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By
M.A.Wadood Aref
   By defnition, a fistula is an extra-
    anatomic, epithelialized tract between
    two hollow organs or between a hollow
    organ and the body surface.
   In case of urethrorectal fistulas, the tract
    occur between the urethra and the
    rectum.
 urethrorectal fistulas may be
 congenital    (associated    with
 imperforate anus & extremely rare)
 or acquired (iatrogenic or non-
 iatrogenic ).
 Acquired urethrorectal fistulas are
  typically associated with iatrogenic
  injury during pelvic surgical procedures
  and uncommonly          associated with
  pelvic radiotherapy.
 Prtedisposing     factors    for    post-
  prostatectomy urethrorectal fistulas are:
  radiation, previous rectal surgery, or
  TURP.
Iatrogenic causes of URFs include:
1. Radical Prostatectectomy (RP)
 Incidence of Rectal injury during RP is
  less than 1 - 2%,
 However, it is considered the most
  common cause due to increased number
  of radical prostatectomies done yearly.
2.   Local treatments for prostatic cancer:
     including Radiotherapy, Brachytherapy
     (0.4%), Cryotherapy (0.5 to 2%) or HIFU.
3.   Open prostatectomy or TURP or overly
     aggressive TUR of bladder neck
     contracture.
4.   Anorectal surgery: abdomino-perineal resect.
5.   Urethral instrumentation is also a rare cause
     of urethrorecal fistula
Non-iatrogenic causes of URFs include:
   Trauma: penetrating trauma.
   Malignancy: prostatic or rectal malignancy.
   Infection such as tuberculosis, Ruptured
    prostatic abscess.
   Inflammatory diseases: such as Crohn's
    disease (0.3%).


              ©
Patient with URF can be presented by:
   Fecaluria.
   Hematuria.
   Recurrent UTI refractory to treatment .
   Peritonitis and sepsis.
   Fever, Nausea and vomiting.
   Digital rectal examination (DRE): during
    rectal examination fistula track can be felt
    along the anterior rectal wall.
   Cystoscopy and sigmoidoscopy can be used
    for visualization of the fistula track & biopsy
    for detection of malignancy.
   Upper tract imaging can be used to exclude a
    related ureteral injury.
   Diagnosis of rectourethral fistula can be
    confirmed with RUG or VCUG.
   Pre-op assessment of continence and
    sphincteric function is important in
    rectourethral    fistula   after   radical
    prostatectomy because most rectourethral
    fistulas lie at or near the vesicourethral
    anastomosis and membranous urethra.
   So, stress urinary incontinence can occur
    after repair.

             ©
 Conservative treatment can cure some
  cases of post- prostatectomy URFs (open or
  laparoscopic).
 Conservative treatment include catheter
  drainage, NPO, IV Total parentral nutrition,
  anal dilatation and Antibiotics
 Fecal diversion may be needed in
  urethrorectal fistulas after brachytherapy
  or cryosurgry.
 repair of such fistulas is quiet difficult
  because it is usually large with
  induration, fibrosis and ischemia.
   Surgery is the main line of treatment in
    most of cases of urethrorectal fistulas.
   It can be performed as single stage or
    staged repair.
   Some authors have advocated fecal
    diversion and staged repair of all URFs.
Staged repair is done with fecal diversion
performed before repair of the rectourethral
fistula.
Staged repair is indicated in:
 large fistulas,
 post-radiation therapy,
 uncontrolled local or systemic infection,
 Immunocompromised,
 inadequate bowel preparation at initial oper.
Single stage repair
   Indicated in surgically induced Small fistula
    with no infection, abscess.
   Advantage of a successful one-stage
    approach is limiting the potential morbidity
    and cost of multiple procedures with the
    staged repair.

              ©
   Tranarectal approach
 Without division of anal sphincter (Transanal)

 With division of anal sphincter (York-Mason)

   Transperineal approach
   Transabdominal approach

             ©
   Transrectal approaches for URF rapair (York-
    Mason approach or transanal approach) are
    performed in the prone jackknife position.
   The transanal approach to rectourethral
    fistula repair does not involve division of the
    anal sphincter. In contrast to York-Mason
    approach.
   Techniques include rectal advancement flap
    or Latzko method.
   The main limitation of this approach is the
    limited exposure and it is best suited for small
    distal fistulae.
              ©
 Exposure of the
  fistula is provided by
  dilation of the anus
  and fixed retraction.
 Through the anal
  canal, an ellipse of
  rectal mucosa is
  removed.
   A full-thickness U-
    shaped flap of
    rectal    wall    is
    elevated above the
    fistula.
   The full-thickness flap of rectal wall is
    brought down over the fistula and sutured in
    two layers to the rectal wall.
   The technique is similar to the Latzko
    method for transvaginal VVF repair .
   Exposure of the fistula is provided by dilation
    of the anus and fixed retraction.
   The fistula track and surrounding rectal
    mucosa are denuded in all four quadrants.
   The fistula is then closed in three layers.
   The major disadvantages to this approach
    are the relatively poor exposure.
              ©
   York-Mason procedure is a transrectal,
    transsphincteric approach that has been
    shown to be effective with low morbidity.
   Staged York-Mason approach is the
    classically described repair.
   Single-stage York-Mason approach can be
    used in patients with small, non-irradiated
    fistulas with vigorous bowel preparation and
    broad-spectrum antibiotics.
              ©
 performed in a prone
  jackknife position with
  the buttocks taped
  laterally.
 Incision is performed
  from the sacrococcygeal
  juncture to the anus.
   incision is deepened
    through the posterior
    anus and dorsal rectal
    wall and deepened
    down to the level of the
    coccyx through the
    external anal sphincter
 The fistula track is excised,
  and the anterior rectal wall is
  mobilized circumferentially
  around the fistula margins.
 The urethra is closed.
 Anterior rectal wall is closed.
 Rectal     mucosa       is   re-
  approximated
 This provides 3-layer closure.
 reapproximating the post.
  rectal wall & anal sphincter.
 Results of York-Mason procedure are excellent.
 Based upon literature reports, the York-Mason
  approach has become the favored repair for URFs not
  amenable to a transanal approach.
 Renschler and Middleton in 2003 reported a
  successful repair in 22 of 24 patients.
 No serious complications were reported, and no
  patient developed anal incontinence or stenosis.
 Similar excellent results have been noted by other
  authors ( Prasad et al, 1983 ; Bukowski et al, 1995 ;
  Fengler and Abcarian, 1997) .
   A perineal approach to rectourethral fistula
    has been described in selected cases with
    good results.
   Advocated by:
     Bukowski et al, 1995.
     Nyam and Pemberton, 1999.
     Youssef et al, 1999.
     Zmora et al, 2003.
   Advantages of perineal approach include:
    being a familiar approach for many urologists
    and local accessability to a variety of
    potential interpositional flaps.
   Perineal approach with interpositional flap
    provided Excellent results.
   Interposition grafts include:
   Gracilis muscle: Ryan et al, 1979 ; Rius et al,
    2000 ; Zmora et al, 2003.
   Pedicled dartos muscle: Venable, 1989 ;
    Youssef et al, 1999 ; Yamazaki et al, 2001.
   Penile skin: Morgan, 1975.
   levator muscle: Goodwin et al, 1958.
   Bladder: Kokotas and Kontogeorgos, 1983.
 patient in the extended
  lithotomy position.
 a 20 F 30-ml filled
  balloon catheter is
  inserted.
 Use retractors to bring
  fistula into the wound,
  and insert a finger into
  the rectum as a guide.
 Divide the fistula and
  excise all surrounding
  scar tissue.
   assistant draw up on
    the catheter.
   blunt      and  sharp
    dissection between
    the      rectum   and
    prostate well above
    the fistula to reach
    normal tissue.
   Closure of the rectal
    fistula.
              ©
   Graft      can     be
    interposed between
    urethra & rectum esp.
    in teneous repair.
   urethral defect is
    closed in two layers
    with 4-0 absorbable
    suture.
   Transabdominal      approach      has    been
    described for URF rapair with limited success.
   Advocated by:
    Bukowski et al, 1995 ;
    Nyam and Pemberton, 1999 ;
    Shin et al, 2000.
   The principal advantage to this technique is
    the availability of greater omentum for an
    interpositional flap.
Potential disadvantages include:
 morbidity and prolonged postoperative
  convalescence associated with a laparotomy
  incision
 the poor exposure of the operative field
 limited maneuverability in the deep pelvis
 risk of urinary and fecal incontinence.
   Continue antibiotic administration and a low-
    residue diet postoperatively.
   Shorten the drain in 3 days and remove it the
    next day.
   Remove the catheter or cystostomy no
    sooner than the 8th day.
   Rectourethral fistulas are uncommon
    complication, it occur mostly after surgery,
    radiotherapy or minimally invasive
    treatments for prostatic cancer.
   Rare causes include surgery for BPH,
   rectourethral fistulas are usually suspected
    clinically and diagnosis can be confirmed with
    voiding cystourethrography or retrograde
    urethrogram.
              ©
   Treatment of rectourethral fistula most
    commonly involves surgical repair; however,
    select patients may respond to conservative
    therapy.
   York-Mason approach have good results and
    minimal morbidity in cases not amenable to
    transanal approach.
   Transperineal approach with interpositional
    graft is familiar with good results.
              ©
Types, Causes, Diagnosis and Surgical Repair of Urethrorectal Fistulas

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Types, Causes, Diagnosis and Surgical Repair of Urethrorectal Fistulas

  • 2. By defnition, a fistula is an extra- anatomic, epithelialized tract between two hollow organs or between a hollow organ and the body surface.  In case of urethrorectal fistulas, the tract occur between the urethra and the rectum.
  • 3.  urethrorectal fistulas may be congenital (associated with imperforate anus & extremely rare) or acquired (iatrogenic or non- iatrogenic ).
  • 4.  Acquired urethrorectal fistulas are typically associated with iatrogenic injury during pelvic surgical procedures and uncommonly associated with pelvic radiotherapy.  Prtedisposing factors for post- prostatectomy urethrorectal fistulas are: radiation, previous rectal surgery, or TURP.
  • 5. Iatrogenic causes of URFs include: 1. Radical Prostatectectomy (RP)  Incidence of Rectal injury during RP is less than 1 - 2%,  However, it is considered the most common cause due to increased number of radical prostatectomies done yearly.
  • 6. 2. Local treatments for prostatic cancer: including Radiotherapy, Brachytherapy (0.4%), Cryotherapy (0.5 to 2%) or HIFU. 3. Open prostatectomy or TURP or overly aggressive TUR of bladder neck contracture. 4. Anorectal surgery: abdomino-perineal resect. 5. Urethral instrumentation is also a rare cause of urethrorecal fistula
  • 7. Non-iatrogenic causes of URFs include:  Trauma: penetrating trauma.  Malignancy: prostatic or rectal malignancy.  Infection such as tuberculosis, Ruptured prostatic abscess.  Inflammatory diseases: such as Crohn's disease (0.3%). ©
  • 8. Patient with URF can be presented by:  Fecaluria.  Hematuria.  Recurrent UTI refractory to treatment .  Peritonitis and sepsis.  Fever, Nausea and vomiting.
  • 9. Digital rectal examination (DRE): during rectal examination fistula track can be felt along the anterior rectal wall.  Cystoscopy and sigmoidoscopy can be used for visualization of the fistula track & biopsy for detection of malignancy.  Upper tract imaging can be used to exclude a related ureteral injury.
  • 10. Diagnosis of rectourethral fistula can be confirmed with RUG or VCUG.
  • 11. Pre-op assessment of continence and sphincteric function is important in rectourethral fistula after radical prostatectomy because most rectourethral fistulas lie at or near the vesicourethral anastomosis and membranous urethra.  So, stress urinary incontinence can occur after repair. ©
  • 12.  Conservative treatment can cure some cases of post- prostatectomy URFs (open or laparoscopic).  Conservative treatment include catheter drainage, NPO, IV Total parentral nutrition, anal dilatation and Antibiotics
  • 13.  Fecal diversion may be needed in urethrorectal fistulas after brachytherapy or cryosurgry.  repair of such fistulas is quiet difficult because it is usually large with induration, fibrosis and ischemia.
  • 14. Surgery is the main line of treatment in most of cases of urethrorectal fistulas.  It can be performed as single stage or staged repair.  Some authors have advocated fecal diversion and staged repair of all URFs.
  • 15. Staged repair is done with fecal diversion performed before repair of the rectourethral fistula. Staged repair is indicated in:  large fistulas,  post-radiation therapy,  uncontrolled local or systemic infection,  Immunocompromised,  inadequate bowel preparation at initial oper.
  • 16. Single stage repair  Indicated in surgically induced Small fistula with no infection, abscess.  Advantage of a successful one-stage approach is limiting the potential morbidity and cost of multiple procedures with the staged repair. ©
  • 17. Tranarectal approach  Without division of anal sphincter (Transanal)  With division of anal sphincter (York-Mason)  Transperineal approach  Transabdominal approach ©
  • 18. Transrectal approaches for URF rapair (York- Mason approach or transanal approach) are performed in the prone jackknife position.
  • 19. The transanal approach to rectourethral fistula repair does not involve division of the anal sphincter. In contrast to York-Mason approach.  Techniques include rectal advancement flap or Latzko method.  The main limitation of this approach is the limited exposure and it is best suited for small distal fistulae. ©
  • 20.  Exposure of the fistula is provided by dilation of the anus and fixed retraction.  Through the anal canal, an ellipse of rectal mucosa is removed.
  • 21. A full-thickness U- shaped flap of rectal wall is elevated above the fistula.
  • 22. The full-thickness flap of rectal wall is brought down over the fistula and sutured in two layers to the rectal wall.
  • 23. The technique is similar to the Latzko method for transvaginal VVF repair .  Exposure of the fistula is provided by dilation of the anus and fixed retraction.  The fistula track and surrounding rectal mucosa are denuded in all four quadrants.  The fistula is then closed in three layers.  The major disadvantages to this approach are the relatively poor exposure. ©
  • 24. York-Mason procedure is a transrectal, transsphincteric approach that has been shown to be effective with low morbidity.  Staged York-Mason approach is the classically described repair.  Single-stage York-Mason approach can be used in patients with small, non-irradiated fistulas with vigorous bowel preparation and broad-spectrum antibiotics. ©
  • 25.  performed in a prone jackknife position with the buttocks taped laterally.  Incision is performed from the sacrococcygeal juncture to the anus.
  • 26. incision is deepened through the posterior anus and dorsal rectal wall and deepened down to the level of the coccyx through the external anal sphincter
  • 27.  The fistula track is excised, and the anterior rectal wall is mobilized circumferentially around the fistula margins.  The urethra is closed.  Anterior rectal wall is closed.  Rectal mucosa is re- approximated  This provides 3-layer closure.  reapproximating the post. rectal wall & anal sphincter.
  • 28.  Results of York-Mason procedure are excellent.  Based upon literature reports, the York-Mason approach has become the favored repair for URFs not amenable to a transanal approach.  Renschler and Middleton in 2003 reported a successful repair in 22 of 24 patients.  No serious complications were reported, and no patient developed anal incontinence or stenosis.  Similar excellent results have been noted by other authors ( Prasad et al, 1983 ; Bukowski et al, 1995 ; Fengler and Abcarian, 1997) .
  • 29. A perineal approach to rectourethral fistula has been described in selected cases with good results.  Advocated by:  Bukowski et al, 1995.  Nyam and Pemberton, 1999.  Youssef et al, 1999.  Zmora et al, 2003.
  • 30. Advantages of perineal approach include: being a familiar approach for many urologists and local accessability to a variety of potential interpositional flaps.  Perineal approach with interpositional flap provided Excellent results.
  • 31. Interposition grafts include:  Gracilis muscle: Ryan et al, 1979 ; Rius et al, 2000 ; Zmora et al, 2003.  Pedicled dartos muscle: Venable, 1989 ; Youssef et al, 1999 ; Yamazaki et al, 2001.  Penile skin: Morgan, 1975.  levator muscle: Goodwin et al, 1958.  Bladder: Kokotas and Kontogeorgos, 1983.
  • 32.  patient in the extended lithotomy position.  a 20 F 30-ml filled balloon catheter is inserted.  Use retractors to bring fistula into the wound, and insert a finger into the rectum as a guide.  Divide the fistula and excise all surrounding scar tissue.
  • 33. assistant draw up on the catheter.  blunt and sharp dissection between the rectum and prostate well above the fistula to reach normal tissue.  Closure of the rectal fistula. ©
  • 34. Graft can be interposed between urethra & rectum esp. in teneous repair.  urethral defect is closed in two layers with 4-0 absorbable suture.
  • 35. Transabdominal approach has been described for URF rapair with limited success.  Advocated by:  Bukowski et al, 1995 ;  Nyam and Pemberton, 1999 ;  Shin et al, 2000.  The principal advantage to this technique is the availability of greater omentum for an interpositional flap.
  • 36. Potential disadvantages include:  morbidity and prolonged postoperative convalescence associated with a laparotomy incision  the poor exposure of the operative field  limited maneuverability in the deep pelvis  risk of urinary and fecal incontinence.
  • 37. Continue antibiotic administration and a low- residue diet postoperatively.  Shorten the drain in 3 days and remove it the next day.  Remove the catheter or cystostomy no sooner than the 8th day.
  • 38. Rectourethral fistulas are uncommon complication, it occur mostly after surgery, radiotherapy or minimally invasive treatments for prostatic cancer.  Rare causes include surgery for BPH,  rectourethral fistulas are usually suspected clinically and diagnosis can be confirmed with voiding cystourethrography or retrograde urethrogram. ©
  • 39. Treatment of rectourethral fistula most commonly involves surgical repair; however, select patients may respond to conservative therapy.  York-Mason approach have good results and minimal morbidity in cases not amenable to transanal approach.  Transperineal approach with interpositional graft is familiar with good results. ©