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Michelle B. Kravitz, MD June 29, 2006 NEONATAL HYPERBILIRUBINEMIA
Case 1 ,[object Object],[object Object],[object Object]
Case 2 ,[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object]
BILIRUBIN ,[object Object],[object Object]
BILIRUBIN PHYSIOLOGY ,[object Object],[object Object],[object Object]
BILIRUBIN PHYSIOLOGY Heme Biliverdin Heme oxygenase Bilirubin Biliverdin reductase
Bilirubin Physiology ,[object Object],[object Object]
Enterohepatic Circulation ,[object Object],[object Object],[object Object]
Conjugation ,[object Object],[object Object],[object Object]
CONJUGATED VS UNCONJUNCATED HYPERBILI ,[object Object],[object Object],[object Object]
KERNICTERUS ,[object Object],[object Object],[object Object],[object Object],[object Object]
KERNICTERUS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
KERNICTERUS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
KERNICTERUS AND FREE BILIRUBIN ,[object Object],[object Object]
ALBUMIN ,[object Object],[object Object],[object Object]
ALBUMIN ,[object Object],[object Object]
RISK FACTORS FOR SIGNIFICANT JAUNDICE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TIME COURSE OF JAUNDICE ,[object Object],[object Object],[object Object]
RISK FACTORS-RACE ,[object Object],[object Object],[object Object],[object Object]
 
RISK FACTORS-GESTATIONAL AGE ,[object Object],[object Object],[object Object],[object Object]
RISK FACTORS-FAMILY HX ,[object Object],[object Object]
RISK FACTORS-HEMOLYSIS ,[object Object],[object Object],[object Object],[object Object]
RISK FACTORS-PATHOLOGIC ,[object Object],[object Object],[object Object],[object Object],[object Object]
BREASTMILK/BREASTFEEDING  JAUNDICE ,[object Object],[object Object],[object Object],[object Object]
BREASTMILK/BREASTFEEDING  JAUNDICE ,[object Object],[object Object],[object Object],[object Object],[object Object]
ASSESSING THE RISK OF JAUNDICE BY THE NUMBERS ,[object Object]
 
ASSESSING THE RISK OF JAUNDICE BY THE NUMBERS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Copyright ©2004 American Academy of Pediatrics Subcommittee on Hyperbilirubinemia,  Pediatrics 2004;114:297-316 Guidelines for phototherapy in hospitalized infants of 35 or more weeks' gestation
ASSESSING THE RISK OF JAUNDICE BY THE NUMBERS ,[object Object],[object Object]
THERAPIES-PHOTOTHERAPY ,[object Object],[object Object],[object Object]
THERAPIES-PHOTOTHERAPY ,[object Object],[object Object],[object Object]
THERAPIES-EXCHANGE TRANSFUSION ,[object Object],[object Object],[object Object]
THERAPIES-Sn Mesoporphyrin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THERAPIES-Sn Mesoporphyrin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Review of Case 1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Review of Case 2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MANAGING JAUNDICE-TAKE HOME POINTS ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
REFERENCES ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]

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Hyperbili kravitz

  • 1. Michelle B. Kravitz, MD June 29, 2006 NEONATAL HYPERBILIRUBINEMIA
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  • 7. BILIRUBIN PHYSIOLOGY Heme Biliverdin Heme oxygenase Bilirubin Biliverdin reductase
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  • 32. Copyright ©2004 American Academy of Pediatrics Subcommittee on Hyperbilirubinemia, Pediatrics 2004;114:297-316 Guidelines for phototherapy in hospitalized infants of 35 or more weeks' gestation
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