Y2 s1 nmj blockers

Neuromuscular junction blockers Prof. Vajira Weerasinghe Dept of Physiology

NMJ blocking ,[object Object],[object Object]

Earliest known muscle relaxant - Curare ,[object Object],[object Object],[object Object],[object Object],[object Object]

Neuromuscular blocking agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Neuromuscular blocking agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Neuromuscular blocking agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Na + Acetylcholine Depolarization Na + - - - - + + + + - - - - + + + + + + + + + + + + - - - - - - - -

Na + Acetylcholine Tubocurarine Na + + + + + - - - - - - - - + + + + Competitive neuromuscular blocking drugs

Repolarized + + + + - - - - + + + + - - - - - - - - + + + + - - - - + + + + Depolarizing Neuromuscular blocking drugs PHASE II Membrane repolarizes but the receptor is desensitized to effect of acetylcholine

Na + Depolarized Na + - - - - + + + + + + + + - - - - - - - - + + + + + + + + - - - - - - - - Depolarizing Neuromuscular blocking drugs PHASE I Membrane depolarizes resulting in an initial discharge which produces transient fasciculations followed by flaccid paralysis

Y2 s1 nmj blockers

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Y2 s1 nmj blockers