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Hippocrates circa 400BC




“Let food be your medicine
and medicine be your food"
You Are What You Eat
• bloatedness
• diarrhea
• regurgitation
• rashes/flushing
• bloatedness
• diarrhea
• regurgitation
• rashes/flushing
Food = Nutrition

• How your body looks, feels,
  functions depends largely on
  what you put in it.

• The body needs a bare
  minimum of the right food to
  function.

• 1000 - 1800kcal per day
Lucretius circa 75BC




“What is food to one man may
 be fierce poison to another”
Food Allergy
• Immediate onset

 IgE-mediated, skin test positive, often self-diagnosed
• Delayed onset

 IgG-mediated, skin test negative, rarely self-diagnosed

 

 also called:
               Food Intolerance - UK

 
    
     
                Food Sensitivity - US
IgE Response to Food
• Generally rapid onset after ingestion

• Histamine production is rapid

• Classic ‘Allergic’ response
IgG Response to Food
• Food proteins are recognised as “foreign”

• Food specific IgG production and formation of antigen/antibody
  complexes

• Complexes are deposited in tissues and activate complement

• Complement and macrophages stimulate Inflammation

• Delayed reaction and may last for days
Common Food Intolerances

   
   
    
       Cows Milk 
   
     

   
   Cheese        
 
     
    Nuts
 

   
   
    
     
    
     
    

   
   
    
     
    
     
      
   
    Gluten 
 
     
    
     
        Wheat 
 


   
    
     
   
    
     
    

   
     Egg 

   
    
     
     Soya

   
    
     
       Yeast
Food Intolerance Test (FIT)

• Detect the presence of IgG antibodies to specific
  foods which may be implicated in food
  intolerance in symptomatic patients

  
• Provide a means to identify the foods most 

  likely to cause a problem, provided the
  symptoms 

  are food related
Food Intolerance Test (FIT)

• ELISA: Enzyme-Linked ImmunoSorbent Assay
  

• a few drops of blood
Food Intolerance Test (FIT)


• More than 200 food
  antigens tested
• antibody count >30
• ranked according to
  reactivity
• interpretation by
  physician and/or
  nutritionist
How does it affect us?

• First tissue of
  contact

• Persistent
  inflammation

• Malabsorption
Conditions related to Food IgG
•   Bloating
                  •   Abdominal pain
•   Migraines
                 •   Allergic rhinitis
•   Insomnia
                  •   Palpitations
•   Weight problems/Obesity
   •   Persistent cough
•   Anxiety
                   •   Pre-menstrual
•   Skin problems
                 problems
                               
•   Itchy skin (eczema)
•   Irritable bowl syndrome
•   Sinusitis
On endoscopy...

• Flattening of the
  absorptive surface of
  the intestines (villi)

 


• Normal villi
Malabsorption
•   Autoimmune diseases
•   Headaches
•   Fatigue
•   Depression
•   Arthritis and joint pain/stiffness and swelling
•   Chronic Respiratory symptoms (wheezing or bronchitis)
•   Abdominal Pain
•   Bowel Problems (colitis, diarrhoea, constipation)
Malabsorption
DISEASE



GENETICS    ENVIRONMENT
Thank you.

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Let food be your medicine and medicine be your food

  • 1. Hippocrates circa 400BC “Let food be your medicine and medicine be your food"
  • 2. You Are What You Eat
  • 3. • bloatedness • diarrhea • regurgitation • rashes/flushing
  • 4. • bloatedness • diarrhea • regurgitation • rashes/flushing
  • 5. Food = Nutrition • How your body looks, feels, functions depends largely on what you put in it. • The body needs a bare minimum of the right food to function. • 1000 - 1800kcal per day
  • 6. Lucretius circa 75BC “What is food to one man may be fierce poison to another”
  • 7. Food Allergy • Immediate onset IgE-mediated, skin test positive, often self-diagnosed • Delayed onset IgG-mediated, skin test negative, rarely self-diagnosed also called: Food Intolerance - UK Food Sensitivity - US
  • 8. IgE Response to Food • Generally rapid onset after ingestion • Histamine production is rapid • Classic ‘Allergic’ response
  • 9. IgG Response to Food • Food proteins are recognised as “foreign” • Food specific IgG production and formation of antigen/antibody complexes • Complexes are deposited in tissues and activate complement • Complement and macrophages stimulate Inflammation • Delayed reaction and may last for days
  • 10. Common Food Intolerances Cows Milk Cheese Nuts Gluten Wheat Egg Soya Yeast
  • 11. Food Intolerance Test (FIT) • Detect the presence of IgG antibodies to specific foods which may be implicated in food intolerance in symptomatic patients
 • Provide a means to identify the foods most 
 likely to cause a problem, provided the symptoms 
 are food related
  • 12. Food Intolerance Test (FIT) • ELISA: Enzyme-Linked ImmunoSorbent Assay • a few drops of blood
  • 13. Food Intolerance Test (FIT) • More than 200 food antigens tested • antibody count >30 • ranked according to reactivity • interpretation by physician and/or nutritionist
  • 14. How does it affect us? • First tissue of contact • Persistent inflammation • Malabsorption
  • 15. Conditions related to Food IgG • Bloating • Abdominal pain • Migraines • Allergic rhinitis • Insomnia • Palpitations • Weight problems/Obesity • Persistent cough • Anxiety • Pre-menstrual • Skin problems problems • Itchy skin (eczema) • Irritable bowl syndrome • Sinusitis
  • 16. On endoscopy... • Flattening of the absorptive surface of the intestines (villi) • Normal villi
  • 17. Malabsorption • Autoimmune diseases • Headaches • Fatigue • Depression • Arthritis and joint pain/stiffness and swelling • Chronic Respiratory symptoms (wheezing or bronchitis) • Abdominal Pain • Bowel Problems (colitis, diarrhoea, constipation)
  • 19. DISEASE GENETICS ENVIRONMENT