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MotyFania-Principal Architect, Intel
Parkinson Disease (PD)
The Hypothesis / Opportunity 
The problem – 
PD Big-Data is not really available 
Solution 
•Enable breakthroughs in Parkinson disease research through Big Data analytics 
•Small disparate sources of data 
•Most data is limited and unavailable 
•Instrument PD patients with wearable devices for large scale, continuous 24 X 7 data collection
Patients are not able to objectively evaluate their condition 
No Objective measure of Parkinson disease symptoms 
Cost of trials are in the scales of $M and they take several years to complete 
Very small number of patients contribute to research 
Researchers can not scale to large N due to technology limitations
30 
subjects 
5 
Days per Subject 
0.15TB 
Per Subject per Day 
500 
subjects 
30 
Days per Subject 
1GB 
Per Subject per Day 
15TB 
Every month 
1000 
subjects 
365 
Days per Subject 
Per Subject per Day 
365TB 
Every year
Smartphone App 
Big Data Analytics 
Wearable Monitor 
24 x 7 monitoring 
Objective measurements 
• 
Activity Identification 
• 
Anomaly Detection 
Location 
Movement 
Medications 
… 
Sleep Patterns 
Gait 
Balance 
Tremors 
Researcher 
physician 
Patient
7 
Cloud Infrastructure 
UI 
Data Platform 
Analytics Platform 
Datacenter 
Network 
Thing 
Services 
Gateway
2 Start an application 
1 Wear a watch
Activity recognition 
Activity characteristics 
symptoms identification 
Activity 
monitoring
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
Active
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
Active 
Low Movement
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
Active 
Low Movement 
Hand Movement
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
Active 
Low Movement 
Active
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
Active 
Low Movement 
Active 
Low Movement
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
Active 
Low Movement 
Active 
Low Movement 
Active
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00
10:00 
10:12 
10:24 
10:36 
10:48 
11:00 
10:00 
10:12 
10:24 
10:36 
10:48 
11:00
10:00 
10:12 
10:24 
10:36 
10:48 
11:00 
10:00 
10:12 
10:24 
10:36 
10:48 
11:00
Frequency ~5Hz –Typical to tremor 
3.5 
10.5 
17.5 
24.5 
31.5 
Time [sec]
Rest 
Leg Tremor Indication 
Rest 
Leg Tremor Ind. 
Rest 
3.5 
10.5 
17.5 
24.5 
31.5 
Time [sec]
8:00 
9:00 
10:00 
11:00 
12:00 
13:00 
8:00 
9:00 
10:00 
11:00 
12:00 
13:00
Sitting Down
Sitting Down 
Changing hand posture while sitting
Sitting Down 
Getting Up
Sitting Down 
Hand changes position to assist the movement 
Getting Up
Sitting Down 
Getting Up 
Measuring movements duration can indicate on slowness of movement
Sitting Down 
Getting Up 
Walking
Sitting Down 
Getting Up 
Walking 
Interrupts (e.g., turning around, handshake)
Sitting Down 
Getting Up 
Walking 
Changing hand posture while walking
Sitting Down 
Getting Up 
Walking 
70 Steps in average pace of 103 Steps per minute (in general, pace can indicate on slowness of movement)
Sitting Down 
Getting Up 
Walking 
Sitting Down
37 
~45 ServersLet’s look Inside
(Big) Data Ingestion 
Platform-as-a-Service (PaaS) for real-time data & event processing 
Analytics Services 
Monitoring & Alerting 
Data Visualization 
Reporting & Querying 
Advanced Analytics Services 
Time Series Analysis 
Anomaly / Change Detection 
Activity Recognition / Context Extraction 
Smart Cities 
Retail 
Industrial 
Transportation 
Health
Predictive Maintenance 
Inventory & Asset Mgmt. 
Cyber / Malicious Activity 
Mobile Health 
Load Balancing
Speed Layer 
Batch Layer 
Data 
Sources 
Ingestion 
Layer 
Servicing 
Layer
Configuration & MetaData 
Web Services 
Data Storage 
Analytics 
Rule Engine 
Web 
Site 
MQTT 
Node.js 
Express 
Angular.js 
Bootstrap 
Node.js 
Express 
MongoDB 
Message Broker 
Scala 
Java 
Akka 
Spray 
Apache Kafka 
Apache Phoenix 
Spark 
R 
ElasticLoad Balancing 
CDH 5.2 
YARN 
MapReduce 2 
HBase (time series) 
InfiniDB for AWS (aggregates) 
Cache 
Redis 
Deployment: 
AWS Cloud Formation 
OpsCodeChef 
Amazon VPC 
Monitoring: 
Nagios/ Zabbix 
Logging: 
Logstash 
Auto Scaling
Intel announced a comprehensive developer program for hobbyists, students and entrepreneurial developers with outreach, training and tools required to rapidly develop, test and deploy applications for the Internet of Things. 
•Package of easy to use hardware, software & tools, services 
•Global HackathonChallenge with prizes 
•20 City IoT Roadshow distributing 5,000 kits 
•University Program with courseware and labs starting with Carnegie Mellon 
•On-line community for learning, building sharing 
See Edison Live at the Intel Booth
You can use this platform to collect data and build your own solution with Edison!
http://bit.ly/awsevals

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(BDT209) Intel’s Healthcare Cloud Solution Using Wearables for Parkinson’s Disease Research | AWS re:Invent 2014

  • 3. The Hypothesis / Opportunity The problem – PD Big-Data is not really available Solution •Enable breakthroughs in Parkinson disease research through Big Data analytics •Small disparate sources of data •Most data is limited and unavailable •Instrument PD patients with wearable devices for large scale, continuous 24 X 7 data collection
  • 4. Patients are not able to objectively evaluate their condition No Objective measure of Parkinson disease symptoms Cost of trials are in the scales of $M and they take several years to complete Very small number of patients contribute to research Researchers can not scale to large N due to technology limitations
  • 5. 30 subjects 5 Days per Subject 0.15TB Per Subject per Day 500 subjects 30 Days per Subject 1GB Per Subject per Day 15TB Every month 1000 subjects 365 Days per Subject Per Subject per Day 365TB Every year
  • 6. Smartphone App Big Data Analytics Wearable Monitor 24 x 7 monitoring Objective measurements • Activity Identification • Anomaly Detection Location Movement Medications … Sleep Patterns Gait Balance Tremors Researcher physician Patient
  • 7. 7 Cloud Infrastructure UI Data Platform Analytics Platform Datacenter Network Thing Services Gateway
  • 8. 2 Start an application 1 Wear a watch
  • 9.
  • 10. Activity recognition Activity characteristics symptoms identification Activity monitoring
  • 11.
  • 12. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00
  • 13. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00 Active
  • 14. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00 Active Low Movement
  • 15. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00 Active Low Movement Hand Movement
  • 16. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00 Active Low Movement Active
  • 17. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00 Active Low Movement Active Low Movement
  • 18. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00 Active Low Movement Active Low Movement Active
  • 19. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00
  • 20. 10:00 10:12 10:24 10:36 10:48 11:00 10:00 10:12 10:24 10:36 10:48 11:00
  • 21. 10:00 10:12 10:24 10:36 10:48 11:00 10:00 10:12 10:24 10:36 10:48 11:00
  • 22. Frequency ~5Hz –Typical to tremor 3.5 10.5 17.5 24.5 31.5 Time [sec]
  • 23. Rest Leg Tremor Indication Rest Leg Tremor Ind. Rest 3.5 10.5 17.5 24.5 31.5 Time [sec]
  • 24. 8:00 9:00 10:00 11:00 12:00 13:00 8:00 9:00 10:00 11:00 12:00 13:00
  • 25.
  • 27. Sitting Down Changing hand posture while sitting
  • 29. Sitting Down Hand changes position to assist the movement Getting Up
  • 30. Sitting Down Getting Up Measuring movements duration can indicate on slowness of movement
  • 31. Sitting Down Getting Up Walking
  • 32. Sitting Down Getting Up Walking Interrupts (e.g., turning around, handshake)
  • 33. Sitting Down Getting Up Walking Changing hand posture while walking
  • 34. Sitting Down Getting Up Walking 70 Steps in average pace of 103 Steps per minute (in general, pace can indicate on slowness of movement)
  • 35. Sitting Down Getting Up Walking Sitting Down
  • 36.
  • 37. 37 ~45 ServersLet’s look Inside
  • 38. (Big) Data Ingestion Platform-as-a-Service (PaaS) for real-time data & event processing Analytics Services Monitoring & Alerting Data Visualization Reporting & Querying Advanced Analytics Services Time Series Analysis Anomaly / Change Detection Activity Recognition / Context Extraction Smart Cities Retail Industrial Transportation Health
  • 39. Predictive Maintenance Inventory & Asset Mgmt. Cyber / Malicious Activity Mobile Health Load Balancing
  • 40. Speed Layer Batch Layer Data Sources Ingestion Layer Servicing Layer
  • 41. Configuration & MetaData Web Services Data Storage Analytics Rule Engine Web Site MQTT Node.js Express Angular.js Bootstrap Node.js Express MongoDB Message Broker Scala Java Akka Spray Apache Kafka Apache Phoenix Spark R ElasticLoad Balancing CDH 5.2 YARN MapReduce 2 HBase (time series) InfiniDB for AWS (aggregates) Cache Redis Deployment: AWS Cloud Formation OpsCodeChef Amazon VPC Monitoring: Nagios/ Zabbix Logging: Logstash Auto Scaling
  • 42. Intel announced a comprehensive developer program for hobbyists, students and entrepreneurial developers with outreach, training and tools required to rapidly develop, test and deploy applications for the Internet of Things. •Package of easy to use hardware, software & tools, services •Global HackathonChallenge with prizes •20 City IoT Roadshow distributing 5,000 kits •University Program with courseware and labs starting with Carnegie Mellon •On-line community for learning, building sharing See Edison Live at the Intel Booth
  • 43.
  • 44.
  • 45.
  • 46. You can use this platform to collect data and build your own solution with Edison!
  • 47.