while recognizing that different countries may adopt different practices because
of country-specific requirements or circumstances. The ESHRE guidelines explicitly
acknowledge that they are not intended as rules and not enforceable, but note that, in
some countries, best practice guidelines may become “standard of care” and may be
codified in law.
Several professional organizations oversee clinical laboratories and could
potentially extend their oversight to the laboratory component of PGD. For example, the
College of American Pathologists has been empowered by the federal government to
31 American Society for Reproductive Medicine 1-4.
32 The Ethics Committee of the American Society for Reproductive Medicine.
33 ESHRE PGD Consortium, Best Practice Guidelines for Clinical PGD/PGS testing.
17

18. inspect laboratories seeking certification under the Clinical Laboratory Improvement
Amendments, and the American College of Medical Genetics develops laboratory
standards or clinical practice guidelines for genetic tests. However, neither group has
developed guidelines and standards for PGD.
IV. Possible Oversight Actions, Revisions and Considerations
With this plethora of possible regulatory bodies in mind, we turn to the question
of what entities might oversee PGD, and what objectives such entities might seek to
accomplish. We consider oversight at the federal and state level, as well as oversight
through the actions of professional organizations. In the absence of agreement, decisions
about when and whether to use PGD will continue to be made largely by providers and
patients.
Policy Options
There are a number of policy approaches that could be taken to restrict the use of
PGD to those purposes deemed acceptable. Federal or state legislatures could enact a law
clearly prohibiting PGD for uses it determines to be unacceptable (e.g. sex selection for
non-health-related uses), an approach that has been used by a number of other
countries.34 This approach would require that lawmakers list and define prohibited uses,
but it also requires some degree of moral consensus among legislators and their
constituencies.
34 For example, under French law PGD is allowed only if the relevant hereditary predisposition has
previously been demonstrated to exist in the parents or in one parent, and, only for the purpose of avoiding
a severe genetic pathology. Loi no 94-654 du 29 juillet 1994 «relative au don et à l’utilisation des éléments
et produits du corps humain, à l’assistance médicale à la procréation et au diagnostic prénatal». Similarly,
in the U.K. access to PGD “is confined to individuals having a known family history of a serious genetic
disorder.” Human Fertilisation and Embryology Authority, and Advisory Committee on Genetic Testing,
Consultation document of PGD (2000). Finally, Canada recently enacted a law prohibiting PGD for sex
selection in the absence of a sex-linked disease-causing mutation. See Bill C-6, “An Act Respecting
Human Reproduction and Related Research” (Royal Assent received March 29, 2004).
18

19. Alternatively, federal or state legislatures could pass legislation delegating to a
new or existing federal agency the authority to oversee PGD, for which there is also
precedent from other countries.35 For example, Congress could pass a law giving a new
or existing federal agency the authority to oversee PGD. The agency would be
empowered to deal with matters of safety, accuracy and effectiveness. Such an entity
could be charged with:(1) Licensing and inspecting facilities that engage in PGD; (2)
Approving new PGD tests and techniques; (3) Developing regulations concerning how
PGD should be conducted, focusing on quality assurance and control; and (4) Collecting
data on health outcomes of children born following PGD.
One statute that could be broadened to explicitly cover PGD is CLIA, which
currently provides limited reassurance to patients about the safety and accuracy of genetic
tests in general and PGD in particular. CLIA could be applied and enforced with respect
to genetic analysis of preimplantation embryos. Proficiency testing standards for this
genetic analysis could be developed. Similarly, the government could authorize FDA to
broaden its oversight to require that PGD providers demonstrate the safety and
effectiveness of the genetic testing and embryo biopsy components of PGD. Those IVF-PGD
clinics would be required to conduct controlled clinical trials and submit data from
those trials to FDA. Finally, CDC’s reporting obligations for IVF clinics could be
35 For example, in 1990 the U.K. enacted the Human Fertilisation and Embryology Act, which established
the Human Fertilisation and Embryology Authority (HFEA). This Authority has the responsibility to
license and monitor clinics that carry out in vitro fertilisation (IVF) and donor insemination, license and
monitor research centres undertaking human embryo research, regulate the storage of gametes and
embryos, produce a Code of Practice which gives guidelines to clinics about the proper conduct of licensed
activities, maintain a formal register of information about donors, treatments and children born as a result
of those treatments, provide relevant advice and information to patients, donors and clinics, review
information about human embryos and any subsequent development of such embryos, and the provision of
treatment services and activities governed by the HFE Act, and advise the Secretary of State on relevant
developments in treatments and research.
19

20. rigorously enforced and expanded to include health outcomes of children born as a result
of PGD.
At the state level, public health agencies could play a role in monitoring and
improving the safety and accuracy of PGD. It is, however, difficult to create a uniform
policy approach for state public health agencies because they take so many different
statutory and bureaucratic forms. Nonetheless, each agency could take its basic charge to
protect the public health and apply it to improving the safety and accuracy of PGD, as
New York State, for example, is doing for laboratory standards (as mentioned
previously).
Professional organizations could provide significant oversight of PGD in ways
that do not require the involvement of federal or state authorities. Non-governmental
approaches to regulate PGD could involve the development of professional guidelines
through a new or existing professional organization (such as the ASRM). While such
guidelines are traditionally voluntary, they can nevertheless exert influence on medical
practice – indeed, they are often viewed as evidence of the standard of care within a
particular specialty. Since guidelines are more useful when some enforcement
mechanism is contemplated, perhaps membership could be contingent upon adherence to
the guidelines. In addition, the organization could encourage patients and those paying
for PGD services (including employers and insurance companies) to use only the services
of organization members, creating market forces in favor of compliance. The
professional society could give this mechanism additional authority through a campaign
educating the public and payors about the benefits of using providers who are members.
Since a number of different types of professionals are involved in providing PGD
20

21. services (physicians, geneticists, embryologists, technicians), collaboration among
several existing professional organizations would be optimal. These complementary
organizations could develop a comprehensive system to certify PGD providers in clinics
and laboratories, and thereby ensure a minimum level of competency. Organizations that
could collaborate to develop such a system include the American Board of Medical
Genetics, the American Board of Obstetrics and Gynecology , the American Association
of Bioanalysts, and the American College of Medical Genetics.
A second non-governmental approach would be to employ education rather than
regulation to discourage PGD for purposes deemed unacceptable. Patient groups, which
typically are organized around particular diseases or conditions, could develop their own
recommendations for appropriate use of PGD. In addition, patient groups could educate
genetic counselors and other health care professionals by including the perspective of
those living with the genetic disease or condition. Further, prospective parents could have
the opportunity to meet with persons living with a particular condition or disability as
well as their families.
There are advantages and disadvantages to each of these approaches.
Congressional intervention provides the strongest potential for national uniformity and
adequate enforcement, but risks treading on the practice of medicine, a traditional
province of state oversight. It can also be a blunt instrument for dealing with complex
and rapidly changing technologies. Federal oversight can provide scientific expertise and
greater assurance that questions concerning safety, accuracy, and effectiveness are being
adequately addressed, but it also tends to limit the pace of scientific development, slows
access to new technologies, and increases their cost. State oversight allows for more
21

22. tailored approaches, but states may lack the resources for adequate oversight. Further,
state-by-state approaches may lead to inconsistent practices, where availability of
services is dependent on one’s geographic location. Finally, professional oversight
allows those with the most direct expertise and knowledge about the practice to craft the
approach, but such an approach may be hard to enforce within the profession. It is clear
that deciding what limits are appropriate will be difficult for any entity.
The Problem of Access to PGD Services
PGD is expensive. It requires IVF, which costs upwards of $10,000-$12,000. The
addition of PGD can add $2,500-$4,000, bringing the total cost to approximately
$12,500-$16,000. Insurers may not cover PGD at all, or may pay only for the genetic
testing, leaving prospective parents to pay for the IVF. Without coverage, PGD is
available primarily to those who can pay significant out-of-pocket costs. Families who
would face the greatest financial burden of caring for children born with conditions
detectable via PGD may be the ones least able to afford it. Many insurers do not cover
IVF for infertility treatment or offer only a limited benefit. Some fertility clinics offer
ways to make IVF more affordable, and fifteen states have enacted some type of
infertility insurance coverage law, but there are no federal laws in this area.
Further, there has been no systematic investigation of insurance coverage
practices for PGD. No federal or state law, either enacted or proposed, requires health
insurers to cover PGD. To further complicate the matter, due to a quirk in Federal law,
both Congress and state legislatures would have to act in order to require insurance
coverage of all aspects of PGD. Anecdotal evidence suggests that when families are using
PGD to avoid serious genetic disorders, insurance companies are more willing to
22

23. consider the PGD medically necessary and cover the cost. At least one insurance
company covers the genetic testing component of PGD for detection of inherited genetic
disorders but not for aneuploidy. However, that company will not cover IVF if used only
to perform PGD (i.e., if the IVF is not needed because of infertility)).36
For insurers, the question of whether to cover any medical procedure or test
primarily comes down to an analysis of the potential costs and benefits of coverage. A
cost-benefit analysis of PGD would have to take into account the cost of the underlying
IVF, the embryo biopsy and the genetic testing. It is not clear whether any health insurer
in this country has undertaken a formal cost-benefit analysis of PGD for inherited genetic
disorders. There could be pressure on insurers not to pay for PGD services given the
moral issues involved. And from a health policy standpoint, there could be an argument
made that there are many other health care needs that should be covered first.
There are several alternatives to increase access to PGD without government
mandates. Private employers could include PGD in their employee benefit plans. IVF
clinics and PGD providers and laboratories could offer financial assistance directly to
prospective parents seeking PGD. Due to the high cost associated with assisted
reproductive technologies, some IVF programs offer IVF on a “shared-risk,” “warranty,”
“refund” or “outcome” basis. These plans operate by refunding a portion of the fee paid
for one or more IVF cycles in the event that they do not result in a pregnancy or live birth
of a child. Typically, shared-risk patients pay a higher fee than other IVF patients and, in
return, receive a refund of 70 to 100 percent of this fee if treatment fails. While this
means that someone who does have a baby may pay more under the shared-risk plan than
she would have under a traditional fee-for-service plan, this option helps ensure that non-
36 Aetna, <http://www.aetna.com/cpb/data/CPBA0358.html>.
23

24. pregnant couples will have the monetary resources to pursue other options for starting a
family.
Research and Data Collection
While it is sometimes fashionable in science and policy to opine that “more
research is needed,” in the case of PGD critical data are truly needed to develop effective,
evidence-based policy. Research is warranted in two directions: the safety, accuracy, and
effectiveness of PGD itself; and the informed public’s attitudes toward this technology.
Many questions remain about the safety, accuracy and effectiveness of PGD.
These include how often embryo biopsy damages or destroys embryos, how often PGD
fails to detect a genetic mutation, and whether and for whom aneuploidy screening
improves IVF results. In addition, more research is needed on the genetic tests used in
PGD in order to improve test validity. There are incomplete and conflicting data on the
long-term health effects of IVF for women and children, and no systematic studies on the
health and developmental outcomes for children born following PGD. Thus, it is difficult
to assess the baseline risk of IVF and any possible additional risk from the biopsy
component of PGD. Longitudinal studies of women who have undergone IVF and
children born following IVF and PGD would provide valuable information about the
safety and risks of IVF and embryo biopsy.
Funding for such research could come from a variety of sources, including
industry, private foundations and the federal government. Federal funding would,
however, be limited to research not involving the creation or destruction of human
embryos unless Congress lifted the current funding ban. To obtain that information, the
Fertility Clinic Success Rate and Certification Act (administered by CDC, together with
24

25. the Society for Assisted Reproductive Technology or SART) could be expanded and
enforced, requiring IVF clinics to report when PGD is used as part of an IVF procedure.
Information required could include the purpose for which PGD was used (e.g.,
aneuploidy, cystic fibrosis), whether pregnancy occurred and the outcome of such
pregnancy. Currently, clinics that fail to report information on IVF procedures face no
penalties. Officials could consider monetary or other penalties for failure to report. In
terms of insurance coverage, further research is needed to clarify current coverage
policies for PGD, the extent to which price is a barrier to patient access to PGD and the
costs and benefits for third-party payors (insurance companies and employers) of
covering PGD.
In addition, more empirical and theoretical research is needed on the potential
societal impact of PGD. To address these questions, researchers could track changes in
resources available for the disabled and in societal perceptions over time (the same could
be applied to gender selection concerns). Longitudinal psychological studies of families
who have used the procedure for a variety of reasons would provide data on the impact of
PGD on families. And last but not least, surveys of national opinion and education about
this topic will be essential in the formulation of any policy and oversight of PGD.
V. PGD and Its Future Implications for Society
Looking to the future, some observers view PGD, or any technology that allows
parents the ability to choose the characteristics of their children, as having the potential to
fundamentally alter the way we view human reproduction and our offspring as well.
They fear that human reproduction could come to be seen as the province of technology,
and children the end result of a series of meticulous, technology-driven choices.
25

26. Some argue that widespread use of PGD eventually could change the current
framework of social equality in many areas. The most dramatic possibilities involve
babies who are born with genes selected to increase their chances of having good looks,
musical talent, athletic ability, high SAT scores or whatever a parent who can afford PGD
may desire. Meanwhile, such advantages would be unavailable to the less affluent.
Such a scenario, while not possible now, is perhaps not totally implausible.
Although PGD involves a diagnostic test and embryo selection, it is not genetic
manipulation or “engineering” of the embryo itself. Over time the factors for which an
embryo is tested could grow as science elucidates the links between individual genes and
specific traits. Embryos might be selected or discarded based on genes correlated with
intellectual, physical, or behavioral characteristics.
Two sources of concern regarding PGD relate to its impact on the disabled and on
women. First, some worry that, with the increasing number of genetic tests and ability
for embryo selection, PGD could negatively impact the way society views the disabled.
Some critics argue that some of the genetic conditions that PGD can now detect, such as
those causing hereditary deafness, are merely human differences that do not limit an
individual's ability to live a useful and satisfying life. To select against these human
differences would be to create a problematic “norm” for human flourishing. Using
technology to prevent such births, these groups argue, will lead to a society in which
aesthetic concerns, convenience or mere prejudice supplant the inherent dignity due to
every human being, regardless of how closely he or she conforms to some ideal of
normality or perfection. They worry that societal norms will evolve such that parents who
26

27. are at risk of having affected children will be pressured to use PGD, even if they find the
procedure objectionable.
Others have responded that for some time now parents have had the option of
using amniocentesis and other types of prenatal diagnostic tests to probe for the same
genetic abnormalities PGD can now detect. This information sometimes prompts parents
to terminate a pregnancy to avoid having a child with a disability, yet many parents still
choose to decline testing and to give birth to children with disabilities. Society continues
to support families who make these choices. Nevertheless, anti-discrimination laws,
public education, and social programs to aid the disabled would all help to limit negative
perceptions of the disabled, and might also reduce the use of PGD by those who are
concerned about the potential societal stigma of having a disabled child.
Specific concerns also have been raised about the societal impact of using PGD
for sex selection, based on parental preferences and not on sex-linked genetic disease.
Historically, females in many societies have been subjected to discrimination based
purely on gender, and some cultures still openly prefer male children to female. Given
this situation, some observers see using PGD for sex selection as having the potential to
devalue women. However, others argue that in many countries, including the U.S., one
sex is not currently preferred over the other. When sex selection has occurred, these
proponents claim, boys and girls have been equally selected. Providers have varied
policies as well: Some refuse to conduct tests that would allow for gender selection
unless it is related to a genetic condition; others actively advertise sex-selection services.
Additional societal concerns have been raised about the potential for PGD to alter
childhood and family dynamics, particularly when it comes to parental expectations and
27

28. sibling relationships. For example, parents could end up being more critical and
demanding of a child they view as having been carefully selected to possess certain
attributes. Also, there could be tension among siblings when one is the product of PGD
and the other is not, or when one has been selected via PGD to serve as an immunological
match for another. In all cases of PGD, counseling guidelines could and should be
developed that help prompt prospective parents to consider the breadth and implications
of such matters.
Conclusion
Preimplantation genetic diagnosis raises many scientific questions and ethical
quandaries. In this chapter we have reviewed the scientific, social, ethical and legal
issues surrounding PGD and presented a range of policy alternatives that could be
employed to address specific concerns. How then does one make policy in this complex
and controversial area? A full consideration of all the policy alternatives and the benefits
and burdens, and the range of persons or entities entrusted with making these decisions,
must ensue. Only attentive and thorough debate over these topics will ensure that policy
decisions in this arena are undertaken with a clear understanding of the potential impact
of each alternative. An on-going effort to assess public attitudes about PGD and other
reproductive genetic technologies will give stakeholders and policymakers a better feel
for the diversity of opinion that surround these issues and, we hope, will enable
individuals and society as a whole to use technology wisely and to flourish.
28

29. 29
REFERENCES
Books
Kass, Leon. Beyond Therapy: Biotechnology and the Pursuit of Happiness. Regan
Books, 2003. See also President’s Council on Bioethics, Beyond Therapy:
Biotechnology and the Pursuit of Happiness. Washington, D.C. (2003), available at
http://www.bioethics.gov/reports/beyondtherapy/index.html
Articles
Adams Karen E. “Ethical Considerations of Applications of Preimplantation Genetic
Diagnosis in the United States.” Medicine and Law. 22(3) (2003):489-94.
American Society for Reproductive Medicine. “A Practice Committee Report:
Preimplantation Genetic Diagnosis." June 2001.
Botkin, Jeffrey R. “Ethical Issues and Practical Problems in Preimplantation Genetic
Diagnosis.” Journal of Law, Medicine & Ethics. 26(1) (1998): 17-28.
Catholic Health Association of the United States, “Genetics, Science, and the Church: A
Synopsis of Catholic Church Teachings on Science and Genetics.” 2003.
<http://www.chausa.org/transform/genscience.pdf>.
Delhanty, Joy A. “Preimplantation Diagnosis.” Prenatal Diagnosis. 14(13) (1994):
1217-27.
Ferraretti, A.P., Magli, M.C., Kopcow, L., Gianaroli, L. “Prognostic Role of
Preimplantation Genetic Diagnosis for Aneuploidy in Assisted Reproductive Technology
Outcome.” Human Reproduction. 19(3) (2004):694-9
Grifo, J.A., Tang, Y.X., Munne, S., Alikani, M., Cohen, J., Rosenwaks, Z. Healthy
Deliveries from Biopsied Human Embryos. Human Reproduction. 9(5) (1994):912-6
Handyside, Alan H. and Delhanty, Joy D.A. “Preimplantation Genetic Diagnosis:
Strategies and Surprises.” Trends in Genetics. 13(7) (1997):270-75.
Handyside, A.H., Lesko, J.G., Tarin, J.J., Winston, R.M., Hughes, M.R.. “Birth of a
Normal Girl After In Vitro Fertilization and Preimplantation Diagnostic Testing for
Cystic Fibrosis.” New England Journal of Medicine. 327(13) (1992):905-9.
Kuliev Anver and Verlinsky, Yuri. “Thirteen Years' Experience of Preimplantation
Diagnosis: Report of the Fifth International Symposium on Preimplantation Genetics.”
Reproductive BioMedicine Online. 8(2) (2004): 229-35.

30. Kuliev, Anver and Verlinsky, Yuri. “The Role of Preimplantation Genetic Diagnosis in
Women of Advanced Reproductive Age.” Current Opinion in Obstetrics and
Gynecology 15(3) (2003):233-8.
Middleton, A., Hewison, J., Mueller, R.F. “Attitudes of Deaf Adults toward Genetic
Testing for Hereditary Deafness.” American Journal of Human Genetics. 63
(1998):1175-1180.
Munne, Santiago. “Preimplantation Genetic Diagnosis and Human Implantation--A
Review.” Placenta. 24 (2003):S70-6
Munne, Santiago, and Wells, Dagan. “Preimplantation Genetic Diagnosis.” Current
Opinion in Obstetrics and Gynecology 14(3) (2002): 239-44.
Rechitsky, S., Verlinsky, O., Chistokhina, A., Sharapova, T., Ozen, S., Masciangelo, C.,
Kuliev, A., Verlinsky, Y. “Preimplantation Genetic Diagnosis for Cancer
Predisposition.” Reproductive Biomedicine Online. 5(2) (2002): 148-55.
Robertson, John A. “Extending Preimplantation Genetic Diagnosis: The Ethical Debate.
Ethical Issues in New Uses of Preimplantation Genetic Diagnosis.” Human
Reproduction. 18(3) (2003a):465-71.
Robertson, John A. “Extending Preimplantation Genetic Diagnosis: Medical and Non-
Medical Uses.” Journal of Medical Ethics. 29 (2003):213-216
Sermon, K., De Rijcke, M., Lissens, W., De Vos, A., Platteau, P., Bonduelle, M.,
Devroey, P., Van Steirteghem, A., Liebaers, I. “Preimplantation Genetic Diagnosis for
Huntington's Disease with Exclusion Testing.” European Journal of Human Genetics.
10(10) (2002):591-8.
The Ethics Committee of the American Society of Reproductive Medicine. “Sex
Selection and Preimplantation Genetic Diagnosis.” Fertility and Sterility. 72(4)
(1999):595-8.
Verlinsky, Yuri and Kuliev, Anvir. “Current Status of Preimplantation Diagnosis for
Single Gene Disorders.” Reproductive Biomedicine Online. 7(2): 2003:145-50.
Verlinsky, Y., Rechitsky, S., Verlinsky, O., Masciangelo, C., Lederer, K., Kuliev, A.
“Preimplantation Diagnosis for Early-Onset Alzheimer Disease Caused by
V717L Mutation.” Journal of the American Medical Association. 287(8) (2002):1018-21
Verlinsky, Y., Rechitsky, S., Schoolcraft, W., Strom, C., Kuliev, A. “Preimplantation
Diagnosis for Fanconi Anemia Combined with HLA Matching.” Journal of the American
Medical Association. 285(4) (2001):3130-3.
30

31. Verlinsky, Yuri and Kuliev, Anver. “Preimplantation Polar Body Diagnosis.”
Biochemical and Molecular Medicine. 58(1) (1996):13-17.
Verlinsky, Y., Handyside, A., Simpson, J.L., Edwards, R., Kuliev, A., Muggleton-Harris,
A., Readhead, C., Liebaers, I., Coonen, E., Plachot, M., et al. “Current Progress in
Preimplantation Genetic Diagnosis.” Journal of Assisted Reproduction and Genetics.
10(5) (1993):353-60
Verlinsky, Y., Rechitsky, S., Evsikov, S., White, M., Cieslak, J., Lifchez, A., Valle, J.,
Moise, J., Strom, C.M. “Preconception and Preimplantation Diagnosis for Cystic
Fibrosis.” Prenatal Diagnosis. 12(2) (1992):103-10.
Legal/Regulatory Materials
Bill C-6, “An Act Respecting Human Reproduction and Related Research” (Royal
Assent received March 29, 2004).
Clinical Laboratory Improvement Amendments of 1988, P.L. 100-578, 102 Stat. 2903
(1988) (codified at 42 U.S.C. § 263a et seq.).
Department of Health and Human Services, Regulations for the Protection of Human
Subjects, 45 C.F.R. Part 46 (2004).
Doolan v. IVF America, 12 Mass.L.Rep. 482 (MA Sup.Ct.2000).
Federal Food, Drug, and Cosmetics Act, Chapter 675, 52 Stat. 1040 (1938) (as amended),
(codified at 21 U.S.C. § 301 et seq.).
Fertility Clinic Success Rate and Certification Act of 1992, P.L. 102-493, 106 Stat. 3146
(1992) (codified at 42 U.S.C. §§ 263a-1 et seq.).
Food and Drug Administration. “Proposed Approach to Regulation of Cellular and
Tissue-Based Products.” February 28, 1997. <
http://www.fda.gov/cber/gdlns/celltissue.pdf>.
Food and Drug Administration, Regulations for the Protection of Human Subjects, 21
C.F.R. Part 50 and Part 56 (2004).
Human Cells, Tissues, and Cellular and Tissue-Based Products; Establishment
Registration and Listing, 66 Fed. Reg. 5447 (Jan. 19, 2001) (final rule) (codified at 21
C.F.R. § 1271.1 et seq.).
Human Fertilisation and Embryology Act, 1990, ch. 37 (Eng.).
Human Fertilisation and Embryology Authority, and Advisory Committee on Genetic
Testing, Consultation document of PGD (2000).
31

32. La. Rev. Stat. 9:129 (2004).
Loi no 94-654 du 29 juillet 1994 «relative au don et à l’utilisation des éléments et
produits du corps humain, à l’assistance médicale à la procréation et au diagnostic
prénatal».
Medical Devices; Classification/Reclassification; Restricted Devices; Analyte Specific
Reagents, 62 Fed. Reg. 62243 (Nov. 21, 1997) (final rule) (codified at 21 C.F.R. §§
809.10(e), 809.30, 864.4010(a), and 864.4020).
Public Health Service Act, Chapter 373 (1944) (codified at 42 U.S.C. § 201 et seq.).
Miscellaneous
Aetna. “Clinical Policy Bulletin No. 0358, Prenatal Diagnosis of Genetic
Diseases.”September 19, 2003. <http://www.aetna.com/cpb/data/CPBA0358.html>.
GeneTests. 26 March 2004. < http://www.genetests.org/>.
European Society for Human Reproduction and Embryology. ESHRE PGD Consortium,
“Best Practice Guidelines for Clinical PGD/PGS testing.”
<http://www.eshre.com/ecm/main.asp?lan=46&typ=122&fld=3603>.
32