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Membrane transport
by
E.ANANTHARAJ,1st msc ,cas in botany
University of madras
Introduction;
The plasma membrane is a selectively permeable barrier
between the cell and the extracellular environment.
Its permeability properties ensure that
essential molecules such as ions, glucose, amino acids, and
lipids readily enter the cell, metabolic intermediates remain
in the cell, and waste compounds leave the cell.
Movement of
virtually all molecules and ions across cellular membranes
is mediated by selective membrane transport proteins embedded
in the phospholipid bilayer.
Passive transport
Passive Transport
A process that does not require energy to move
molecules from a HIGH to LOW concentration

 Diffusion
 Facilitated Diffusion
 Osmosis
• Diffusion is the movement of small particles across a
selectively permeable membrane like the cell membrane
until equilibrium is reached.
These particles move from an area of high concentration
to an area of low concentration.
outside of cell

inside of cell
• Facilitated Diffusion is the movement of larger
molecules like glucose through the cell membrane –
larger molecules must be “helped”
Proteins in the cell membrane form channels for large
molecules to pass through

Proteins that form channels (pores) are called protein
channels

outside of cell

inside of cell

Glucose molecules
• Osmosis is the diffusion of water through a selectively
permeable membrane like the cell membrane
Water diffuses across a membrane from an area of high
concentration to an area of low concentration.

Semi-permeable
membrane is
permeable to water,
but not to sugar
Active Transport
• Cells may need to move molecules against concentration
gradient
– shape change transports solute from
one side of membrane to other
– protein “pump”
conformational change
– “costs” energy = ATP
low

ATP

high

“The Doorman”
Active transport
• Many models & mechanisms
ATP

ATP

antiport

symport
summery
Passive Transport
Process

Energy Source

Example

Simple diffusion

Kinetic energy

Movement of O2 through
membrane

Facilitated
diffusion

Kinetic energy

Movement of glucose into cells

Osmosis

Kinetic energy

Movement of H2O in & out of
cells

Filtration

Hydrostatic
pressure

Formation of kidney filtrate
Active Transport
Process

Energy Source

Example

Active transport of solutes

ATP

Movement of ions across
membranes

Exocytosis

ATP

Neurotransmitter secretion

Endocytosis

ATP

White blood cell phagocytosis

Fluid-phase endocytosis

ATP

Absorption by intestinal cells

Receptor-mediated
endocytosis

ATP

Hormone and cholesterol
uptake

Endocytosis via caveoli

ATP

Cholesterol regulation

Endocytosis via coatomer
vesicles

ATP

Intracellular trafficking of
molecules
REFERENCES
Books ;
.1.Molecular cell biology 5th edition .Lodish et.al
2.p.s verma &v.k agarwal

Online source;
1,www.biology junction.com
2,www.uma.maine.edu
3,www.ocuy.org.

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active and passive transport of plasma membrane

  • 1. Membrane transport by E.ANANTHARAJ,1st msc ,cas in botany University of madras Introduction; The plasma membrane is a selectively permeable barrier between the cell and the extracellular environment. Its permeability properties ensure that essential molecules such as ions, glucose, amino acids, and lipids readily enter the cell, metabolic intermediates remain in the cell, and waste compounds leave the cell. Movement of virtually all molecules and ions across cellular membranes is mediated by selective membrane transport proteins embedded in the phospholipid bilayer.
  • 3. Passive Transport A process that does not require energy to move molecules from a HIGH to LOW concentration  Diffusion  Facilitated Diffusion  Osmosis
  • 4. • Diffusion is the movement of small particles across a selectively permeable membrane like the cell membrane until equilibrium is reached. These particles move from an area of high concentration to an area of low concentration. outside of cell inside of cell
  • 5. • Facilitated Diffusion is the movement of larger molecules like glucose through the cell membrane – larger molecules must be “helped” Proteins in the cell membrane form channels for large molecules to pass through Proteins that form channels (pores) are called protein channels outside of cell inside of cell Glucose molecules
  • 6. • Osmosis is the diffusion of water through a selectively permeable membrane like the cell membrane Water diffuses across a membrane from an area of high concentration to an area of low concentration. Semi-permeable membrane is permeable to water, but not to sugar
  • 7. Active Transport • Cells may need to move molecules against concentration gradient – shape change transports solute from one side of membrane to other – protein “pump” conformational change – “costs” energy = ATP low ATP high “The Doorman”
  • 8. Active transport • Many models & mechanisms ATP ATP antiport symport
  • 9. summery Passive Transport Process Energy Source Example Simple diffusion Kinetic energy Movement of O2 through membrane Facilitated diffusion Kinetic energy Movement of glucose into cells Osmosis Kinetic energy Movement of H2O in & out of cells Filtration Hydrostatic pressure Formation of kidney filtrate
  • 10. Active Transport Process Energy Source Example Active transport of solutes ATP Movement of ions across membranes Exocytosis ATP Neurotransmitter secretion Endocytosis ATP White blood cell phagocytosis Fluid-phase endocytosis ATP Absorption by intestinal cells Receptor-mediated endocytosis ATP Hormone and cholesterol uptake Endocytosis via caveoli ATP Cholesterol regulation Endocytosis via coatomer vesicles ATP Intracellular trafficking of molecules
  • 11. REFERENCES Books ; .1.Molecular cell biology 5th edition .Lodish et.al 2.p.s verma &v.k agarwal Online source; 1,www.biology junction.com 2,www.uma.maine.edu 3,www.ocuy.org.