12. A term covering a broad spectrum of entities that
induce inflammatory changes in the gastric
mucosa.
Neutrophilic infiltration
13. Pathology
Erosive
Non erosive
Where
Pangastritis
Antral gastritis
Pyloral gastritis
Fundus
14. Gastric mucosa demonstrates edema ,
neutrophilic infiltrates, mucosal erosion
if severe Ulceration and hemorrhage
15. Usually no symptoms
Pain(nondescript epigastric discomport)
Nausea
Anorexia
Vomit
Blood in vomit
Black , tarry stools
Heart burn
Pain in abdomen
16. We usually diagnose it by prevention
Endoscopy
Histology
+H.pylori diagnosis
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27. Chronic gastritis is defined as the presence of
chronic mucosal inflammatory changes leading
evetually to mucasal atrophy and intestinal
metaplasia, usually absence of erosion
29. Antibody againts parietal cell and IF(intrinsic
factor)
Pernicious anemia, Non pernicious anemia are
occurs
Parietal cell antibody direct againts H+,K+-
ATPase proton pump
HLA-B8 and DR3 gene found in patients
30. Caused by H.pylori (gramm-, curved rod) wich
produces urease, proteases, cytotoxins and
colonizes mucus layer lining
This is most common in chronic gastritis
Conversion to pangastritis require 15-20 years
Type B Chronic gastritis can be cause of cancer
but mechanism is not so clear