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Evaluating the National HIV/AIDS Strategy
         with Surveillance Data



                    H. Irene Hall, PhD, FACE
     Chief, HIV Incidence and Case Surveillance Branch

         2011 National HIV Prevention Conference
                     August 15, 2011



        National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
        Division of HIV/AIDS Prevention
Outline

   Outcome measures of the National HIV/AIDS
    Strategy
   Surveillance data collection
   Preliminary data
   Conclusion
National HIV/AIDS Strategy

   Reducing New HIV Infections
   Increasing Access to Care and Improving Health
    Outcomes for People Living with HIV
   Reducing HIV-Related Health Disparities
Reducing New HIV Infections

   Lower the annual number of new infections by 25
    percent
   Reduce the HIV transmission rate, which is a
    measure of annual transmissions in relation to the
    number of people living with HIV, by 30 percent
   Increase from 79 percent to 90 percent the
    percentage of people living with HIV who know
    their serostatus
Increasing Access to Care and
                 Improving Health

   Increase the proportion of newly diagnosed patients
    linked to clinical care within three months of their
    HIV diagnosis from 65 percent to 85 percent
   Increase the proportion of Ryan White HIV/AIDS
    Program clients who are in continuous care (at least
    2 visits for routine HIV medical care in 12 months at
    least 3 months apart) from 73 percent to 80 percent
     A benchmark for surveillance?
Reducing HIV-Related Health Disparities

   Increase the proportion of HIV diagnosed gay and
    bisexual men with undetectable viral load by 20
    percent
   Increase the proportion of HIV diagnosed Blacks
    with undetectable viral load by 20 percent
   Increase the proportion of HIV diagnosed Latinos
    with undetectable viral load by 20 percent
HIV Surveillance

           Measures of HIV morbidity and mortality

HIV Infection
           HIV diagnosis
           (1st positive
           confidential test) 1st   CD4 Count
                             1st Viral Load
                             Test                 1st CD4
                                                  Count <200
                             1st Drug             (IMM-AIDS)
                             Resistance test                        AIDS-OI
                                                                                    Death
                      Entry to care       Retention in care and viral suppression
HIV Case Surveillance Information Flow


 People with HIV




Sources of Reports
                                        Local Health Dept         Dissemination
                                                     HIV      Local Bulletins
Hospital Practitioners                             Report     CDC Semiannual Report
Private Practitioners                                         HIV Web Sites
                                                     2001
Public Clinics                                     Region X
                                                              Public Information Data Set
Laboratories                                                  Surveillance Slide Set
                           Active
                         Case Finding

                                        State Health Dept        CDC

                                           7,738              74,353
National HIV Surveillance

Data Year

2008: confidential, name-
based HIV reporting in all
states

2011: all states included in
estimates of HIV diagnoses
National HIV Incidence Surveillance



                WA
                                                CHI

                                                                 MA
                                                           NYS   CT
                                                MI
                                                                 NYC
SF
                          CO                   IN                NJPhil
           CA                                          VA        DC
                                                      NC
     LA              AZ                               SC
     Cty
                                          MS   AL
                               TX   LA

                                                      FL

                                    HOU
Areas with Laws and Regulations for
Reporting all CD4 and Viral Load Values

                                        VT

                                                      NH
                                                      MA
                                                      RI
                                                      CT
                                                      NJ
                                                      DE
                                                      MD
                                                      DC




                                             Laboratory reporting
                                             (laws and regulations)
                                                Not all values
                                               All values, specified
                                               All values, not
                                               specified
                 Puerto Rico
                 Virgin Islands, U.S.
National HIV/AIDS Strategy
                     Implementation Plan
   VA, CMS, HRSA, CDC, SAMHSA and NIH will jointly consider and issue
    a report of strategies to encourage providers to collect and report
    standardized viral load and CD4 data from infected individuals within
    populations at greatest risk for HIV infection.
      CDC will identify which States and localities collect CD4 and viral load data
      HRSA and CDC will convene a consultation with clinical providers and
       community-based organizations to develop recommendations for
       gathering and reporting necessary data to calculate community viral load
      CDC, in consultation with States, will provide technical assistance to
       localities, particularly those with a heavy disease burden, to collect
       necessary data to calculate community viral load
National HIV/AIDS Strategy
                 Implementation Plan
   CDC will release a report on suggestions for border states to help
    improve HIV surveillance and prevention interventions among
    migrant communities

   CDC will provide State health departments with greater
    concentrations of AAPI or AI/AN populations with recommendations
    on effective HIV surveillance activities for these small populations

   HHS OS will coordinate among HHS agencies to mine existing
    databases to explore associations between HIV infection and social
    determinants of health
PRELIMINARY DATA
HIV Incidence 2006-2009,
                                  United States

60,000

50,000
                                         56,000
                                     (49,100-69,200)
40,000          48,600                                            47,800                   48,100
            (42,400-54,700)                                   (41,800-53,800)          (42,200-54,000)
30,000

20,000

10,000

    0
                 2006                     2007                     2008                     2009

   Prejean (2011) Estimated HIV Incidence in the United States, 2006–2009. PLoS ONE 6(8): e17502.
   doi:10.1371/journal.pone.0017502
Estimated AIDS Diagnoses, Deaths, Persons Living with an AIDS
Diagnosis and Persons Living with HIV Infection (Diagnosed and
 Undiagnosed) Among Adults and Adolescents – United States,
                                                                                                                   1981 - 2008
                                 80                                                                                                                                                                                                       1,200
                                                     AIDS Diagnoses
                                                                                                                                                                                                                                          1,100
                                 70                  Deaths
                                                                                                                                                                                                                                          1,000
   No. of Diagnoses and Deaths




                                                     Living with an AIDS Diagnosis
                                 60                                                                                                                                                                                                       900
                                                     Living with HIV infection
                                                                                                                                                                                                                                          800
                                 50
            (thousands)




                                                                                                                                                                                                                                                  (thousands)
                                                                                                                                                                                                                                                  Prevalence
                                                                                                                                                                                                                                          700

                                 40                                                                                                                                                                                                       600

                                                                                                                                                                                                                                          500
                                 30
                                                                                                                                                                                                                                          400

                                 20                                                                                                                                                                                                       300

                                                                                                                                                                                                                                          200
                                 10
                                                                                                                                                                                                                                          100

                                  0                                                                                                                                                                                                       0
                                                           1984




                                                                                       1988




                                                                                                                          1993




                                                                                                                                                                                         2002
                                      1981
                                             1982
                                                    1983


                                                                  1985
                                                                         1986
                                                                                1987


                                                                                              1989
                                                                                                     1990
                                                                                                            1991
                                                                                                                   1992


                                                                                                                                 1994
                                                                                                                                        1995
                                                                                                                                               1996
                                                                                                                                                      1997
                                                                                                                                                             1998
                                                                                                                                                                    1999
                                                                                                                                                                           2000
                                                                                                                                                                                  2001


                                                                                                                                                                                                2003
                                                                                                                                                                                                       2004
                                                                                                                                                                                                              2005
                                                                                                                                                                                                                     2006
                                                                                                                                                                                                                            2007
                                                                                                                                                                                                                                   2008
                                                                                                                                  Year



  MMWR 2011;60:689-693.
Annual Transmission Rates per 100 Persons
        Living with HIV, 1977–2006




Holtgrave . Updated Annual HIV Transmission Rates in the United States, 1978-2006. JAIDS 2009;50(2):236-38.
Estimated Number of Adults and Adolescents Living with HIV
Infection (Diagnosed and Undiagnosed) and Percent Undiagnosed
                   – United States, 1985 - 2008
           1,200,000                                             No. living with undiagnosed HIV infection                                                                                       100.0

                                                                 No. living with diagnosed HIV infection
                                                                 Percent undiagnosed
           1,000,000
                                                                                                                                                                                                 80.0



            800,000

                                                                                                                                                                                                 60.0
  Number




                                                                                                                                                                                                         Percent
            600,000


                                                                                                                                                                                                 40.0

            400,000



                                                                                                                                                                                                 20.0
            200,000




                  0                                                                                                                                                                              0.0


                                                                                                                                                2002

                                                                                                                                                       2003

                                                                                                                                                              2004

                                                                                                                                                                     2005
                       1985

                              1986

                                     1987

                                            1988

                                                   1989

                                                          1990

                                                                   1991

                                                                          1992

                                                                                 1993

                                                                                        1994

                                                                                               1995

                                                                                                      1996

                                                                                                             1997

                                                                                                                    1998

                                                                                                                           1999

                                                                                                                                  2000

                                                                                                                                         2001




                                                                                                                                                                            2006

                                                                                                                                                                                   2007

                                                                                                                                                                                          2008
                                                                                                      Year
Linkage to Care and Continuous Care
   Data from 13 areas with mandatory laboratory
    reporting of HIV-related tests and reporting to
    national HIV surveillance
     82% of persons diagnosed in 2009 linked to care within 3
      months -- NHAS 85 percent
        Poster No. 083M. Mahle et al. Using HIV Surveillance-based Indicators to Monitor the National HIV/AIDS
        Strategy, 13 U.S. Jurisdictions



     Persons living with HIV in 2009 in continuous care – NHAS 80%
           Track B Session B04 . Hall et al. Retention in Care of HIV-Infected Adults and Adolescents in 13 U.S.
           Areas
Reducing HIV-Related Health Disparities
   Data from 13 areas with mandatory laboratory reporting of HIV-
    related tests and reporting to national HIV surveillance
   Persons living with HIV in 2009
   Viral suppression (≤400 copies/mL) among those in care, vs.
    NHAS undetectable viral load
         77% among MSM
         65% among blacks/African Americans
         74% among Hispanics/Latinos
          •       vs. 81% among whites
   NHAS – increase by 20 percent
    Poster No. 083M. Mahle et al. Using HIV Surveillance-based Indicators to Monitor the National HIV/AIDS
    Strategy, 13 U.S. Jurisdictions
Conclusion

   Of 9 outcome measures in the National HIV/AIDS
    Strategy, 8 can be measured with surveillance data

   However, there is a need to
     Support and strengthen HIV … surveillance activities: There
      is a need to support existing surveillance methods to
      identify populations at greatest risk that need to be targeted
      for HIV prevention services.
Thank you




The findings and conclusions in this report are those of the authors and do not necessarily represent the official position o f
the Centers for Disease Control and Prevention.




                      National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
                      Division of HIV/AIDS Prevention

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Evaluating the National HIV/AIDS Strategy with Surveillance Data

  • 1. Evaluating the National HIV/AIDS Strategy with Surveillance Data H. Irene Hall, PhD, FACE Chief, HIV Incidence and Case Surveillance Branch 2011 National HIV Prevention Conference August 15, 2011 National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Division of HIV/AIDS Prevention
  • 2. Outline  Outcome measures of the National HIV/AIDS Strategy  Surveillance data collection  Preliminary data  Conclusion
  • 3. National HIV/AIDS Strategy  Reducing New HIV Infections  Increasing Access to Care and Improving Health Outcomes for People Living with HIV  Reducing HIV-Related Health Disparities
  • 4. Reducing New HIV Infections  Lower the annual number of new infections by 25 percent  Reduce the HIV transmission rate, which is a measure of annual transmissions in relation to the number of people living with HIV, by 30 percent  Increase from 79 percent to 90 percent the percentage of people living with HIV who know their serostatus
  • 5. Increasing Access to Care and Improving Health  Increase the proportion of newly diagnosed patients linked to clinical care within three months of their HIV diagnosis from 65 percent to 85 percent  Increase the proportion of Ryan White HIV/AIDS Program clients who are in continuous care (at least 2 visits for routine HIV medical care in 12 months at least 3 months apart) from 73 percent to 80 percent  A benchmark for surveillance?
  • 6. Reducing HIV-Related Health Disparities  Increase the proportion of HIV diagnosed gay and bisexual men with undetectable viral load by 20 percent  Increase the proportion of HIV diagnosed Blacks with undetectable viral load by 20 percent  Increase the proportion of HIV diagnosed Latinos with undetectable viral load by 20 percent
  • 7. HIV Surveillance Measures of HIV morbidity and mortality HIV Infection HIV diagnosis (1st positive confidential test) 1st CD4 Count 1st Viral Load Test 1st CD4 Count <200 1st Drug (IMM-AIDS) Resistance test AIDS-OI Death Entry to care Retention in care and viral suppression
  • 8. HIV Case Surveillance Information Flow People with HIV Sources of Reports Local Health Dept Dissemination HIV Local Bulletins Hospital Practitioners Report CDC Semiannual Report Private Practitioners HIV Web Sites 2001 Public Clinics Region X Public Information Data Set Laboratories Surveillance Slide Set Active Case Finding State Health Dept CDC 7,738 74,353
  • 9. National HIV Surveillance Data Year 2008: confidential, name- based HIV reporting in all states 2011: all states included in estimates of HIV diagnoses
  • 10. National HIV Incidence Surveillance WA CHI MA NYS CT MI NYC SF CO IN NJPhil CA VA DC NC LA AZ SC Cty MS AL TX LA FL HOU
  • 11. Areas with Laws and Regulations for Reporting all CD4 and Viral Load Values VT NH MA RI CT NJ DE MD DC Laboratory reporting (laws and regulations) Not all values All values, specified All values, not specified Puerto Rico Virgin Islands, U.S.
  • 12. National HIV/AIDS Strategy Implementation Plan  VA, CMS, HRSA, CDC, SAMHSA and NIH will jointly consider and issue a report of strategies to encourage providers to collect and report standardized viral load and CD4 data from infected individuals within populations at greatest risk for HIV infection.  CDC will identify which States and localities collect CD4 and viral load data  HRSA and CDC will convene a consultation with clinical providers and community-based organizations to develop recommendations for gathering and reporting necessary data to calculate community viral load  CDC, in consultation with States, will provide technical assistance to localities, particularly those with a heavy disease burden, to collect necessary data to calculate community viral load
  • 13. National HIV/AIDS Strategy Implementation Plan  CDC will release a report on suggestions for border states to help improve HIV surveillance and prevention interventions among migrant communities  CDC will provide State health departments with greater concentrations of AAPI or AI/AN populations with recommendations on effective HIV surveillance activities for these small populations  HHS OS will coordinate among HHS agencies to mine existing databases to explore associations between HIV infection and social determinants of health
  • 15. HIV Incidence 2006-2009, United States 60,000 50,000 56,000 (49,100-69,200) 40,000 48,600 47,800 48,100 (42,400-54,700) (41,800-53,800) (42,200-54,000) 30,000 20,000 10,000 0 2006 2007 2008 2009 Prejean (2011) Estimated HIV Incidence in the United States, 2006–2009. PLoS ONE 6(8): e17502. doi:10.1371/journal.pone.0017502
  • 16. Estimated AIDS Diagnoses, Deaths, Persons Living with an AIDS Diagnosis and Persons Living with HIV Infection (Diagnosed and Undiagnosed) Among Adults and Adolescents – United States, 1981 - 2008 80 1,200 AIDS Diagnoses 1,100 70 Deaths 1,000 No. of Diagnoses and Deaths Living with an AIDS Diagnosis 60 900 Living with HIV infection 800 50 (thousands) (thousands) Prevalence 700 40 600 500 30 400 20 300 200 10 100 0 0 1984 1988 1993 2002 1981 1982 1983 1985 1986 1987 1989 1990 1991 1992 1994 1995 1996 1997 1998 1999 2000 2001 2003 2004 2005 2006 2007 2008 Year MMWR 2011;60:689-693.
  • 17. Annual Transmission Rates per 100 Persons Living with HIV, 1977–2006 Holtgrave . Updated Annual HIV Transmission Rates in the United States, 1978-2006. JAIDS 2009;50(2):236-38.
  • 18. Estimated Number of Adults and Adolescents Living with HIV Infection (Diagnosed and Undiagnosed) and Percent Undiagnosed – United States, 1985 - 2008 1,200,000 No. living with undiagnosed HIV infection 100.0 No. living with diagnosed HIV infection Percent undiagnosed 1,000,000 80.0 800,000 60.0 Number Percent 600,000 40.0 400,000 20.0 200,000 0 0.0 2002 2003 2004 2005 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2006 2007 2008 Year
  • 19. Linkage to Care and Continuous Care  Data from 13 areas with mandatory laboratory reporting of HIV-related tests and reporting to national HIV surveillance  82% of persons diagnosed in 2009 linked to care within 3 months -- NHAS 85 percent Poster No. 083M. Mahle et al. Using HIV Surveillance-based Indicators to Monitor the National HIV/AIDS Strategy, 13 U.S. Jurisdictions  Persons living with HIV in 2009 in continuous care – NHAS 80% Track B Session B04 . Hall et al. Retention in Care of HIV-Infected Adults and Adolescents in 13 U.S. Areas
  • 20. Reducing HIV-Related Health Disparities  Data from 13 areas with mandatory laboratory reporting of HIV- related tests and reporting to national HIV surveillance  Persons living with HIV in 2009  Viral suppression (≤400 copies/mL) among those in care, vs. NHAS undetectable viral load  77% among MSM  65% among blacks/African Americans  74% among Hispanics/Latinos • vs. 81% among whites  NHAS – increase by 20 percent Poster No. 083M. Mahle et al. Using HIV Surveillance-based Indicators to Monitor the National HIV/AIDS Strategy, 13 U.S. Jurisdictions
  • 21. Conclusion  Of 9 outcome measures in the National HIV/AIDS Strategy, 8 can be measured with surveillance data  However, there is a need to  Support and strengthen HIV … surveillance activities: There is a need to support existing surveillance methods to identify populations at greatest risk that need to be targeted for HIV prevention services.
  • 22. Thank you The findings and conclusions in this report are those of the authors and do not necessarily represent the official position o f the Centers for Disease Control and Prevention. National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Division of HIV/AIDS Prevention