Modified version of an overview how we have organised our translational technology infrastructure as the Radboudumc Technology Centers and collaborate with external technology-focused infrastructures to drive our ambition towards implementing personalized healthcare.

1. Alain van Gool
Professor Personalized Healthcare
Head Translational Metabolic Laboratory
Strategic advisor of the executive board
30 Nov 2017
O&O conference, Radboudumc, Nijmegen
Radboudumc Technology Centers
as part of an academic technology network

2. A significant impact on healthcare
Innovation Building networks
Making choices Human Scale
2 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

3. Patient
Radboud
Personalized Healthcare
A significant impact
on healthcare
Molecule
Population
3 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

4. Orientation across the spectrum
from molecule to man to population
Orientationacross
thespectrumofdiseases
PI
Research ThemeTechnologyCenter
Research support by Technology
Paul Smits, O&O conference, October 2013
4 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

5. Radboudumc Technology Infrastructure
Get organised:
1. What technological expertise do we have and should we have ?
2. How should we organise this ?
3. How will we communicate this ?
Starting phase (2014) Forming phase (2014)
5 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

6. www.radboudumc.nl/research/technologycenters
Genomics
Bioinformatics
Animal
Research
facility
Stem
cells
Translational
neuroscience
Image-guided
treatment
Imaging
Microscopy
Biobank
Health
economics
Mass
Spectrometry
Radboudumc
Technology
Centers
Investigational
products
Clinical
studies
Health
data
Statistics
Human
performance
Data
stewardship
Molecule
Flow
cytometry
3D lab
(Nov 2014)
6 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

7. About 200 technology experts working in 19 Technology Centers, ~1800 users (internal, external), ~150 consortia
www.radboudumc.nl/research/technologycenters/7
• Proteins
• Metabolites
• Drugs
• PK-PD • Preclinical
• Clinical
• Behavioural
• Preclinical
• Animal facility
• Systematic review
• Cell analysis
• Sorting
• Pediatric
• Adult
• Phase 1, 2, 3, 4
• Vaccines
• Pharmaceutics
• Cyclotron
• Radio-isotopes
• Malaria parasites
• Management
• Analysis
• Sharing
• Cloud computing
• DNA
• RNA
• Internal
• External
• Early HTA
• Evidence-
based surgery
• Field lab
• Statistics
• Biological
• Structural
• Preclinical
• Clinical
• Economic
viability
• Decision
analysis
• Experimental design
• Biostatistical advice
• Hospital and GP
data handling and
analysis
• Big Data
• In vivo
• Functional
diagnostics
• iPSC
• Organoids
• 3D imaging
• 3D printing
• Virtual reality

8. Visibility
Combination of
• Science
• Business
• Innovation
• Impact in health
www.radboudumc.nl/research/technologycenters/
(1H2015: 1.900 unique visitors, 26.000 page views)

9. Netherlands technology networks
(local)
(NL nodes of European networks)
(national)
9 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

10. Radboud Research Facilities
• Shared facilities across Radboud campus, also made part of Gelderland facilities
• Initiated by funding 6.2M Eur Gelderland + 6.2M Eur Radboud University/ Radboudumc
www.ru.nl/radboudresearchfacilities/
Ed Koster
10 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

11. Dutch Techcenter for Life Sciences
•Ruben Kok
Barend Mons
Alain van Gool
Jaap Heringa
•Scientific leads:
•Operational team
www.dtls.nl
11 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

12. PARTNERSHIP FOR DATA, TECHNOLOGIES & LEARNING

13. DTL hotels @Radboudumc
www.dtls.nl
13 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

14. FOCUS ON CRITICAL COMPONENT: THE DATA
{Wilkinson et al, Nature Scientific Data, 2016}
Prof Barend Mons
Leiden University Medical Center
Dutch Techcenter for Life Sciences
 Data capture
 Data stewardship (FAIR)
14 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

15. 4. Connecting
Research
3. Access to data
and samples
2. Harmonize IT
Architecture
5. Clinical care data for
research
7. Facilities for high-
throughput data processing
1. Harmonize data
stewardship guidelines
6. Good Research
Practice
9. Access to
experts and support
Arnoud van der Maas
Alain van Gool
Jan Willem Boiten
data4lifesciences.nl
15 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

16. Link to European infrastructures
ec.europa.eu/research/infrastructures/pdf/esfri/esfri_roadmap/esfri_roadmap_2016_adopted.pdf
16 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

17. European infrastructures
@Radboudumc:
Peggy Manders
Gerhard Zielhuis
@Radboudumc:
Peter Friedl
Otto Boerman
@Radboudumc:
Otto Boerman (former Chair Imaging Platform)
Alain van Gool (Chair Biomarker Platform)
@Radboudumc:
Arnoud van der Maas
Ariaan Siezen
@Radboudumc:
Saskia de Wildt
Paul Smits
17 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

18. Collaboration towards Good Biomarker Practices
{van Gool et al, Nature Reviews Drug Discovery, Apr 2017}
COST action CA16113
http://clinimark.eu
18 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

19. 19 www.elixir-europe.org

20. ELIXIR-NL
• Embedded in DTL - Dutch Techcenter
for Life Sciences
• Public-private partnership
• Focus on data interoperability and
exchange, e-infrastructure services
and training
• www.dtls.nl/elixir-nl
2
0
Arnoud van der Maas
Ariaan Siezen

21. 21 eatris.eu

22. 22 eatris.eu
Alain van Gool

23. 23 eatris.eu
Alain van Gool

24. 24 www.bbmri-eric.eu

25. makes biomaterials, images and data from research
retrievable, accessible and exchangeable for research in
compliance with ethical, legal and privacy demands and
active participation of donors.
www.bbmri.nl
Gerhard Zielhuis
Peggy Manders

26. PSI covers 18 large disease
specific cohorts (the‘Pearls’)
within the areas of
• cancer,
• auto-immune diseases,
• metabolic disorders,
• Cardiovascular diseases
• neurologic disorders,
PSI uses a harmonized
infrastructure and
standardised procedures
is a collaborative biobanking platform of all eight
University Medical Centres
Current status
parelsnoer.org
Gerhard Zielhuis

27. www.eurobioimaging.eu

28. eurobioimaging.nl
28 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017
Peter Friedl

29. www.ecrin.org

30. 3.
PEDCRIN
Paediatric Clinical
Research Infrastructure Network
IMI2
European Pediatric
Clinical Trial Network
‘Best evidence’ dose
1. European Pediatric Formulary
2. EPTRI
European Paediatric
Translational
Research Infrastructure
(H2020 funded)
Saskia de Wildt

31. Save the date: 15 January 2018
Concept programme:
13.30 – 14.00 Arrival guests
14.00 – 15.00 Pitches by external network organizations
15.00 – 16.00 1-slide presentations by all RTC’s
16.00 – 17.30 Reception and matchmaking
Matchmaking event Radboudumc Technology Centers
31 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

32. 32 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017
Two particular Netherlands technology networks

33. NWO Large Scale Infrastructures
• Grant for large technology infrastructures
• 1H2016: inventory across Netherlands
• June 2016: presentation landscape analysis
• 2H 2016: clustering of similar technologies
• Dec 2016: presentation roadmap + follow-up path to ministery
• Dec 2016: call for proposals
• June 2017: submission proposals
• Jan 2018: interviews
• Mar 2018: granting of funding (45M life sciences)
Criteria roadmap facility:
• Need to be connected to an ESFRI (NL node)
• Mature
• Sustainable
• High science
• Professional service
33 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

34. Meeting Radboudumc Technology Centers, 8 July 2016
www.onderzoeksfaciliteiten.nl

35. NWO roadmap proposals
35
Outlines of 3 large cluster proposals Radboudumc is involved in:
- X-omics Marcel Nelen, Wynand Alkema, Alain van Gool (= lead)
- ELIXIR-NL Arnoud van der Maas (lead = Jaap Heringa)
- NL-Bioimaging-AM Peter Friedl (lead = Dorus Gadella)
35 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

36. The Netherlands X-omics Initiative
www.x-omics.nl
36 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

37. 37 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017
www.x-omics.nl

38. Roadmap Cluster: ELIXIR-NL
Cluster partners: DRE, euroCAT, ELIXIR-NL,
SURF (NLeSC)
DRE
Arnoud van der Maas
Ariaan Siezen
Andre Dekker
Philippe Lambin
Jaap Heringa
Chris Evelo
Rob Hooft
Axel Berg
Irene Nooren
www.dtls.nl/elixir-nl/roadmap/
38 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

39. ELIXIR-NL focus areas
Computing and storage: infra as a service
• create a digital research environment that seamlessly works
with the Dutch e-infrastructure
• provide researchers with customised help in storing and
managing their own data or searching and analysing other
people’s data
Interoperability and data exchange
• promote data exchange and data stewardship
based on FAIR principles
• implement and develop data capture standards,
software, semantic web standards, and formats
Training and education
• Training next generation of life scientists,
technologists and data experts, specialised in high-end
technologies, data stewardship, and FAIR principles
39 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

40. eurobioimaging.nl
40 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

41. 41 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

42. Health-RI

43. Origin Health-RI
43 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

44. Scope Health-RI
44 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

45. Building Health-RI
45 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017
Network Health-RI
Health-RI ecosystem
Health-RI organization
Non-exhaustive and to be extended (“inclusive network”)
Non-exhaustive (endorsed by >70 stakeholders)
?
?
These initiatives will launch and converge into the Health-RI platform
Health-RI consolidates the activities of multiple Dutch ESFRI
and e-infrastructure nodes into the Health-RI platform

46. Endorsed by >70 stakeholders

47. Recognized by authorities

48. Scope Health-RI
health-ri.org
48 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

49. health-ri.org49 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017

50. Acknowledgements
50 Alain van Gool, Radboudumc O&O conference, Nijmegen, 30 Nov 2017