Modern Genreation chemotherapeutic ways to combat cancer and showing minimal side effects as compared to traditional chemotherapeutic administration

1. -Arunaksha Chakraborty
-B.Pharm 3rd Year 6th Sem
Mentor
-Ast. Prof. Swarupananda
Mukherjee

2. Introduction
Overview
Preventive approach
Cancer treatment
Applications
Advantages
Disadvantages
Future
conclusion
DEAD
TUMOR
CELLS

3.  Nanotechnology will change the very foundations of cancer
diagnosis, treatment, and prevention.
 If we take an imaginative approach. Of course, this is quite logical,
 Since everything around us is made up of atomic and molecular
matter
 All of our problems are ultimately rooted in atomic and molecular
arrangements. Nanotechnology has at last provided a way for us to
rearrange and restructure matter on an atomic scale, allowing us to
reach down to the very roots of any problem

4. Nano Particles
 Nanotechnology is the
engineering of functional
systems at the molecular
scale.
 Nano refers to the 10-9
power, or one billionth. .For
comparison, a human hair is
about 100,000 nanometers
thick.
 The word itself is a
combination of nano, from
the Greek “nanos” (or Latin
“nanus”), meaning “Dwarf”,
and the word "Science”.
Relevant Comparisons
Water
molecule
White
blood cell
Tennis
ball

5. Most animal cells are
10,000 to 20,000
nanometers in diameter.
 nanoscale devices (less
than 100 nanometers) can
enter cells and the
organelles inside them to
interact with DNA and
proteins. Tools developed
through nanotechnology
may be able to detect
disease in a very small
amount of cells or tissue.
They may also be able to
enter and monitor cells
within a living body.
NanoparticlesAre
SmallEnoughtoEnterCells
Cell
White blood
cell
Nanodevices
Nanoparticles

6.  Cancer is a class of diseases characterized by out-of-control cell growth.
There are over 100 different types of cancer, and each is classified by the
type of cell that is initially affected.
 Cancer harms the body when damaged cells divide uncontrollably to form
lumps or masses of tissue called tumors.
 Tumor cells are basically two types.
 A tumor cell is part of a tissue that is abnormally growing. It may be either
malignant or benign in nature
Liver
cancer

7. NanoBiotechnology Imaging Physical Exam,
Symptoms

8. Chemo is
so easy
Back
to
work

9. Gold nanoparticles (GNP) are emerging as
promising agents for cancer therapy and are
being investigated as drug carriers,
photothermal agents, contrast agents and
radiosensitisers. Due to its small size, high
surface area ratio and being chemically inert
gold acts as an active vehicle which binds
specifically to the tumor cell. The main
advantage of GNPs is that they minimize the
toxicity of the anti cancer drugs. Research
studies have sighted that gold nanoparticles
produce covalent bond with the cytotoxic drug
and don’t react with any other molecule.
Targeted cell therapy is achieved in GNP drug
delivery system and special interaction
between light matters at right wavelength
turns gold nanoparticle into precise cancer cell
killers. Infra red light is used to oscillate the
gold nanoparticles attached with the cancer
cell and the energy formed due to oscillation as
heat and at sudden temperature increase kills
the cancer cell. This review work displays the
applications of gold nanoparticles as targeted
drug delivery tools for the cancer therapy.

11. Gold nanoparticle is simple for diagnosis.
It is less invasive.
It is provides increased contrast for diagnosis of oral
cancer.
It is nontoxic to human beings.
It does not photo bleaching or blinking which is
inherent to many other fluorophores.

12.  Reticuloendothelial system gets affected in presence
of gold nanoparticle
 Bit expensive
THAT’S IT

14.  Parvesh Sharma, Scott C Brown, NiclasBengtsson, et al. Gold-
nanoparticle.
 Helcher, H. H.AurumPotabileoder Gold Tinstur; J.
HerbordKlossen: Breslau and Leipzig, 1718.
 WeiboCai, Ting Gao, Hao Hong, et al. Applications of
goldnanoparticles in cancer nanotechnology. Nanotechnology,
Science and Applications 2008;1:17-32.
 Huang X, El-Sayed IH, Qian W, El-Sayed MA. Cancer cell
imaging and photo thermal therapy in the nearinfraredregion by
using gold nanorods. J Am ChemSoc 2006;128:2115–20.Gold
Nanorod Antennas for Ultra selective Tumor Ablation.
 Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases.
Nature 2000;407:249^57.
 RisauW. Angiogenesis and endothelial cell
function.Arzneimittelforschung1994;44:1141^6.