GKA deel 1 college 15

The hallmarks of cancer Hanahan & Weinberg, Cell 100, 2000, 57-70 GK 2009

The hallmarks of cancer Hanahan & Weinberg, Cell 100, 2000, 57-70 GK 2009 Mantovani Nature 457, 36-37(2009)

Infectious causes of cancer and their detection Dalton-Griffin and Kellam, J of Biology 2009, 8:67doi:10.1186/jbiol168 GK 2009 Figure 1.

The hallmarks of cancer Hanahan & Weinberg, Cell 100, 2000, 57-70 GK 2009 Tumour development is an evolutionary process

The hallmarks of cancer Hanahan & Weinberg, Cell 100, 2000, 57-70 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GK 2009 Deranged processes in tumor cell: Tumour development is an evolutionary process

Tumor morphology Hanahan & Weinberg GK 2009

Blueprint of a cell Hanahan & Weinberg GK 2009 3 3 2 1 4 5 2 Red: identified mutations in cancer cells

Mutations in glioblastomas The Cancer Genome Atlas Research Network Nature 455, (2008) 1061-1068 Comprehensive genomic characterization defines human glioblastoma genes and core pathways GK 2009 Inserted 17-11-2008

Mutations in lung adenocarcinomas Ding et al., Nature 455 (2008)1069-1075 GK 2009 Inserted 17-11-2008

Growth factor-independence Hanahan & Weinberg ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GK 2009

Role of integrins From: Yamada & Even-Ram, Nature Cell Biology 4, 2002, E75-E76 GK 2009 Integrins are required for survival For adults only

Role of integrins From: Yamada & Even-Ram, Nature Cell Biology 4, 2002, E75-E76 GK 2009 Integrins are required for survival

Anti-proliferation Hanahan & Weinberg ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GK 2009

Properties of apoptosis Hanahan & Weinberg ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GK 2009

Escape from apoptosis Hanahan & Weinberg, Cell 100, 2000, 57-70 ,[object Object],[object Object],[object Object],[object Object],GK 2009

Unlimited cell division Hanahan & Weinberg ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GK 2009

Continuous angiogenesis Hanahan & Weinberg ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],GK 2009

Order of mutations Hanahan & Weinberg ,[object Object],[object Object],[object Object],GK 2009

CSC: the cancer stem cell Rosen and Jordan (2009) Science 324: 1670-1673 ,[object Object],[object Object],GK 2009 Inserted 2-12-2009

The end! GK 2009 Einde van 1 e helft van de cursus. Veel succes met het studeren… DNA repair

GKA deel 1 college 15

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