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homeostasis physiology homeostasis in human body feedback regulation loop positive feedback mechanism negative feedback mechanism physiology pharmacology pathophysiology integrative physiology organismal physiology systems physiology molecular physiology cell physiology viral physiology microbial physiology plant physiology animal physiology human physiology applications of physiology jean fernel claudius galenus hippocrates physiology examples general physiology diabetes disease blood glucose regulation thermoregulation blood clotting components of feedback loop working of feedback loop thirst regulation examples of feedback loop types of feedback loop feedback mechanism homeostasis anatomy adaptations for homeostasis disruption in homeostasis organ system involved types of homeostasis example of homeostasis homeostasis