Filamentous Fungi

SOME DISEASES CAUSED BY FILAMENTOUS FUNGI ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

CHROMOBLASTOMYCOSIS A chronic localized infection of the subcutaneous tissue caused by several species of dematiaceous fungi www.freelivedoctorcom

Chromoblastomycosis Fonsecaea pedrosoi Cladosporium carrionii Phialophora verrucosa www.freelivedoctorcom

Ecological Association Chromoblastomycosis ,[object Object],[object Object],www.freelivedoctorcom

Sclerotic Bodies A fungus form resulting from host defenses www.freelivedoctorcom

SCLEROTIC BODIES www.freelivedoctorcom

Chromoblastomycosis Melanin may be a virulence factor www.freelivedoctorcom

Geographic distribution World-wide (usually warmer climates) www.freelivedoctorcom

CLINICAL SPECIMENS ,[object Object],[object Object],www.freelivedoctorcom

TREATMENT ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

No Serological Tests Available www.freelivedoctorcom

Mycetoma ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

Mycetoma agents ,[object Object],[object Object],[object Object],www.freelivedoctorcom

GEOGRAPHIC DISTRIBUTION WARM CLIMATES (SE United States, South America, Africa) www.freelivedoctorcom

ECOLOGICAL ASSOCIATION SOIL www.freelivedoctorcom

Clinical Specimens Mycetoma ,[object Object],[object Object],www.freelivedoctorcom

IDENTIFICATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

De DEMATIACEOUS HYPHAE www.freelivedoctorcom

Serological Test Pseudalescheria Immunodiffusion www.freelivedoctorcom

Therapy Terbinefine Itraconazole Posaconazole www.freelivedoctorcom

Mucormycosis An acute infection characterized by inflammation and vascular invasion and thrombosis. www.freelivedoctorcom

Portal of entry ,[object Object],[object Object],[object Object],www.freelivedoctorcom

Mucormycosis *Rhizopus species Mucor species Absidia species. www.freelivedoctorcom

GEOGRAPHIC DISTRIBUTION WORLDWIDE www.freelivedoctorcom

ECOLOGICAL NICHE ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

UNCONTROLLED DIABETIC Rapidly fatal www.freelivedoctorcom

MUCORMYCOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

CHARACTERISITICS OF MUCOR INFECTION ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

WIDE, NON-SEPTATE, RIBBON-LIKE www.freelivedoctorcom

TREATMENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

SEROLOGIC TEST ,[object Object],www.freelivedoctorcom

ASPERGILLOSIS A variety of diseases: pulmonary, external ears, eyes, meninges, sinuses or blood stream www.freelivedoctorcom

CLINICAL TYPES OF PULMONARY DISEASE ,[object Object],[object Object],[object Object],www.freelivedoctorcom

Difficult to diagnose ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

COMMON PATHOGENIC SPECIES ,[object Object],[object Object],[object Object],www.freelivedoctorcom

GEOGRAPHIC DISTRIBUTION WORLD-WIDE www.freelivedoctorcom

ECOLOGICAL ASSOCIATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

Culture ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

HISTOPATHOLOGY ,[object Object],[object Object],www.freelivedoctorcom

DICHOTOMOUS BRANCHING www.freelivedoctorcom

Aspergilloma Cavity wall www.freelivedoctorcom

SEROLOGIC TESTS ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

DRUG OF CHOICE VORICONAZOLE AMPHOTERICIN B www.freelivedoctorcom

DIMORPHIC FUNGI (Endemic Mycoses) ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

BLASTOMYCOSIS Blastomyces dermatitidis www.freelivedoctorcom

BLASTOMYCOSIS A CHRONIC SUPPURATIVE AND GRANULOMATOUS DISEASE OF ANY TISSUE WITH A PREDILECTION FOR LUNGS, SKIN, PROSTATE AND BONE. www.freelivedoctorcom

PORTAL OF ENTRY ,[object Object],[object Object],[object Object],www.freelivedoctorcom

CLINICAL FORMS ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

Pulmonary Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

CLINICAL SPECIMENS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctorcom

ECOLOGICAL ASSOCIATION ORGANIC DEBRIS (SOIL, ROTTED WOOD, DECAYED VEGETATION) www.freelivedoctorcom

Virulence Factor BAD1 www.freelivedoctorcom

Identification ,[object Object],[object Object],[object Object],www.freelivedoctorcom

Wet Mount www.freelivedoctorcom

SEROLOGIC TEST ,[object Object],[object Object],[object Object],www.freelivedoctorcom

DRUGS OF CHOICE ,[object Object],[object Object],[object Object],www.freelivedoctorcom

Filamentous Fungi

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