This public health–focused session explores the innovative IoT and mobile solutions in medical and life sciences and the public health arena. Delivering on this innovation requires the ability to collect, store, analyze, and cross-reference data. Attend this session to hear from organizations committed to take action and deliver results for their patients.

1. © 2016, Amazon Web Services, Inc. or its Affiliates. All rights reserved.
Sri Elaprolu, Sr. Manager, Solutions Architecture, AWS
Gari Clifford, Interim Chair, Dept. of Biomedical Informatics, Emory University
Prad Prasoon, Business Technology Strategist, American Heart Association
June 21, 2016
Health Solutions at the Edge: Mobile
and IoT for Life Sciences

2. © 2016, Amazon Web Services, Inc. or its Affiliates. All rights reserved.
Gari Clifford, Interim Chair, Dept. of Biomedical Informatics
Emory University and Georgia Institute of Technology
June 21, 2016
Scalable mHealth Using
the Amazon Cloud
The Health aging Study @ Emory
& the eCohort at Morehouse School of Medicine

3. The massive burden of brain disease
*Data from CDC, NIH, and NGO
~18.8 million (9.5% of US adult population in a given year) with major depression - #1 cause of
disability ages 15 – 45 at >$160 B costs annually
~7.7 million with posttraumatic stress disorder (PTSD) at cost of $42 B annually in US
~5.4 million people have Alzheimer’s disease at cost > $200 B annually in US
~13% of those over 60 years of age report confusion or memory loss
~4.6 million stroke survivors, with 800,000 new strokes annually at a cost of $43 B in US - #1
cause of long-term disability
~2.5 million people with TBI at a cost of $77 B annually in US
~2 million people have Epilepsy at a cost of $16 B annually in US
~1.5 million have Parkinson’s disease at cost of $23 B annually in US
By 2030, the United States population aged 65 years and older will double and the 71 million
older Americans will make up approximately 20% of the total population

4. Emory’s Healthy
Aging Study

5. Alzheimer's biomarkers: The Healthy Aging Study
• Goizueta Foundation $25 million transformational gift
• The challenge: identify predictive AD biomarker during middle age (who, when)
• The opportunity: 100,000 patients as partners –> the Emory Healthy Aging Study
• Extensive phenotyping of health – from MRI to mHealth

6. Large scale mHealth …
• Use physiology patches and actigraphy meters –
• Jawbone, Simband, Pebble, etc
• ECG/activity/EEE/O2 patches
• Natural behavioral data scraping
• Smartphone (accelerometer, gyro, GPS, SMS)
• Telecom records
• “Off body” sensors
• Video cameras (e.g. sleep)
• “Exposomes” – R Pi, Grove sensors, Sensly, …
• Satellite data (sleep)

7. Sleep, activity, and mental health

8. Social networking, geography, and movement
• ↑social network & ↓activity = physical illness
• ↓social network & ↓activity = mental illness

9. Location: Context is essential

14. The Healthy Aging app
• Initial architecture up for
• Salesforce integration
• iOS and Android devices
• Server-side communications with sales force
• Data security
• Data flow to AWS and other DBs
• Parent app development
• Fitbit/Jawbone connectors
• Layout and functionality of multiple games

15. mobile client
Emory data
center
1. Phone connects to API
on Amazon EC2 within
load balanced VPC
2. AWS app
validates user
against Salesforce
3. Salesforce
returns valid user
information
4. AWS uses validated user data
from Salesforce to lookup and
retrieve certificate from Emory
5. Emory returns the certificate
to the application via AWS to
encrypt memory on phone
Data flow
6. App uploads
continuous data to
Amazon S3 project
bucket every 3+
hours

16. virtual private cloud – 10.0.0.0/16
Availability Zone #1
SSH
Jump Box
VPC NAT
gateway
Public subnet – 10.0.1.0/24
Availability Zone #2 Availability Zone #3 Availability Zone #n
Elastic Load Balancer
web
server
web
server
security group
Auto Scaling group
RDS DB
instance
RDS DB
instance standby (multi-AZ)
Private 10.0.5.0/24Private 10.0.4.0/24Private 10.0.3.0/24
Availability Zone #n
Public 10.0.2.0/24
AWS Cloud Architecture

17. The Healthy Aging app
– a longitudinal tool for life …

18. Emory’s
Healthy
Aging
Study

19. © 2016, Amazon Web Services, Inc. or its Affiliates. All rights reserved.
Prad Prasoon, Business Technology Strategist,
American Heart Association
6.21.2016
HEALTH TECHNOLOGY
INNOVATION NEEDS

20. SAVING LIVES
FOR OVER 90 YEARS!

21. “TO IMPROVE THE
CARDIOVASCULAR HEALTH OF ALL AMERICANS BY
WHILE ALSO CONTINUING
TO DECREASE DEATHS FROM
CARDIOVASCULAR DISEASES AND STROKE
20%
202020% BY
THE YEAR

22. WHAT REALLY IMPACTS THE HEART
Every 25SECONDSsomeone has a Heart attack
1 3in DEATHS is caused by Cardiovascular disease
The US
spends 2.6TRILLION on health care Each year
82.6 MILLION American adults are living today with some
form of Cardiovascular disease

23. WHAT PEOPLE
WANT TO DO…

24. WHAT PEOPLE
HAVE TO DO…

25. CHANGING THE GAME

27. Connected
health is
changing the
relationship
between
healthcare
provider and
patient

28. MOBILE APPS ARE BECOMING A REGULAR PART OF PATIENT CARE
Source Pricewaterhouse Coopers :http://blog.doctorbase.com/top-10-health-industry-issues-2015-explained-infograp

29. THE WEARABLES MARKET CONTINUES TO GROW
Source: Wall Street Journal - http://www.wsj.com/article_email/the-future-of-the-wearables-market-1452736738-lMyQjAxMTA2MDAyODYwM

30. SHARE OF DIGITAL HEALTH APP MARKET AND PATIENT PREFERENCES
Source: Deloitte 2015 - http://raconteur.net/healthcare/self-service-healthcare-now-possible-with-mobile-techno

31. PATIENT
PERSPECTIVE
CLINICAL
PERSPECTIVE

32. LEVERAGING THE TECHNOLOGY FOR PATIENT ENGAGEMENT

33. TRANSFORMING CARE AND RESEARCH

34. Life is why…

35. Thank you!