2. Rheumatoid arthritis is
autoimmune disorder in
which Immune system
identifies the synovial
membrane as "foreign"
and begins attacking it.
Synovial membrane shown in
picture
3. Rheumatoid Arthritis (RA) is a chronic
inflammatory disorder that may affect many
tissues and organs, but mainly attacks the
joints producing an inflammatory synovitis.
4.
5.
6. Idiopathic
Positive family history
Inherited tissue type major
histocompatibility complex (MHC) antigen
Smoking
Bacterial and Fungal Infection
Herpes simplex virus infections
Epstein-Barr virus (EBV)
Vitamin D deficiency
7. RA affects 0.5-1.0% of population in USA
Females > males 3:1
but people of any age can be affected
Peak age 45-65 but onset early from age 20-45
yrs
About 75% of these are women.
The disease strikes women three times more
often than men
8. Presentation of antigen to T cells
T- and B-cell Proliferation Angiogenesis in
synovial lining
Neutrophil accumulation in synovial fluid.
Synovitis.
Early pannus Formation(The pannus is a
sheet of inflammatory granulation tissue that
spreads from the synovial membrane and
invades the joint)
9. Subchondral bone erosion.
Pannus invasion of cartilage Chondrocyte
proliferation.
Laxity of ligaments
Joint instability, contractures, decreased
ROM, systemic complications
11. The joints of the
hands are often the
very first joints
affected by
rheumatoid arthritis.
These joints are
swollen red and
tender when
squeezed.
Swelling due to synovitis
12.
13.
14. The deformity arises
from hyperextension
of the proximal
interphalangeal joint,
while the distal
interphalangeal joint
is flexed.
15.
16. Mallet finger is a
simple flexion
deformity of the
distal
interphalangeal
joint preventing
extension.
19. Joint stiffness
Loss of joint range of motion
Many joints affected (polyarthritis)
Limping
Joint deformity
Both sides of the body affected (symmetric)
21. X Rays
X rays of hands and feet are generally performed in
people with RA.
Magnetic Resonance Imaging (MRI)
Ultrasounds
22. Blood Tests
Rheumatoid Factor (RF)
RF is a specific antibody in the blood.
A negative RF does not rule out RA. The arthritis is then called
seronegative, most common during the first year of illness and
converting to seropositive status over time.
Anti-citrullinated Protein Antibodies (ACPAs)
Like RF, this testing is only positive in a proportion of all RA
cases.
Unlike RF, this test is rarely found positive if RA is NOT present,
giving it a specificity of about 95%.
23. Other blood tests performed when RA is suspected:
Erythrocyte Sedimentation Rate (ESR)
The rate at which red blood cells precipitate in a 1
hour period.
C-Reactive Protein
A protein found in the blood in response to
inflammation.
Full Blood Count
Gives information about all blood cells.
Renal Function
Kidney Function
Liver Enzymes
Gives information on the state of a patient’s liver
27. Gold-containing compounds
Action: Inhibits T- and B-cell activity, suppresses
synovitis during active stage of rheumatoid
aurothioglucose (Solganol)
gold sodium thiomalate
auranofin (Ridaura)
sulfasalazine (Azulfidine)
penicillamine (Cuprimine)
28. Immunosuppressives
Action: Immune suppression, effects DNA
synthesis and other cellular effects
methotrexate (Rheumatrex)
azathioprine (Imuran)
cyclophosphamide (Cytoxan)
29. Corticosteroids
Action: Anti-inflammatory, analgesic Used
for shortest duration and at lowest dose
possible to minimize adverse effects
prednisone
prednisolone
hydrocortisone
intra-articular injections
31. Surgeries considered for people who
have severe rheumatoid
arthritis include:
Arthroplasty, to replace part or all of a joint, such
as the hip or knee.
Arthroscopy, which uses a small lighted instrument
to remove debris or inflamed tissue from a joint.
Carpal tunnel release, to relieve pressure on the
median nerve in the wrist.
32. Cervical spinal fusion, to treat severe neck
pain and nerve problems.
Finger and hand surgeries, to correct joint
problems in the hand.
Foot surgery such as phalangeal head
resection.
Synovectomy, to remove inflamed joint
tissue.
33. NURSING DIAGNOSES
• Acute and chronic pain related to inflammation
and increased disease activity, tissue damage,
fatigue, or lowered tolerance level
• Fatigue related to increased disease activity,
pain, inadequate sleep/rest, deconditioning,
inadequate nutrition, emotional
stress/depression
• Disturbed sleep pattern related to pain,
depression, and medications
•
• Self-care deficits related to contractures,
fatigue, or loss of motion
34. Impaired physical mobility related to
decreased range of motion, muscle
weakness, pain on movement, limited
endurance, lack of or improper use of
ambulatory devices
Disturbed body image related to physical and
psychological changes and dependency
imposed by chronic illness
• Ineffective coping related to actual or
perceived lifestyle or role changes