1. By: Tommy Sato

2. What are Gene (DNA) Vaccines?
 Gene (DNA) Vaccine (otherwise known as Gene
Therapy) is a way of creating antibodies in the human
body by injecting DNA vaccines into another.

3. History of Gene (DNA) Vaccine
 Since its early applications in the 1950's, DNA-based
immunization has become a novel approach to
vaccine development. Direct injection of naked
plasmid DNA induces strong immune responses to the
antigen encoded by the gene vaccine.

4. Current Use
 This method was effective in many of the big diseases
mentioned in our current date.
 Bird Flu
 West Nile Virus
 The mentioned above were mostly cured by the Gene
(DNA) Vaccine method.

5. Advantages
 Immune response focused only on antigen of interest
 Ease of development and production
 Stability of vaccine for storage and shipping
 Cost-effectiveness

6. Disadvantages
 Risk of affecting genes controlling cell growth
 Possibility of inducing antibody production against
DNA
 Possibility of tolerance to the antigen (protein)
produced

7. Methods of Implantation
 Injection (hypodermic needle)
 Pneumatic (Jet) Injection
 Gene Gun

8. Steps/Procedures
 1. Get the vaccine (DNA)
that you want to implant.
 2. Place the selected vaccine
in the gene gun (or any
implantation device).
 3. Inject the DNA into a
virus or infected area.
 4. The vaccine will replicate
and create antibodies.

9. Future Usage
 Gaining a full understanding of this mechanism of
DNA uptake could prove helpful in improving
applications for gene therapy and gene vaccination.
Both improved expression and better engineering of
the DNA plasmid may enhance antibody response to
the gene products and expand the applications of the
gene vaccines

10. The Difference between normal
vaccines, and DNA vaccines
 DNA Vaccine
 Cost-Efficient
 Safer
 Easy to develop/obtain
 Normal Vaccine
 Works only on the specified virus/disease
 Expensive
 Takes time to develop/obtain