3. Duodenal ulcer
Most common
Highly viscous mucous
Chief cells or
Peptic cells
HCl PH=1-3.5
Secret PH=1-3.5 Pepsin
(Active)
Help in
Protein
Breakdown
Pepsinogen
(Inactive)
STOMACH
Secret by gabbles cells
4.
5. Peptic ulcer
A peptic ulcer is an open sore in the upper digestive tract. There are two
types of peptic ulcers, a gastric ulcer, which forms in the lining of the
stomach, and a duodenal ulcer, which forms in the upper part of the
small intestine.
Reason of ulcer Imbalance between Protective factors/defensive
factors (Mucus and bicarbonate secretion) and aggregative factors
(HCl and pepsin)
Note-
Oxantic gland (made of Parital cell) Secrete HCl/H+
Acidic enviorment produce by gastric HCl Responsible for
Antimicrobial activity
6. Causes of peptic ulcer
the bacterium named Helicobacter pylori (H pylori,), camphylobacter
pyloric (C. pylori)
Decrease mucous secretion and bicarbonate secretion
Increase protein diet
Over intake of aspirin and non steroidal anti-inflammatory drugs
(NSAIDs),
Steroids (Preferably taken with antacid and with food to reduce the
chances of ulcer)
Skipping of diet
Over intake of coffee, tea
alcohol,
physical or emotional stress,
smoking, or
radiation therapy
7.
8. Sign and Symptoms
Some people may have no symptoms of an ulcer, but Main
symptoms include
Heart burn
Stomach Ulcer Blood in vomiting
Lower part bleeding- Black tarry stool Indication of
ulcer
Other symptom
abdominal pain,
nausea,
loss of appetite,
weight loss,
10. Anti Pyloric drugs
Used when cause of ulcer are C.pylori and H. pylori
Macrolide Antibiotic( Clarithromycin)-
MOA- Inhibit Protein synthesis
Beta lactum antibiotic (Amoxacillin)-
MOA- Inhibit cell wall formation
Nitroimidazole dvt. (Tinidazole, Ornidazole)
MOA- cidal in nature ( reduction of their Nitro group and
formation of metabolite that bind with DNA and interferes
its functions.
11. Antacid
MOA- Neutralize gastric HCl.
Ideal antacid should not increase gastric PH NMT 5 (otherwise chances of rebound
hyperacidity occurs)
Antacids should not be given with enteric coated tablet. Otherwise enteric coating will
dissolve in stomach. Becouse antacid increase the stomach PH
During acid neutralization foam formation occur
it will cause esophagus burn
so it is must to add antifoaming agent or dispersing agent (HLB value= 1-3)
these are the essensial component of antacid. Eg Polysiloxane (Simethicon ,
Dimethicon).
Formuation available in market-
Suspension
Chewable tablet
Note- NSAIDs should be taken with antacid It decrease the chances of ulcer.
ACID NUTRALIZATION CAPACITY IS USED TO DETERMINE THE STRENGTH OR
ACTIVITY OF ANTACID
13. Antacid
Non systemic antacid- Poorly absorbable
Al(HO)3 gel- Slowly acting
S/e- GIT motility- cause constipation
Mg(HO) 3 – solution strength7.5%w/v so called as MILK OF MAGNISIA (due
to its milky appearance.
S/e- Diarrhoea (laxative action, increase GIT motility)
CaCO3-
Most potent antacid
Fast acting antacid
S/e- Rebound acid secretion (Reflux acid secretion occur due to fast
neutralization HCl )
Note- Milk alkali syndrome occurs because previously Dr. prescribe
CaCO3 with milk- It increase blood ca++ level condition called as
Hypercalcimia (Symptoms- anxiety, decrease appetite etc)
14. Combination antacid therapy
Advantage combination of antacid
It decreases the individual dose of antacids---- So least side effects come
from individual antacid in combination.
Combination Advantage of combination
Eg. Al(HO)3 + Mg(HO) 3 Bowl movement least affected
Al(HO)3 + CaCO3 sustained action and less chances of rebound acidity
Ketoconazole + Antacid Decrease chances of ketoconazole
absorption
H2 blocker (Cimentidine- antiulcer)+
Antacid
Decrease the absorption of cimentidine
Anti TB ( Isoniazide) + Al(HO) 3 gel Decrease the absorption of Isoniazide
Most common Drug interactions
18. Anticholinergic drugs-
MOA-Inhibit acetyl choline action on muscarinic receptor- decrease
HCl secretion
Eg. Piperazine
S/e- Decrease salivation
Dryness of mouth, eye, skin
Constipation and other anti cholinergic s/e may come
H2 Blocker
MOA- Inhibit the Hitamine action on H2 Receptor - decrease HCl secretion
Cimentidine-
Use- Use as Pre anasthetic medication to decrease gastric secretion
and chances of regurgitation
S/e- 1. Decrease sperm count temporally (by inhibiting action of
dihydrotestostrone)
Metabolism
Testosterone
(Inactive)Note
Dihydrotestosterone
(Active)
19. It displace dihydrotestosterone from their binding site and
show Anti androgenic Activity (Decrease sperm counts)
2. Gynecomestiea (Increase prolectine secretion- increase milk secretion)
3. Loss of libidio
It inhibits cytochrom (Cyto P-450) group of enzyme in liver
inhibit metabolism of few drugs
D/I-
Increse the duration of action some co administered drugseg. Warfarin,
theophyline
Prostaglandins Analogue/ PGs derivatives-
PGE1 Analogue- Misoprostel, Rioprostil
PGE2 Analogue- Enprostil
MOA-1. Increase mucous and bicarbonate secretion
2. Show cyto protective action by Increasing mucosal blood supply
3 Increase healing by Increase blood supply
4. decrease HCl secretion
20. S/e-
Contraction in Intestinal smooth muscles- Abdominal cramps- Diarrohea
Contraction in Uterus & Uterine tube smooth muscles- Backache in females (C/I
in pregnancy) etc
Proton pump inhibitors-
MOA Inactive at neutral PH
Rearrangement into cationic
form(Sulphenic acid & Sulphenamide)
Covalently bind with –SH group of
proton pump
Inactive Proton pump
permanently
Decrease HCl secretion
D/I
PH <5
Inhibit the oxidation of some drugs eg. Warfarin, Diazepam
21. Ulcer protective drugs
Coat ulcer base
Eg- Sucralfate, Colloidal bismuth subcitrate(CBS)
Sucralfate
Chemically – it is Al salt of sulfated sucrose
S/E- Constipation due Aluminum
Hypophosphatemea
MOA
Assume gel like consistency at PH <4
by cross linking of its molecules
Coat ulcer base & also ppt
surface protin
D/I
Tetracycline + Sucralfate
Form complex with aluminum
Decrease the absorption of
tetracycline
22. Colloidal bismuth subcitrate(CBS)
MOA- 1. Foam complex with glycoprotin coat ulcer base
2. Increase PGE2 synthesis Increase mucosal blood supply
Increase healing of ulcer
3. Kill the bacteria which are responsible for ulcer
S/e- Osteodystrophy etc
Ulcer healing drugs
These drugs act by increasing thick mucous secretion by goblet cells
stimulate goblet cellsMOA-
Increase thick
mucous secretion
Increase life spam of
gastric mucosal cell
Eg.Carbenoxolane sodium
Deglycyrrhinized liquorice