practical pathology

1. Pr.Dr. Magdy Ismael Ahmed

2. neutrophils lymphocyte Plasma cell macrophage

3. Mast cell eosinophil Giant cell Fibroblast

4. Collagen fibers

6. Appendicitis Definition :- Inflammation of appendix ( either acute or chronic) Etiology :- Predisposed by:- 1-Obstruction of its lumen or hyperplasia of lymphoid follicles. 2- Fibrosis of the wall Excited by infection with Strep.E.coli or staph. Pathology :- 1-Acute catarrhal appendicitis (edema,congestion ,serous fluid) 2-Acute suppurative appendicitis(filled by pus) 3-Acute gangrenous appendicitis(black in colour and offensive). Complications :- 1-Perforation  septic peritonitis (diffuse or localized) 2-Appendicular mass :- Fibrosis and adhesion with intestine and omentum 3-Appendicular abscess 4-Sinus & fistula 5-Portal pyemia

7. Pathology :- Gross picture Comment -The appendix  slightly enlarged ,congested and edematous . -The lumens are filled by inflammatory exudate -The serosa show dark spots of hemorrhages Diagnosis: Acute suppurative appendicitis.

16. Cloudy swelling of kidney

20. Specimen :- Section of liver Size :- enlarged Surface :-Smooth Capsule :-Thin ,stretched easily Streped Colour :- Yellowish Borders :- Rounded Consistency :- Soft D13

24. 2 nd of circular lesions

26. Atheroma Calcification Media crystals

28. Fibrin mass PNL,s Retraction space Lobar pneumonia grey hepatization

31. Blood vessels Edema Eosinophil Squamous metaplasia

34. Squamous cell carcinoma Fibrous septae Aot cell carcinoma Lung tissue

37. Squamous cell papilloma

38. Squamous cell papilloma

39. Squamous cell papilloma

40. Slide (12) Adenoma Definition :- A benign tumor of endocrine and exocrine glands and mucosal glands of GIT and endometrium. Gross picture :- A well –defined capsulated ovoid mass cut section : solid ,cystic or papillary cystic Microscopic picture :- Proliferated glands lined by cuboidal or columnar epithelium separated by a dense fibro-vascular connective tissue stroma (colon adenoma )

41. Adenoma

42. Adenoma

44. Pericanalicular fibroadenoma

45. Intracanalicular Fibroadenoma

47. Origin : arise from the fibrous tissue. Sites: Fibrous tissue stroma of organs (breast ,ovary and kidney) , intermuscular septa, submucosa, Grossly: capsulated, oval, soft (cellular) to hard and Cut section :- Whorly bundles grayish white (hard) or pinkish –white(cellular) in colour . Microscopically: bundles of mature fibroblasts, collagenous tissue, and few capillaries. If excess collagen  hard fibroma, if excess fibroblasts  soft fibroma. Types: - Pure fibroma.-Mixed fibroma, with glands  fibroadenoma, with muscles  fibromyoma Slide (14) : Fibroma

50. Slide (14) : Leiomyoma Origin: from smooth muscles. Sites: uterus is the most common (fibroid) GIT, bladder. Grossly: non capsulated (false capsule) , single or multiple, rounded, firm . C.S whorled pattern, composed of pinkish and whitish interlaced bundles . Microscopically: interlacing bundles of smooth muscle fibers separated by fibrovascular stroma.

58. Chondroma

62. SCC Cell nests Keratin pearls Lymphocytes

66. Basaloid cells Palisading Retracted stroma around the malignant masses

69. Adenocarcinoma colon Normal mucosa Malignant glands

70. Adenocarcinoma colon Normal mucosa Malignant glands

73. Mucoid carcinoma, colon Normal mucosa Mucus pools

75. Herring bone

77. Thank you