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Community Physician’s Role in Foodborne Illness Investigations Chicago Medical Society Chicago Department of Public Health Preparedness and Emerging Infections Training Program 2007
Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Foodborne Illness – United States ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Burden of Disease Pyramid Person exposed to pathogen Person becomes ill Person seeks medical care Specimen obtained Lab test(s) done Test confirms case Case Reported
Burden of Disease Pyramid – Foodborne Illnesses Person exposed to foodborne pathogen Person becomes ill Person seeks medical care Specimen obtained Lab test(s) done Test confirms case Case Reported Estimated 76 million  annually  in U.S.
Serious Consequences of Foodborne Illnesses ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Foodborne Disease Outbreaks: Public Health Priorities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Clinician’s Role ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Clinician’s Role ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Recognizing Suspicious Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Recognizing Suspicious Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Usual Incubation Periods for Selected Foodborne Pathogens Hepatitis A Yersinia E. coli O157:H7 Campylobacter Shigella  spp. Cyclospora cayetanensis Clostridium botulinum  toxin Enterotoxigenic  E. coli Norovirus Clostridium perfringens  toxin Vibrio parahemolyticus Bacillus cereus  toxin Staph aureus  toxin Salmonella  spp. Invasive disease Listeria GI disease 24h / 1day Hours Days 2  6  10  14  18  22 2  4  6  8  10  12  14 16 18  20  22  24  26  28  30 32  34  36  38  40  42 44 46
Recognizing Suspicious Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Duration of Illness of Common Foodborne Pathogens Bacterial pre-formed toxins ( Bacillus ,  C. perfringens ,  Staph ) 24 – 48 hrs Viruses Norovirus Rotavirus and others 12 hrs – 5 days 2 – 9 days Bacteria Campylobacter E. coli Salmonella  /  Shigella 2 – 10 days 5 – 10 days 4 – 7 days Parasites Crypto ,  Giardia ,  Cyclospora, Entamoeba Weeks to months (may remit and relapse)
Recognizing Suspicious Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Diagnosis of Foodborne Illness by Clinical Presentation Prominent Clinical Presentation Additional Signs or Symptoms Potential Food-Related Agent Vomiting Acute onset (within minutes to hours) ,[object Object],[object Object],Fever and/or diarrhea ,[object Object],[object Object],[object Object]
Diagnosis by clinical presentation, continued Prominent Clinical Presentation Additional Signs or Symptoms Potential Food-Related Agent Diarrhea Acute, watery, non-bloody (noninflammatory) ,[object Object],[object Object],Prolonged, non-bloody ,[object Object],[object Object],Bloody (inflammatory) Fever also more likely to be present with inflammatory process ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis by clinical presentation, continued Prominent Clinical Presentation Signs or Symptoms Potential Food-Related Agent Neurological Descending paralysis, blurred vision, constipation ,[object Object],Numbness and tingling of lips and mouth, weakness, vomiting and diarrhea ,[object Object],[object Object],Flushing, rash, hives, burning sensation of skin and mouth, dizziness ,[object Object]
Diagnosis by clinical presentation, continued Prominent Clinical Presentation Additional Signs or Symptoms Potential Food-Related Agent ,[object Object],[object Object],[object Object],[object Object],[object Object],Nausea, diarrhea ,[object Object],Diarrhea, dark urine, jaundice ,[object Object],Abdominal pain, constipation may be an early feature, diarrhea later, minimal vomiting ,[object Object],[object Object]
Recognizing Suspicious Symptoms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
**Disclaimer** ,[object Object],Chicago Department of Public Health
Some Food-Pathogen Associations Chicago Department of Public Health Unpasteurized Milk and Cheese Listeria monocytogenes Brucella  spp.  Fresh Produce Berries, Melon, Juice, Sprouts, Lettuce,  Spinach, Tomatoes Cyclospora, E. coli,  Salmonella Ground Beef E. coli  (especially O157:H7)
Chicago Department of Public Health Pork Trichinella spiralis, Yersinia  spp. Chicken Campylobacter, Salmonella Fried Rice Bacillus cereus Tuna Marlin Scombroid (histamine) Mahi Mahi Oysters Vibrio parahaemolyticus Eggs Salmonella  spp.
Chicago Department of Public Health Deli Meats Listeria monocytogenes Hot Dogs Home-canned fruits and vegetables  Botulinum toxin  Ice Cream  Salmonella  spp.
Patient’s Hypothesis ,[object Object],[object Object],Chicago Department of Public Health
Clinician’s Role ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Foodborne Disease Outbreak ,[object Object],[object Object],Chicago Department of Public Health
Could This Be an Outbreak? ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Could This Be an Outbreak? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
[object Object],Chicago Department of Public Health
Reported Foodborne Outbreaks ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Chicago Foodborne Outbreaks: Hospitalizations, Illnesses, & Evaluations 1997-2006 (N=116 outbreaks)
Chicago Foodborne Outbreaks: Etiologic Agents 1997-2006 (N=116) (60%) (17%) (15%) S. aureus ,  A. cantonensis ,  B. cereus ,  Ciguatoxin,  E. coli  O157, raphides
Chicago Foodborne Outbreaks: Detection Methods  1997-2006 (N=116) *FSE = Food Service Establishment, CD = Communicable Disease
Could This Be Intentional? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Clinician’s Role ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
[object Object],Foodborne Surveillance Chicago Department of Public Health Hospital Doctor’s office Citizens Private Laboratory Public Health Laboratory Local Health  Department Media CDC
Reportable Foodborne Illnesses in Illinois ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
What Happens When I Call the Health Department?  (It’s not at all like the TV shows…) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Prompt Case Report Revealed an Outbreak January 2007 ,[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
The Foodborne Disease Outbreak Investigation Team ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
http://www.elpasocitycountyhealth.com/environment/FoodInspection/FoodInspection.asp Sanitarians at work…
“ No, I’m not trying to sell you anything, sir.  I’m investigating an outbreak and all I ask is two or three hours of your time to answer a few thousand questions.” Epidemiologists at work…
Notify Public Health ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Clinician’s Role ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
When to Consider Testing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Collection of Stool Specimen ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Reasons for Specimen Rejection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
What does ordering a “routine” stool culture get? ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Bacterial Special Requests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Norovirus Diagnostic Methods ,[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
PulseNet Pulsed-Field Gel Electrophoresis (PFGE) ,[object Object],[object Object],[object Object],[object Object],Lanes 2, 3, 4, and 6, 7, 8 are  S. berta Salmonella berta  outbreak
Barriers to Testing in Foodborne Disease Outbreaks ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Facilitating Specimen Collection ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Clinician’s Role ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Physicians as Food-Safety Educators: A Practices and Perceptions Survey   Wong S, et al.  Clin Infect Dis  2004:38 (Suppl 3) pp. S212-S218. ,[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Risk Awareness vs. Risk Perception ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Advice for Patients for the Prevention of Foodborne Illness ,[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Additional Precautions for Patients at Higher Risk ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health Pregnant women / Elderly / Immunocompromised
Additional Precautions for Patients at Higher Risk ,[object Object],[object Object],Chicago Department of Public Health Infants
Eating Out? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Making Food Safer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
When Seeing Patients With  Acute Diarrhea ,[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Food Safety Web Sites ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chicago Department of Public Health
Diagnosis and management of foodborne illnesses: A primer for physicians and other health care professionals  (2 nd  Ed. 2004) ,[object Object],[object Object],[object Object],Chicago Department of Public Health

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Foodborne Illnesses Wong 2007 July

  • 1. Community Physician’s Role in Foodborne Illness Investigations Chicago Medical Society Chicago Department of Public Health Preparedness and Emerging Infections Training Program 2007
  • 2.
  • 3.
  • 4. Burden of Disease Pyramid Person exposed to pathogen Person becomes ill Person seeks medical care Specimen obtained Lab test(s) done Test confirms case Case Reported
  • 5. Burden of Disease Pyramid – Foodborne Illnesses Person exposed to foodborne pathogen Person becomes ill Person seeks medical care Specimen obtained Lab test(s) done Test confirms case Case Reported Estimated 76 million annually in U.S.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12. Usual Incubation Periods for Selected Foodborne Pathogens Hepatitis A Yersinia E. coli O157:H7 Campylobacter Shigella spp. Cyclospora cayetanensis Clostridium botulinum toxin Enterotoxigenic E. coli Norovirus Clostridium perfringens toxin Vibrio parahemolyticus Bacillus cereus toxin Staph aureus toxin Salmonella spp. Invasive disease Listeria GI disease 24h / 1day Hours Days 2 6 10 14 18 22 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46
  • 13.
  • 14. Duration of Illness of Common Foodborne Pathogens Bacterial pre-formed toxins ( Bacillus , C. perfringens , Staph ) 24 – 48 hrs Viruses Norovirus Rotavirus and others 12 hrs – 5 days 2 – 9 days Bacteria Campylobacter E. coli Salmonella / Shigella 2 – 10 days 5 – 10 days 4 – 7 days Parasites Crypto , Giardia , Cyclospora, Entamoeba Weeks to months (may remit and relapse)
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22. Some Food-Pathogen Associations Chicago Department of Public Health Unpasteurized Milk and Cheese Listeria monocytogenes Brucella spp. Fresh Produce Berries, Melon, Juice, Sprouts, Lettuce, Spinach, Tomatoes Cyclospora, E. coli, Salmonella Ground Beef E. coli (especially O157:H7)
  • 23. Chicago Department of Public Health Pork Trichinella spiralis, Yersinia spp. Chicken Campylobacter, Salmonella Fried Rice Bacillus cereus Tuna Marlin Scombroid (histamine) Mahi Mahi Oysters Vibrio parahaemolyticus Eggs Salmonella spp.
  • 24. Chicago Department of Public Health Deli Meats Listeria monocytogenes Hot Dogs Home-canned fruits and vegetables Botulinum toxin Ice Cream Salmonella spp.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.
  • 32. Chicago Foodborne Outbreaks: Hospitalizations, Illnesses, & Evaluations 1997-2006 (N=116 outbreaks)
  • 33. Chicago Foodborne Outbreaks: Etiologic Agents 1997-2006 (N=116) (60%) (17%) (15%) S. aureus , A. cantonensis , B. cereus , Ciguatoxin, E. coli O157, raphides
  • 34. Chicago Foodborne Outbreaks: Detection Methods 1997-2006 (N=116) *FSE = Food Service Establishment, CD = Communicable Disease
  • 35.
  • 36.
  • 37.
  • 38.
  • 39.
  • 40.
  • 41.
  • 43. “ No, I’m not trying to sell you anything, sir. I’m investigating an outbreak and all I ask is two or three hours of your time to answer a few thousand questions.” Epidemiologists at work…
  • 44.
  • 45.
  • 46.
  • 47.
  • 48.
  • 49.
  • 50.
  • 51.
  • 52.
  • 53.
  • 54.
  • 55.
  • 56.
  • 57.
  • 58.
  • 59.
  • 60.
  • 61.
  • 62.
  • 63.
  • 64.
  • 65.

Notas del editor

  1. Specimen i Hektoen Enteric Agar (HE) is a selective and differential medium designed to isolate and differentiate members of the species Salmonella and Shigella from other Enterobacteriaceae .  Bile salts and the dyes bromthymol blue and acid fuchsin inhibit the growth of most Gram positive organisms.  Lactose, sucrose, and salicin provide fermentable carbohydrates to encourage the growth and differentiation of enterics. Sodium thiosulfate provides a source of sulfur. Ferric ammonium citrate provides a source of iron to allow production of hydrogen sulfide from sodium thiosulfate, which provides a source of sulfur. Ferric ammonium citrate also allows the visualization of hydrogen sulfide production by reacting with hydrogen sulfide gas to form a black precipitate.  Enterics that ferment one or more of the carbohydrates will produce yellow to salmon-colored colonies. Non-fermenters will produce blue-green colonies. Organisms that reduce sulfur to hydrogen sulfide will produce black colonies or blue-green colonies with a black center. 
  2. In 2/3 of outbreaks with no identified etiology, no stool specimens are submitted for testing