Non-Invasive Prenatal Testing (NIPT) is a screening test that looks at small DNA fragments (cell-free DNA (cfDNA)) secreted by the placenta. This is isolated from the mother's blood and can be tested to see if the baby has Down's, Edwards', or Patau's Syndrome.

1. Understanding Non-Invasive
Prenatal Testing (NIPT):
Principles, Benefits, and
Limitations

2. Non-Invasive Prenatal Testing (NIPT) is a
screening test that looks at small DNA
fragments (cell-free DNA (cfDNA)) secreted
by the placenta. This is isolated from the
mother's blood and can be tested to see if
the baby has Down's, Edwards', or Patau's
Syndrome.

3. The NIPT test is a targeted test that
will determine whether the baby is affected
by Trisomy 21 (Down's Syndrome),
Trisomy 18 (Edwards' Syndrome), or
Trisomy 13 (Patau's Syndrome).
The Vanadis NIPT test can also
determine the fetal sex if requested.
What will NIPT detect?

4. All pregnant women can now receive a combined
serum screening test, which includes a blood test
and an ultrasound scan. This test is less sensitive
than NIPT (86% for Down's Syndrome and 80%
for Edwards' and Patau's Syndromes).
The NIPT is a more accurate test because it is
more than 99% sensitive for Down's and Patau's
Syndromes and 91.7% sensitive for Edwards'
Syndrome.
Why have NIPT?

5. The NIPT test is accessible beginning at 10 weeks of pregnancy.
NIPT has been added to the NHS screening pathway for Down’s
syndrome, Edwards’ Syndrome, and patau's syndrome.
The test is appropriate for both single and twin pregnancies (Please note
that for non-identical twin pregnancies, the NIPT test will provide the
chance of a Trisomy affected pregnancy for the pregnancy and will not
be able to provide a twin-specific opportunity)
The test is appropriate for IVF pregnancies (including donor egg
pregnancies)
The test is appropriate for surrogate mothers.
Who can have the NIPT test?

6. The NIPT test is not suitable if you have cancer or
chromosomal abnormalities including Trisomy 13, 18 and 21
NIPT cannot be performed in multiple pregnancies greater than
twins
NIPT cannot be performed if you have had an organ transplant
or received stem cell therapy or immunotherapy within the last
12 months
NIPT cannot be performed if you have had a blood transfusion
with the last 3 months
Who cannot have the NIPT test?

7. The NIPT test can determine the sex of your baby with
99.6% sensitivity
How accurate is the Vanadis NIPT test for Fetal Sex Determination?

8. The test is performed by taking a
small sample of the mother’s blood.
which is then sent to Concepto
Diagnostics for assessment. The test
is safe for both mother and baby
is the NIPT TEST SAFE test?

9. Thank you
Concepto Diagnostics
https://www.conceptodiagnostics.co.uk/