2010 (Oct) Canadian Diabetes Association Conference, poster presentation by BRAID Research

1. Diabetes and Cardiovascular Risk inDiabetes and Cardiovascular Risk in
Driftpile First Nation: Longitudinal ResultsDriftpile First Nation: Longitudinal Results
Kelli RalphKelli Ralph--Campbell, Richard T. Oster, Ellen L. Toth, BRAID Diabetes ResearCampbell, Richard T. Oster, Ellen L. Toth, BRAID Diabetes Research Group, University of Alberta, Edmonton, AB;ch Group, University of Alberta, Edmonton, AB;
Florence Willier, Paulette Campiou, Trina Scott, Driftpile FirstFlorence Willier, Paulette Campiou, Trina Scott, Driftpile First Nation, ABNation, AB
Abstract
The longitudinal BRAID1 study has been ongoing in Driftpile First
Nation since 2003. Approximately 52% of the population residing in
Driftpile (Canada Census, 2006) has been screened for diabetes
and cardiovascular risk, of whom 34% returned for at least one
follow-up visit. Our purpose was to examine, longitudinally,
diabetes-related risk factors among returning individuals.
Clinical and anthropometric measurements (blood glucose,
hemoglobin A1c, cholesterol, blood pressure, weight, height, body
mass index, waist circumference) were collected for adults and
children (ages 6-17) without known diabetes, and recorded in a
clinical database. A general linear mixed effects model was applied
to get overall trend estimates for each risk factor longitudinally.
Among adults (N=91), BMI, cholesterol (total), and blood pressure
did not change, and waist increased significantly. A1c tended to
increase (p-value = 0.05). At baseline 18% of adults tested were
identified with pre-diabetes (fasting plasma glucose 6.1-6.9
mmol/L), and 4% were identified with probable diabetes (FPG
>/=7.0 mmol/L) (CDA-CPGs 2008). Among children (N=33): BMI
and blood pressure percentiles, A1c and cholesterol (total) all
increased, though only BMI did so significantly.
For those who have had at least one follow-up visit, results-over-
time are not encouraging. Despite more than seven years of
surveillance, and numerous prevention and activity initiatives and
infrastructure implemented within the community, the risk for
diabetes does not appear to be decreasing.
1Believing we can Reduce Aboriginal Incidence of Diabetes
Dr. Ellen L. Toth,
BRAID Medical Lead
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Adults without known diabetes, N = 91Adults without known diabetes, N = 91 Children without known diabetes, N = 33Children without known diabetes, N = 33
BMI, cholesterol (total), andBMI, cholesterol (total), and
blood pressure did not change,blood pressure did not change,
and waist increasedand waist increased
significantly,significantly,
Among adults, A1c tended toAmong adults, A1c tended to
increase (pincrease (p--value = 0.05). Atvalue = 0.05). At
baseline 18% of adults testedbaseline 18% of adults tested
were identified with prewere identified with pre--
diabetes (fasting plasmadiabetes (fasting plasma
glucose 6.1glucose 6.1--6.9 mmol/L), and6.9 mmol/L), and
4% were identified with4% were identified with
probable diabetes (FPG >/=7.0probable diabetes (FPG >/=7.0
mmol/L).mmol/L).
Among children (N=33), all
parameters increased, with
BMI and waist achieving
statistical significance
Significance =
0.05
Sig: 0.674
Sig.: 0.016
Sig.: 0.437
Sig.:
0.513
Sig.:
0.100
Sig.:
0.00
Sig.:
0.052
Sig.:
0.975
Sig.:
0.351
Sig.:
0.62
Sig.:
0.764
Sig.:
0.00
Sig.:
0.00