Más contenido relacionado La actualidad más candente (20) Infarct3. Definition
•Infarct is an area of ischemic necrosis
caused by occlusion of either the arterial
supply or the venous drainage
4. Causes
1. Thrombotic or Embolic arterial occlusion
2. Local vasospasm
3. Hemorrhage into the atheromatous plaque
4. Extrinsic vessel compression by tumour
5. Torsion of vessels
6. Traumatic rupture
7. Anterior compartment syndrome
6. Colour
Pale or Anemic Red or Hemorrhagic
d/e Arterial occlusion d/e Pulmonary arterial occlusion
Compact organs Arterial or Venous occlusion
End artery blood supply soft tissue
Eg: Kidney, Heart, Spleen Dual blood supply
Eg : Lungs , Intestine
7. Age
Recent or fresh Old or Healed
Slightly elevated over the surface Shrunken or
Depressedunder
the surface
9. Pathogenesis
Local hyperemia
Affected part becomes edema & hemorrhage
Cellular changes- Reversible cell injury
Progressive Proteolysis
Acute inflammatory reaction & Hyperemia
Blood pigments
Growth of granulation tissue
Infarct replaced by fibrous tissue
10. Morphology – Gross
• Wedge shaped
• Apex pointing towards occluded artery
• Base on the surface
• Arterial occlusion- Pale
• Venous occlusion – Hemorrhagic
11. Microscopy
• Pathognomic – Coagulative necrosis ( all organs)
• Cerebral infarcts – Liquefactive necrosis
• Periphery of the infarct- Inflammatory reaction noted
• Generally infarct replaced by fibrous tissue
• Cerebral infarct – Gliosis ( replacement by microglial cells)
16. Most commonly affected organs
Location Gross Outcome
Myocardium Pale Frequently lethal
Lungs Hemorrhagic Less fatal
Cerebrum Hemorrhagic or pale Fatal if massive
Intestine Hemorrhagic Frequently lethal
Renal Pale No lethal
Spleen Pale Not lethal
Liver Pale Not lethal
Lower extremities Pale Not lethal