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Treatment of Fever
By: Ahmed Mohammed
Eweidah
No. 13
Faculty of Medicine,
Alexandria University
Rx of Fever
Non
Pharmacological
Pharmacological
Treatment of Fever
 Use tap or lukewarm water (29° to 32° C) to
sponge. Remove clothing's, cover the child with
towel sponge and dry his face.
 Apply the compresses to forehead,
nape of neck, armpits and groin.
Treatment of Fever
TEPID SPONGING
 Proceed to sponge body starting with the front
then to the back.
 Generally you should not sponge a child for more
than 30 minutes at a stretch. Stop sponging when
shivering occurs. When your child shivers, cover
him up and wait a while before resuming
sponging.
 Usually sponging will bring down the fever by
one to two degrees in 30-45 minutes.
Treatment of Fever
 Encouraging the child to take plenty of fluids.
 Dressing the child in light clothing to allow heat
exchange.
 Room environment is kept cool and well-
ventilated to allow the ambient
temperature to help bring
the fever down.
Treatment of Fever
Other Measures
 There are various reasons why we do not
recommend using tepid sponging:
 there is a lack of evidence to support its routine
use in temperate climates, because the sponging
does not produce a sustained drop in temperature
 It can lead to vasoconstriction, which can result
in a further rise in a child’s temperature.
Treatment of Fever
 If performed too quickly, sponging can cause a
child to shiver and have an increase in metabolic
rate.
 The process is also very time-consuming
for a nurse or caregiver.
Treatment of Fever
Sponging is preferred over
acetaminophen or
ibuprofen if:
 The child is known to be
allergic to, or is unable to
tolerate, antipyretic drugs
(a rare case).
Treatment of Fever
It is advisable to combine sponging with:
acetaminophen or ibuprofen if:
- Fever is making the child extremely
uncomfortable.
- He is vomiting and may not be able to keep the
medication in his stomach.
Treatment of Fever
Treatment of Fever
Pharmacological
Aspirin Acetaminophen Ibuprofen
The American Academy of Pediatrics has
recommended that children (through 21 years of
age) not take aspirin if they have chickenpox or
influenza (any cold, cough or sore throat
symptoms).
Treatment of Fever
Avoid Aspirin
 Children older than 2 months of age can be given
any one of the acetaminophen products. All have
the same dosage.
 Acetaminophen doses of 10 to 15 mg/kg per dose
given every 4 to 6 hours orally are generally
regarded as safe and effective. Typically, the onset
of an antipyretic effect is within 30 to 60
minutes; approximately 80% of
children will experience a decreased
temperature within that time.
Treatment of Fever
Acetaminophen (APAP)
Treatment of Fever
 Nausea, upper stomach pain, itching, loss of
appetite.
 Dark urine, clay-colored stools.
 Jaundice (yellowing of the skin or eyes).
Treatment of Fever
Side Effects
 All ibuprofen products are now available without
a prescription. Give the correct dosage every 6 to
8 hours as needed.
 Greater than 6 months to 12 years:
5 mg/kg/dose for temperature less than (39.2
degrees C) orally every 6 to 8 hours as needed.
10 mg/kg/dose for temperature greater than or
equal to (39.2 degrees C) orally every 6 to 8 hours
as needed.
Treatment of Fever
Ibuprofen Products
 Ibuprofen is a non-selective inhibitor of an
enzyme called cyclooxygenase (COX), which is
required for the synthesis of prostaglandins via
the arachidonic acid pathway. COX is needed to
convert arachidonic acid to prostaglandin H2
(PGH2) in the body. This PGH2 is then converted
to prostaglandins. The inhibition of COX by
ibuprofen therefore lowers the level of
prostaglandins made by the body.
Treatment of Fever
Mechanism of action
 The prostaglandins that are formed from PGH2
are important mediators of sensations such as
pain and processes such as fever and
inflammation. The antipyretic effects may arise as
a result of action on the hypothalamus leading to
vasodilation, an increased peripheral blood flow
and subsequent heat dissipation.
Treatment of Fever
Mechanism of action
 Nausea (feeling sick)
 Vomiting (being sick)
 Diarrhea.
 Indigestion (dyspepsia)
 Tummy (abdominal) pain.
Treatment of Fever
Common side effects of
ibuprofen
 According to WHO paracetamol is the drug of
first choice.
 Ibuprofen is a useful 2nd line drug.
 No other NSAID including Nimesulide should be
prescribed for children with high grade fever
(WHO 1990).
Treatment of Fever
Choice of Antipyretic
 Combining these medicines is not recommended for
the following reasons:
 No added benefit in reducing fever compared with
either product used alone. (Reason: both drugs have
the same mechanism of action.)
 Can cause dosage errors and poisoning (especially if
you give one product too frequently).
 No need to control fever this closely.
Treatment of Fever
 Use both if the fever is over 104° F (40° C) and
unresponsive to one medicine alone.
 Give a fever medicine every 4 hours (acetaminophen
every 8 hours and ibuprofen every 8 hours).
 Only alternate medicines for 24 hours or less, than
return to a single product.
Treatment of Fever
Alternative therapy
Treatment of Fever

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Treatment of Fever

  • 1. Treatment of Fever By: Ahmed Mohammed Eweidah No. 13 Faculty of Medicine, Alexandria University
  • 3.
  • 4.  Use tap or lukewarm water (29° to 32° C) to sponge. Remove clothing's, cover the child with towel sponge and dry his face.  Apply the compresses to forehead, nape of neck, armpits and groin. Treatment of Fever TEPID SPONGING
  • 5.  Proceed to sponge body starting with the front then to the back.  Generally you should not sponge a child for more than 30 minutes at a stretch. Stop sponging when shivering occurs. When your child shivers, cover him up and wait a while before resuming sponging.  Usually sponging will bring down the fever by one to two degrees in 30-45 minutes. Treatment of Fever
  • 6.  Encouraging the child to take plenty of fluids.  Dressing the child in light clothing to allow heat exchange.  Room environment is kept cool and well- ventilated to allow the ambient temperature to help bring the fever down. Treatment of Fever Other Measures
  • 7.  There are various reasons why we do not recommend using tepid sponging:  there is a lack of evidence to support its routine use in temperate climates, because the sponging does not produce a sustained drop in temperature  It can lead to vasoconstriction, which can result in a further rise in a child’s temperature. Treatment of Fever
  • 8.  If performed too quickly, sponging can cause a child to shiver and have an increase in metabolic rate.  The process is also very time-consuming for a nurse or caregiver. Treatment of Fever
  • 9. Sponging is preferred over acetaminophen or ibuprofen if:  The child is known to be allergic to, or is unable to tolerate, antipyretic drugs (a rare case). Treatment of Fever
  • 10. It is advisable to combine sponging with: acetaminophen or ibuprofen if: - Fever is making the child extremely uncomfortable. - He is vomiting and may not be able to keep the medication in his stomach. Treatment of Fever
  • 12. The American Academy of Pediatrics has recommended that children (through 21 years of age) not take aspirin if they have chickenpox or influenza (any cold, cough or sore throat symptoms). Treatment of Fever Avoid Aspirin
  • 13.  Children older than 2 months of age can be given any one of the acetaminophen products. All have the same dosage.  Acetaminophen doses of 10 to 15 mg/kg per dose given every 4 to 6 hours orally are generally regarded as safe and effective. Typically, the onset of an antipyretic effect is within 30 to 60 minutes; approximately 80% of children will experience a decreased temperature within that time. Treatment of Fever Acetaminophen (APAP)
  • 15.  Nausea, upper stomach pain, itching, loss of appetite.  Dark urine, clay-colored stools.  Jaundice (yellowing of the skin or eyes). Treatment of Fever Side Effects
  • 16.  All ibuprofen products are now available without a prescription. Give the correct dosage every 6 to 8 hours as needed.  Greater than 6 months to 12 years: 5 mg/kg/dose for temperature less than (39.2 degrees C) orally every 6 to 8 hours as needed. 10 mg/kg/dose for temperature greater than or equal to (39.2 degrees C) orally every 6 to 8 hours as needed. Treatment of Fever Ibuprofen Products
  • 17.  Ibuprofen is a non-selective inhibitor of an enzyme called cyclooxygenase (COX), which is required for the synthesis of prostaglandins via the arachidonic acid pathway. COX is needed to convert arachidonic acid to prostaglandin H2 (PGH2) in the body. This PGH2 is then converted to prostaglandins. The inhibition of COX by ibuprofen therefore lowers the level of prostaglandins made by the body. Treatment of Fever Mechanism of action
  • 18.  The prostaglandins that are formed from PGH2 are important mediators of sensations such as pain and processes such as fever and inflammation. The antipyretic effects may arise as a result of action on the hypothalamus leading to vasodilation, an increased peripheral blood flow and subsequent heat dissipation. Treatment of Fever Mechanism of action
  • 19.  Nausea (feeling sick)  Vomiting (being sick)  Diarrhea.  Indigestion (dyspepsia)  Tummy (abdominal) pain. Treatment of Fever Common side effects of ibuprofen
  • 20.  According to WHO paracetamol is the drug of first choice.  Ibuprofen is a useful 2nd line drug.  No other NSAID including Nimesulide should be prescribed for children with high grade fever (WHO 1990). Treatment of Fever Choice of Antipyretic
  • 21.  Combining these medicines is not recommended for the following reasons:  No added benefit in reducing fever compared with either product used alone. (Reason: both drugs have the same mechanism of action.)  Can cause dosage errors and poisoning (especially if you give one product too frequently).  No need to control fever this closely. Treatment of Fever
  • 22.  Use both if the fever is over 104° F (40° C) and unresponsive to one medicine alone.  Give a fever medicine every 4 hours (acetaminophen every 8 hours and ibuprofen every 8 hours).  Only alternate medicines for 24 hours or less, than return to a single product. Treatment of Fever Alternative therapy