John Ioannidis speaking at the XIV Cochrane Colloquium in Dublin, Ireland

1. Plenary 3 Co-chairs: Sally Green and Helen Whelton Pembroke

2. The Human Genome Epidemiology Network (HuGENet): making sense of 10,000,000 postulated genetic risk factors John P.A. Ioannidis Department of Hygiene and Epidemiology University of Ioannina School of Medicine, Ioannina, Greece and Tufts University School of Medicine, Boston, USA

6. Counting fish in the sea of gene-disease associations Ioannidis, Trends Mol Med 2003 Candidate analyses 1 quadrillion Investigators >10 Genetic contrasts >10 Subgroups >10 Outcomes >10 Diseases >1000 Gene variants >10000000 Parameter Multiplier

9. Small sample size

10. Small genetic effects Ioannidis , Trikalinos, and Khoury , Am J Epidemiol 2006

12. Epidemiologic Studies/Platforms Analyses and Publications Knowledge Integration Knowledge Dissemination Network of Networks/ P3G Guide Health Services & Inform Public Policy Guide Research Agenda The HuGENet “Road Map”

13. HuGENet “Network of Networks” Nat Genet Jan 2006

16. Non-replicated diminishing effects Ioannidis et al , Nature Genetics 2001

17. Breast cancer: a “null” field for common genetic variants? Ioannidis , JNCI 2006 and Pharoah et al. JNCI 2006

18. The other side: don’t give up early

19. H: heterogeneity R/F: difference in first vs. subsequent D1-D3: small-study bias diagnostics RS/FS: significant findings (with/without first studies) Ioannidis et al, Lancet 2003

20. Succession of early extremes: the Proteus phenomenon Ioannidis and Trikalinos, J Clin Epidemiol 2005

21. Language bias and global science Pan et al. PLoS Med 2005

23. Let us add the environment Hunter D. Nat Rev Genet 2005

25. “ Genomic profiling to promote a healthy lifestyle: not ready for prime time” Haga S et al. Nat Genet 2003

30. Plenary 3 Co-chairs: Sally Green and Helen Whelton Pembroke