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Current Trend in Management of Amblyopia. Latest as well as old methods of amblyopia management which include active and passive therapies. Amblyopia Therapy/ Amblyopia Treatment
What would be the perfect amblyopia therapy?
Effective
Good compliance
Acceptable to pts. and parent
Quick
Safe
Easy to administer
Cost effective
Well maintained
..............
Summary
Amblyopia occurs due to abnormal visual experience early in life
Proper optical correction alone is necessary for short period of time (6-8 weeks)
before initiation of other therapy
Part time occlusion of better eye is mainstay of treatment since 18th century to till
now
For severe and moderate amblyopia, 6 hrs and 2 hrs of patching is advised
respectively
Atropine is also used in children with poor compliance
Trial of patching can be given in patients as old as 17 yrs
Perceptual learning and pharmacological manipulation have shown areas of
amblyopia treatment beyond the critical period of visual development
Binocular stimulation, software based treatments and other methods do not have
promising result to replace the patching therapy till date
Most of the active therapy methods have good results when used together with
patching therapy
2. AMBLYOPIA
Old Definition: Reduction in visual form perception without
any structural deficits of the visual system, not correctable by
optical means
Current Definition: A unilateral or bilateral decrease of visual
acuity caused by pattern vision deprivation or abnormal
binocular interaction for which no obvious causes can be
detected by physical examination of the eye and cannot be
corrected by optical or surgical means but in appropriate
cases is reversible by therapeutic measures
Difference of > 2 lines between two eyes
< 6/9 VA
3. Amblyopia originated from Greek word:
Amblyos - dullness / blunt, Ops – vision
Condition in which the observer sees nothing & patient
very little
Prevalence
o Globally 1-5% (WHO 2015)
o In Nepal around 0.9 to 1.8%
o 4 times more frequent in premature children
o 6 times more frequent in children with delayed mile stones
o Smoking and use of drugs and alcohol during pregnancy
have been associated with risk of amblyopia
6. Prognostic Factors in Amblyopia
Positive factor Negative factor
functional organic
Central fixation Eccentric fixation
Random dot stereopsis No random dot stereopsis
Short duration Long duration
Young patient, motivated Older patient, un-motivated
9. IMPORTANCE OF TREATMENT
If left untreated, amblyopia produces a range of
functional deficits
Binocular function is also compromised
The presence of amblyopia (or its treatment) impact on
educational attainment, future career opportunities, self-
esteem & quality of life
The studies reveal the practical and emotional impact of
amblyopia and provide additional evidence in support of
the need to develop effective treatment
10. Goal of Treatment
To restore and improve visual acuity by two strategies:
I. Present clear retinal image to the amblyopic eye
o Eliminate causes of visual deprivation
o Correcting visually significant refractive errors
II. Make the child use the amblyopic eye
Recommended treatment should be based on
o Pt.’s age, VA, compliance with previous treatment &
physical, social and psychological status
11. What would be the perfect amblyopia
therapy?
Effective
Good compliance
Acceptable to pts. and parent
Quick
Safe
Easy to administer
Cost effective
Well maintained
12. Choices of Treatment
The choices of treatment of amblyopia are used
alone or in combination to achieve goal of
treatment
1. Passive Therapy
The patient experiences a change in visual
stimulation without any conscious effort
i. Proper refractive correction
ii. Occlusion
iii. Penalization
13. 2. Active Therapy
It is designed to improve visual performance by the
patient’s
conscious involvement in a sequence of a specific,
controlled
visual task that provide feedback
i. Pleoptics
ii. Near activities
iii. Active stimulation therapy using CAM vision
stimulator
iv. Syntonic phototherapy
v. Role of perceptual learning
vi. Binocular stimulation
vii. Software-based active treatments
viii. Exposure to dark
15. Proper Refractive Correction
Purpose
To provide sharp images and providing optimal
environment for amblyopia therapy
Give pt. proper optical correction alone
- Short period of time (6-8 weeks) before initiation of
other therapy
- In case of refractive amblyopia, a progressive improvement
in
acuity for up to 16 - 22 weeks has been shown in some pts.
after refractive correction (Stewart C. et al 2004)
17. REFRACTIVE ERROR CORRECTION
Improves VA in 25-33% of patients with anisometropic
amblyopia and also in strabismic amblyopia
ATS-5 (PEDIG) 2006 concluded that amblyopia improved
with optical correction in 77% and resolved in 27%
Chen et al (AJO 2007) concluded that amblyopia improved
with optical correction in 93% and resolved in 45%
Penalisation and occlusion is required only if the VA doesn’t
improve with glasses for 4 months
18. Occlusion Therapy
The most powerful and effective means of treating
amblyopia
Mainstay of treatment since 18th century to till now
Highly effective until 8 years of age
New studies have shown improvements upto 24 yrs of age
Cover good eye to stimulate amblyopic eye
Success rate 30-92%
19. o When fixation is central: simple & effective
o When fixation is eccentric: <7yrs central fixation recover
o Older the child harder to regain central fixation
Mode of Action
Prevent fixating eye taking part in act of vision and
removes inhibitory stimulus that arises from stimulation
from fixating eye (non-amblyopic eye)
21. Total VS Partial Occlusion
Total Partial
•All light is prevented from
entering eye
•Employed in amblyopic
eyes
with acuity less than 6/24
•Occlusion using elastoplast,
gauze pad, tape, doynes
rubber occluder
•Does not cut off the total
light
entering eye
•Degrades the vision of
normal
eye such that amblyopic eye
gets better vision and
preference
•Occlusion using cellophane,
transparent nail polish, or a
higher plus lens
22. Conventional VS Inverse
Conventional Inverse
•Occlusion of sound eye •Occlusion of amblyopic
eye so that eccentric
fixation becomes less
fixed
Full Time VS Part Time
Full time Part time
Removed only while going to
bed at night
Short time each day during
close work or watching
television
Choice of initial Rx In relapses after Rx and also
for maintenance
23. Patches
Micropore tape with soft tissue paper
Spectacle patch / frost glass
Doyne’s occluder Opaque Contact Lens
24. How to go about Occlusion?
Motivation of child and parents
Active vision exercises by amblyopic while non-
amblyopic eye is occluded
Occlusion is continued till amblyopic eye has
developed equal vision and equal preference of
fixation
May take 3-6 months
If there is no improvement, then treatment is stopped
Maintenance treatment is continued at least up to 9
yrs of age with part time occlusion and exercises
25. Follow up-depending on age, severity of amblyopia and
compliance-to look for VA, fixation pattern and
occlusion amblyopia
When to stop occlusion
- VA equals in both eyes
- Alternation of fixation (Repka 2008)
When VA is stable patching may be decreased slowly
Because amblyopia recurs in large no. of pts.
maintenance therapy or tapering of therapy should be
strongly considered
27. Prognostic considerations
Younger the age better the prognosis
Type of amblyopia myopic anisometropia>
hyperopic anisometropia> strabismic amblyopia>
stimulus deprivation
Pre-treatment VA
Type of occlusion
Type of fixation
Near exercises
Pt. compliance and parent education
Presence of astigmatism
Previous treatment
Refractive correction
30. Penalization
Therapeutic technique performed by optically
defocusing the eye with better vision by using
cycloplegia or altering the eye glass lens
Indications
o No compliance for occlusion
o Mild degrees of amblyopia
o Maintainence after occlusion
o Anisometropic amblyopia
31. Advantages: Cheap, better compliance
Disadvantages: Side effects of drugs
- Risk of occlusion amblyopia
- Systemic absorption
Unless penalisation decreases the VA of dominant eye
below the amblyopic eye this form of treatment is not
adviced
32. Methods of penalisation
a. Near penalization: fixing eye is atropinized & fully
corrected for distance, amblyopic eye is overcorrected
with +2.00 to +3.00 D
b. Distance penalization: fixing eye is atropinized &
overcorrected, amblyopic eye is fully corrected
c. Total: fixing eye is atropinized & undercorrected by
4.00 to 5.00 D, amblyopic eye is fully corrected
33. Summary of the PEDIG studies
Short
title
Ages
(Yrs)
Baseline
amblyo
pic eye
acuity
Primary
outcome
measure
Initial
treatment
prescribed
Results
(Impro
vemen
t)
Primary conclusion
ATS 1
(35)
3 to
<7
20/40-
20/100
Lines
improveme
nt after 26
weeks
Daily
atropine
At least 6
hrs daily
patching
2.8
lines
3.2
lines
Atropine and patching
are equally effective as
primary treatment for
moderate amblyopia
ATS
2A
(37)
3 to
<7
20/100-
20/400
Lines
improveme
nt after 17
weeks
6 hrs daily
patching
Full time
patching
4.8
lines
4.7
lines
6 hrs daily patching
produces improvement
similar to full time
patching for severe
amblyopia
ATS
2B
(36)
3 to
<7
20/40-
20/80
Lines
improveme
nt after 17
weeks
2 hrs daily
patching
6 hrs daily
patching
2.4
lines
2.4
lines
2 or 6 hrs of prescribed
daily patching produce
similar improvement for
moderate amblyopia
34. Summary of the PEDIG studies
Short
title
Ages
(Yrs)
Baseline
amblyo
pic eye
acuity
Primary
outcome
measure
Initial
treatment
prescribed
Results
(Improvement)
Primary conclusion
ATS3
(39)
7 to
<18
20/40-
20/400
Proportion
of
responders
(improveme
nt >2 lines)
after 24
weeks
2-6 hrs daily
patching (+
atropine if <12
yrs)
Spectacles
alone if
needed
Response rates:
Age≤12 yrs:
53%
Age≥13 yrs:
25%
Age≤12yrs: 25%
Age≥13 yrs:
23%
ATS 4
(34)
3 to
<7
20/40-
20/80
Lines
improvemen
t after 17
weeks
Weekend
atropine
Daily atropine
2.3 lines
2.3 lines
Weekend and daily atropine
produce similar improvement
for moderate amblyopia
ATS 5
(38)
3 to
<8
20/40-
20/400
Lines
improvemen
t after 5
weeks
2 hrs daily
patching
Spectacles
alone if
needed
1.1 lines
0.5 lines
After a period of spectacle
wear, 2 hrs daily patching is
superior to continuing
spectacles alone
35. Practical Implications of the PEDIG studies
Children < 7 yrs and VA between 6/12 to 6/24
- 2 hrs and 6 hrs patching - same effect
Children < 7 yrs and VA 6/30 - 6/120
- 6 hrs and full time patching - same effect
Children < 7 yrs and VA 6/12 - 6/30
- Daily atropine produces similar effect as 6 hrs patching
36. Practical Implications of the PEDIG studies
Children 7 to 18 yrs and VA 6/12 to 6/120
- 2 - 6 hrs patching leads to at least 2 lines
improvement
(if no previous treatment) but
- the compliance rate is poor in age >13 yrs
Children < 8 yrs and VA 6/12 - 6/120
- Patching 2 hrs is better than spectacles alone
38. Pleoptics: Gr. meaning full vision
Used for active stimulation of the fovea to overcome
eccentric fixation and improves the visual acuity
In this technique
- the peripheral retina is dazzled with an intense light
protecting
foveal area
- after the light source is turned off, the fovea functions
better
as the surrounding retinal area is in a state of hypofunction
- this can be followed by direct stimulation of fovea
by pleoptophore (Bangerter’s method)
or indirectly by producing after image (Cupper’s method)
39. Demerits
The technique is complex and requires an absolute co-
operation of the pt. and intelligence to appreciate after-
images
Daily sitting for a longer period of time is required
Since occlusion of the dominant eye is a very successful
simple and inexpensive method of treating eccentric fixation,
so the use of pleoptics methods is abandoned
Only indication is co-operative and intelligent child older than
6yrs having eccentric fixation
40. Pleoptics VS Occlusion of sound eye
Visual acuity outcomes in children who have had
conventional occlusion are found to be better than in
those who have gone through pleoptic treatment (Verlee
DL, Iacobucci 1967)
Visual acuity improvements are significantly greater in
the direct occlusion group than in the group
undergoing pleoptic therapy and inverse occlusion
(Veronneau T.S. et al 1974)
42. Method
Non amblyopic eye is occluded
Amblyopic eye is stimulated for 7 mins by slowly rotating (at
about 1 revolution per min) high contrast square wave
grating of different spatial frequencies
The treatment is carried out once in a week for 3 to 4 weeks
Advantages over the conventional occlusion therapy
o The sound eye remains open between the weekly treatment
sessions
43. Principle
Assumption that rotating grating provides specific stimulation
for cortical neurons
Present status of CAM vision stimulator
This technique is not as effective as conventional occlusion
therapy
So it has failed to replace time tested conventional occlusion
therapy for the treatment of amblyopia
Some workers use this technique as supplementary to
occlusion therapy in co-operative pts. with supportive
who can carry out the treatment at home
44. Recently a new treatment has been described based on a
similar principle, namely, the use of grating stimuli to activate
certain cortical cells (Angelika Shanshinova et al, 2008)
The treatment is computer-based and is intended to
supplement occlusion treatment, particularly in patients
beyond childhood
The treatment comprises a computer game viewed on a
monitor against the background of a low spatial frequency
drifting sine wave grating
45. The stimulus is a drifting sinusoidal grating of a spatial
frequency of 0.3 cyc/deg and a temporal frequency of 1
cyc/sec, reciprocally coordinated with each other to a drift of
0.33 deg/sec
Based on the idea that stimulation of motion-sensitive cells
might help to improve function of form-sensitive cells by
synchronisation of responses
Efficacy of treatment is higher for the computer based
method combined with occlusion than for occlusion only
47. Syntonics is the branch of ocular science dealing with the
application of selected visible light frequencies through the
eyes
For the purposes of treatment, syntonic optometrists define
four syndromes as follows: acute, chronic, emotional fatigue
and lazy eye
In lazy eye syndrome, amblyopia, strabismus, vergence
anomalies, suppression, ARC or visual field constrictions are
treated using red/orange filters
48. It is based on work by Spitler, in which 2,791 of 3,067
individuals responded positively to syntonic phototherapy
However, there is no published studies on the
effectiveness of this technique in amblyopia therapy
In the absence of studies providing good quality evidence
that amblyopic patients will be helped by syntonic
phototherapy, there seems to be no basis for prescribing
this treatment
Wallace LB. The theory and practice of syntonic phototherapy 2009
Spitler HR. The Syntonic Principle. Pennsylvania: Science Press Printing
Company, 1941.
50. Perceptual Learning
Any relatively permanent and consistent change in the
perception of stimulus array following practice or
experience with this array- Gibson (1963)
No. of studies suggest that perceptual learning (PL) may
provide an important new method for treating amblyopia
Principle
PL is reported to operate via a reduction of internal neural
noise and/ or through more efficient use of stimulus
information by returning weighting of the information
51. PL employs repeatedly practicing a visual discrimination
task, e.g: positional acuity, contrast sensitivity,
stereo-acuity, etc
Recommended period for PL: 2hrs/ day, 5 days/ week, for
a period of 9 months
Significant improvements found in VA and CS (Chen P. et al
2008, Huang C. et al 2006)
Role of PL is still controversial, but utility is reported in
adult amblyopes
52. Video Game Play & Brain Plasticity
The intense sensory-motor interactions are immersed
video-game play
This might push brain functions to the limit
Enables the amblyopic visual system to learn, on the fly,
to recalibrate and adjust, providing the basis for
functional plasticity
53. Video Game Play & Brain Plasticity
Game playing requires the allocation of spatial
detection, and localization of low contrast, fast moving
targets, and aiming
Video games may include several essential elements for
active vision training to boost visual performance
According to C. S. Green and co workers (2003) action
video game modifies visual selective attention
Thus, it could potentially be useful in improving
amblyopic vision
54. Video-Game Play Induces Plasticity in the Visual
System of Adults with Amblyopia
(Roger W. Li1 et al, August 30 2011)
o 10 amblyopic adults: Action Video Game, 40 hrs,
2hrs/day
o 3 amblyopic adult: Non-action Video Game, 40 hrs, 2
hrs/ day
o Non-amblyopic eye: Occlusion
o Control Group 7 adults: Only patching
Action Game: Medal of Honor: Pacific AssaultNon-Action Game: SimCity Societies
55.
56.
57.
58. PL is an area with clear potential for treating amblyopia
Significant improvements in vision can result from training
periods that are relatively short using tasks that are relatively
engaging, compared to conventional occlusion
It is important to be aware that the way in which these
improvements arise is not yet fully understood
Further research is needed before optimal training strategies
can be devised and before the way in which those strategies
modify visual function can be fully understood
60. During occlusion therapy, the non-amblyopic eye is
occluded i.e. binocular vision is not encouraged during
these periods
It has been recognized that binocular stimulation may be
important in the treatment of amblyopia
Animal research (Mitchell DE 2008) and recent studies (Baker
DH et al 2007, Mansauri et al 2007) indicate that binocular
stimulation encourages binocular cortical connections
during recovery from deprivation amblyopia
Offers support for binocular stimulation when treating
amblyopia
61. One existing approach to treating amblyopia that allows
binocular stimulation is the use of Bangerter foils (Baker and
colleagues 2007)
Another long-standing and widely used approach is atropine
penalization
In both cases, the image at the fovea of the non-amblyopic
eye is degraded (for near vision in the case of atropine), while
input to the amblyopic eye is not affected
In these therapeutic scenarios, vision is binocular in the sense
that both eyes receive light stimulation and peripheral
resolution is not significantly impeded (Wang YZ et.al 1997)
62. Comparisons between occlusion and atropine (LI T et al 2009)
or between occlusion and Bangerter foils (PEDIG 2010) as
treatments for amblyopia show no significant difference in
outcome
Suggests that this type of binocular stimulation does not
offer significant advantages over the combination of
binocular and monocular vision allowed by periods of
occlusion
63. The ‘monocular fixation in a binocular field’ (MFBF)
technique
Introduced with the intention of training the amblyopic visual
system to integrate information from both eyes (Cohen AH.
Monocular fixation in a binocular field. J Am Optom Assoc 1981)
This technique involves the presentation of peripheral stimuli
to both eyes, while only the amblyopic eye is stimulated at
the fovea
64. The ‘monocular fixation in a binocular field’ (MFBF)
technique
Applied in a range of paper-based formats.
E.g, pt. may be instructed to complete tasks such as
crossword
puzzles or placing dots in the ‘o’ letters in a text, using a
pen and wearing red-green glasses, with the red lens in
of the non-amblyopic eye (Wick B. et al 1992)
65. I-BiT™ Interactive Binocular Treatment for
Amblyopia
Concept
Present separate images to each eye
Dynamic visual scene
Preferentially stimulating amblyopic eye
Patient motivation
Interactive games and videos
Encourage patient compliance
Shutter Glasses Technology
o Shutter glasses
o High definition screens
o Faster processing speeds
66. Adaptations for use with the I-BiT system
Shutter glasses with I-BiT software is to change the ratio
of information presented to each eye in order to
stimulate one eye more than the other
This creates a 2D view rather than the intended 3D
stereoscopic view
DVD Player
o Border with controls common
to both eyes
o Only amblyopic eye sees the
DVD
NUX Game
67. Evidence
Six children treated with prototype and gained 2 lines of
vision (Waddingham et al Eye 2006)
10 treated with I-BiT and improvement of 0.189 logMAR,
almost 2 lines (Herbison et al Eye 2013)
Other groups: e.g. Hess’s group with the game Tetris in
adults (required a minimum of 6 hrs play before any effect is
discernible)
68. Fig: Visual acuity in LogMAR units for all patients
from baseline to week 10.
Herbison et al Eye 2013
70. The AmbP iNet program for the treatment of Amblyopia
Marketed by Home Therapy Solutions
System features 12 treatment programs, 6 of which are
randomly assigned for completion by the patient each
5 days per week
Involve activities like ‘letter jump’, among others
The treatment involves visual search of certain target
71. The AmbP iNet program for the treatment of
Amblyopia
Treatment system is designed to improve hand eye co-
ordination, VA, crowding effect and visual memory
No published reports of clinical trials of this method, so it
is not possible to know whether the design is effective as
part of a treatment for amblyopia
Thus, controlled trials of this treatment are needed
(Cooper J. et al 2007)
72. Not a "lazy" eye, but a "lazy" brain
Amblyopia therapy is:
o Completed at home on a computer
o 2-3 times per week
o Each of the 40 sessions takes an average of 40 minutes
Precise visual tasks consisting of patterned images with
subtle differences in orientation, size and contrast
Through repetitive practice the brain is trained to be
efficient and to improve visual processing
Specialized RevitalVision™ algorithms analyze
73. Binocular iPad Game VS Part-Time Patching
2 studies (PEDIG 2016), (K.R. Kelly et al 2016) were done to
compare VA improvement in children with amblyopia treated
with a binocular iPad game vs part-time patching
Effect of a Binocular iPad Game vs Part-time Patching in Children Aged 5 to 12 Years
With Amblyopia A: Randomized Clinical Trial;Jonathan M. Holmes et; for the Pediatric
Eye Disease Investigator Group, JAMA Ophthalmology, November-3, 2016
Binocular iPad Game vs Patching for Treatment of Amblyopia in Children:A
Randomized Clinical Trial; Krista R. Kelly, PhD; Reed M. Jost, MS; Lori Dao, MD;
Cynthia L. Beauchamp, MD; Joel N. Leffler, MD; Eileen E. Birch, PhD, JAMA
Ophthalmology, December 2016
74. Fig: Visual Acuity (VA) in Amblyopic Eyes From Baseline to 16Weeks
(PEDIG 2016)
VA improves with binocular game play and with
patching, particularly in younger children (age 5 to <7
years)
VA improvement with this particular binocular iPad
treatment is not as good as with 2 hrs of prescribed daily
75. • High-contrast red elements (miners and fireball) are seen by the
amblyopic eye
• Low-contrast blue elements (gold and cart) are seen by the fellow
eye
• Gray elements (rocks and ground) are seen by both eyes
• Both eyes must see the game for successful play
Fig: Dig Rush Game
(K.R. Kelly et al 2016)
76. Fig: Best-Corrected Visual Acuity (BCVA) at Baseline, the 2-Week Visit, and the 4-
Week Visit
(K.R. Kelly et al 2016)
Binocular iPad game is a successful treatment for childhood
amblyopia and is more effective than patching at the 2-week
visit
78. Dark exposure promotes recovery from amblyopia
It is based on Duffy and Mitchell (2013, current
biology) animal (kittens) experiments
79. Three key parameters will have to be established first
o What is the minimum period of dark exposure needed to
trigger restoration of visual cortex plasticity?
o What is the age dependence of this effect?
o How absolute does the darkness have to be?
The answers to these questions will ultimately determine
the utility of this approach to treating amblyopia
81. Levodopa & citicoline are the most extensively studied
drugs
Plasticity of visual system during the sensitive period is
dependent on input from non-adrenergic neurons and thus
can be subjected to pharmacological manipulation
Precursor for the catecholamine dopamine, a
neurotransmitter, known to influence visual system at retina
and cortical level
It either extends or reactivates the visual system’s sensitive
period of neural plasticity
Catecholamine based medical treatment has been
demonstrated to improve vision in amblyopic eyes.
82. Leguire and co-workers (1993) found that 1 hr after
levodopa ingestion,VA, CS and PVEP temporarily improve
but starts to decrease 5 hrs after drug ingestion
They concluded that combination of levodopa and
occlusion improves visual function more than levodopa-
carbidopa alone in amblyopic children
Dadeya et al (2009) concluded that there is more than two
lines improvement in visual acuity, especially in children
younger than eight years of age
83. Citicoline (cytidine 5’-diphosphocholine) used in a
dose of 1,000 mg I.M. for 15 days to patients aged 9–
37 yrs causes a temporary improvement in visual
acuity without any side effects (Campos et al 1995)
Use of oral levodopa while continuing to patch 2 hrs
daily does not produce a clinically or statistically
meaningful improvement in VA compared with
patching (PEDIG 2015)
84. Advantages
o Augments conventional occlusion
o Speeds up recovery of visual functions
o Improves compliance
o Possibility for adult amblyopes
o Reduces cost and duration of treatment
86. Active vision therapies for amblyopia involve paper-based
near activities such as reading, writing and word puzzles
Von Noorden and associates (1970) found that minimal (1 hr
per day) occlusion combined with these exercises is
beneficial in the treatment of amblyopia for older children
The latter studies (PEDIG 2005, 2008) provide high level
evidence that the use of near activities is not helpful in the
treatment of amblyopia
In the absence of reliable evidence to the contrary, there is
not yet a sound basis for prescribing these tasks for pts.
undergoing treatment for amblyopia
87. Summary
Amblyopia occurs due to abnormal visual experience
early in life
Proper optical correction alone is necessary for short
period of time (6-8 weeks) before initiation of other
therapy
Part time occlusion of better eye is mainstay of treatment
since 18th century to till now
For severe and moderate amblyopia, 6 hrs and 2 hrs of
patching is advised respectively
Atropine is also used in children with poor compliance
Trial of patching can be given in patients as old as 17 yrs
88. Perceptual learning and pharmacological manipulation
have shown areas of amblyopia treatment beyond the
critical period of visual development
Binocular stimulation, software based treatments and
other methods do not have promising result to replace the
patching therapy till date
Most of the active therapy methods have good results
when used together with patching therapy
Summary
89. Amblyopia is still an unsolved problem, the best
modality of treatment is still to be explored in
future
Thankyou
Notas del editor
In bilateral amblyopia…
In unilateral amblyopia..
Amblyopia is a visual impairment secondary to abnormal visual experience (e.g., strabismus, anisometropia, form deprivation) during early childhood.
Prognostic factors play important role in management of amblyopia. Positive factors mean easier to restore vision whereas negative factors mean harder or almost impossible to restore vision
This includes older as well as new treatment methods which are currently in use
Removal of obstacles in visual pathway which includes Strabismus surgery…..pediatric cataract surgery..ptosis surgery
Pediatric eye disease investigator group
When used in combination with other active therapies
Active vision exercises by amblyopic eye like dotting O’s and encircling E’s in a newspaper, joining dots, reading comics and story books
PEDIG- Pediatric eye disease investigator group
ATS- Amblyopia Treatment Study
Action video game
(B) Non-action video game
Control experiment.
(D) Summary of acuity data.
10 adults: action game, 3 amblyopes in non action game
Binocular stimulation in thetreatment of amblyopia
Binocular stimulation in thetreatment of amblyopia
Interactive Binocular Treatment
Interactive Binocular Treatment
Interactive Binocular Treatment
It is the software based active treatment which works on the principle of perceptual learning
Tetris game with falling blocks
385 pts. Involved, (190 participants; binocular group, 1 hr game play)), (195 participants; patching group, 2 hr patching), 16 weeks
Only 14 pts. Involved, only for 2 weeks
- Only 14 pts. Involved, only for 2 weeks
-385 pts. Involved, (190 participants; binocular group, 1 hr game play)), (195 participants; patching group, 2 hr patching), 16 weeks
Amblyopia was induced by monocular lid suture in kittens aged 30 days. After re-opening the eye seven days later, visual acuity was assessed daily for both eyes in an orientation discrimination task using the jumping stand (A). Acuity in the non-deprived eye (dotted curve in B) increased steadily to reach adult levels by 90 days of age. The animal was initially blind in the deprived eye (solid line in B); vision improved gradually but reached a plateau by 90 days of age at roughly half of normal acuity. After 10 days in a dark-room, acuity in the amblyopic eye suddenly increased within a few days to that of the fellow eye.