Best practices for neuroimaging.

1. Dr. Brian J. Spiering
email: bspiering@gmail.com
website: brianspiering.com
5 fMRI Research Wins

2. 5 fMRI Research Wins
1) Have a Theory
2) Build a Behavioral Base
3) Design, Redesign
4) Create an Analysis Hitlist
5) Make Writing Fast (& Fun)

3. 1) Have a Theory
A theory can be proved by experiment;
but no path leads from experiment
to the birth of a theory.
- Manfred Eigen

4. - Begin with the neuroanatomy
- Account for previous results
- Make specific, falsifiable predictions
1) Have a Theory

5. Ashby et al. (1998)
Ashby, Paul, & Maddox (2011)
COVIS
(Competition BetweenVerbal and Implicit Systems)

6. SPEED
(Subcortical Pathways Enable Expertise Development)
Ashby, Ennis, & Spiering (2007)

9. Pessoa & Adolphs (2011)

10. Pessoa (2011)

11. Pessoa (2011)

12. 2) Build a Behavioral Base
All life is an experiment.
The more experiments you make the better.
- Ralph Waldo Emerson

13. 2) Build a Behavioral Base
- Understand the literature
- Pick the low hanging fruit
- Simplify, simplify, simplify

14. Category Learning Task

15. Category Learning Stimuli

16. Unstructured Categorization

17. Rule-Based Categorization

18. Information-Integration Categorization

19. Experiment 1 - Within

23. Experiment 1 - Within
Training Accuracy

24. Experiment 1 - Within
Transfer Accuracy

25. Experiment 2 - Between

26. Experiment 2 - Between
Training Accuracy

27. Experiment 2 - Between
Transfer Accuracy

28. 3) Design, Redesign
Design is not just what it looks like.
Design is how it works.
- Steve Jobs

29. 3) Design, Redesign
- Define project outcome
- Thrash Now
- Create a devil’s advocate

30. fMRI Methods

34. Results

35. Results

36. Results

37. ResultsResults

38. 4) Create an Analysis Hitlist
It's not the plan that is important,
it's the planning.
- Dr. Graeme Edwards

39. 4) Create an Analysis Hitlist
- Door wide open
- Think through all steps
- 2 week sprints

40. Expectancy violation in
cadence perception

41. Standard Ending

42. Deceptive Ending

43. Modulation Ending

44. Atonal Ending

45. Music-related Activations
Music > Silence Baseline

46. Ending-related Activations
All Ending > Music Baseline

47. Cortex Activation by Ending

48. Anatomical ROIs

49. Standard Ending - .01
Deceptive Ending - .02
Modulation Ending - .05
Atonal Ending - .99
Parametric Regressor

50. Basal Ganglia
Parametric Activation

51. Granger Causality Modeling

52. 5) Make Writing Fast (& Fun)
The faster I write the better my output.
If I’m going slow I’m in trouble.
It means I’m pushing the words
instead of being pulled by them.
-Raymond Chandler

53. Analysis Paper
Door Open Door Closed
Team Single Advocate
Compile Winnow

54. Smith,Ashby, Berg, Murphy, Spiering, Cook, & Grace, 2011

56. F. Greg Ashby Carol A. Seger
Erik J. Peterson
Dan Lopez-Paniagua
Kurt Braunlich
Anastasia Sares
Alexander Gonzalez
Catie Alpeter
Sarah Quraini
Collaborators