This study examined the effects of a new energy drink called MonaVie (MV) on exercise performance, cognitive function, and mood compared to a placebo. 25 subjects consumed either MV or a placebo drink and then performed a treadmill exercise test while heart rate was monitored. They also completed reaction time, memory, and mood tests. While some measures like memory were better with MV, most results did not significantly differ between drinks. The study was limited by its small sample size and short duration. Larger and longer term studies are needed to fully evaluate MV's effects.

1. SCIENCE HAS
FOUND A HOME
AT MONAVIE

2. MonaVie 2005
Dr. Alex Schauss

3. SAB Formed 2008
• Dr. Alex Schauss
• Dr. Penny Kris-Etherton
• Dr. Nathan Wong
• Dr. Stephen Talcott
• Dr. Bernie Landes

4. SAB Expands 2010
• Dr. Paul Clayton

5. MonaVie’s Commitment
to Science
• Demonstrated commitment to high quality research
• Basic and clinical studies:
 MonaVie Pulse® (cardiovascular health)
 MonaVie Active® (antioxidant protection/joint mobility)
 MonaVie Emv® (energy/cognition)
 MonaVie (M)mūn® (immune function)
 MonaVie RVL™ (weight management)
• A company respected by the scientific community
• Over 60 funded studies — 15 published in peer reviewed
journals

6. Basic Research
• Understanding The
unique health benefits of
Açai and other
nutraceuticals used in
MonaVie Products
®

7. THE YEAR
OF SCIENTIFIC
DISCOVERIES

8. False Claims on Maqui Berry’s
ORAC Value
• Maqui berry’s ORAC score: Several companies have
claimed that the is significantly higher than açai’s.
• Turns out the claim is false! The lab did not perform the
test.
• Lab responded:
• ―We tried to reach ―company‖… to remove the false
information from their website and materials…this kind of
misinformation is frustrating.‖
• ―Spoke to company. They will remove it.‖

9. Published Açai Research
in PubMed1994-2005
• Up to 2003: 0 citations
• 2004: 2 citations
• 2005: 4 citations
• 2006: 7 citations
• 2007: 9 citations
• 2011: 79 citations

10. 2006-2010: Publications on Açai
Research and MonaVie Stream into the
Scientific Literature
• 2006: Schauss AG, et al. Federation of American dSocieties in Experimental Biology Journal 20: A145.
• 2006: Schauss AG, et al. Journal of Agricultural and Food Chemistry 54: 8598-8603.
• 2006: Schauss AG, et al. Journal of Agricultural and Food Chemistry 54: 8604-8610.
• 2006: Schauss AG. Acai (Euterpe oleracea): An Extraordinary Antioxidant-Rich Palm Fruit.
• 2007: Schauss AG, et al. Proceedings of the Second International Symposium on Human Health Effects of Fruits and Vegetables, Houston, Texas, pp.
39-40.
• 2007: Schauss AG. Acai (Euterpe oleracea): An Extraordinary Antioxidant-Rich Palm Fruit. First foreign translation of English edition.
• 2008: Jensen GS, et al. Journal of Agricultural and Food Chemistry 56: 8326-8333.
• 2008: Honzel D, et al. Journal of Agricultural and Food Chemistry 56: 8319-8325.
• 2008: Schauss AG. Symposium on Flavor and Health Effects of Small Fruits, Cornucopia, AGFD 95.
• 2008: Schauss AG. Acai (Euterpe oleracea): An Extraordinary Antioxidant-Rich Palm Fruit. Second Edition Second foreign translation of English edition.
• 2009: Schauss AG, et al. Proceedings of the Second International Symposium on Human Health Effects of Fruits & Vegetables. Acta Horticulturae 841:
97-100.
• 2009: Jensen GS, et al. Alternative Therapies in Health and Medicine, 15: S90-S91.
• 2010: Schauss AG. Bioactive Foods in Promoting Health: Fruits and Vegetables. Academic Press: Oxford, pp. 479-490.
• 2010: Schauss AG, et al. Flavor and Health Benefits of Small Fruit. American Chemical Society Symposium Series: Oxford University Press, pp. 213-
223.

11. A Year of Discoveries on Açai
& MonaVie 2010-2011
• 2010: Sun X, et al. Experimental Gerontology 45: 243-251.
• 2010: Kang J, et al. Food Chemistry 122: 610-617.
• 2010: Schauss AG, et al. Toxicology 278: 39-45.
• 2011: Chenghui X, et al. Atherosclerosis 216: 327-333.
• 2011: Kang J, et al. Food Chemistry 128: 152-157.
• 2011: Jensen GS, et al. Journal of Medicinal Food, Epub ahead of print.
• 2011: Chenghui X, et al. Journal of Nutritional Biochemistry, under
review.
• 2011: Kang J, et al. Submitted for publication.
• 2011: Poulose SM, et al. Submitted for publication.
• 2011: Schauss AG. Submitted for publication.

12. 2006-2011 Presentations at
Scientific Conferences
• 2006: Schauss AG, et al. Federation of American Societies in Experimental Biology, San
Francisco, CA. FASEB Journal 20: A145.
• 2007: Schauss AG, et al. Proceedings of the Second International Symposium on Human
Health Effects of Fruits and Vegetables, Houston, Texas.
• 2008: Schauss AG. 236th American Chemical Society National Meeting, Division of
Agricultural and Food Chemistry Symposium on Flavor and Health Effects of Small
Fruits, Philadelphia, PA.
• 2009: Schauss AG, et al. North American Research Conference on Complementary &
Integrative Medicine, Minneapolis, MN.
• 2010: Schauss AG, et al. Annual Meeting of the Society of Toxicology, Salt Lake City, UT.
• 2010: Kang J, et al. Federation of American Societies in Experimental Biology, Anaheim, CA.
• 2011: Xie C, et al. Federation of American Societies in Experimental
Biology, Washington, DC.
• 2011: Kang J, et al. Federation of American Societies in Experimental
Biology, Washington, DC.

13. Discovery
• Safety of MonaVie® juice studied.
• 13 experimental in vitro and in
vivo studies carried out over two
years.
• No evidence of genotoxicity
or toxicity.
• The no observable adverse effect
level (NOAEL) for juice
established.

14. Discovery
• MonaVie® juice given to 48 to
84 year olds for 12 weeks.
• Increased serum
antioxidant status
• Improved range of motion
lower back and both knees
• Improvement in activities
of daily living

15. Discovery
• Açai pulp contains potent
anti-inflammatory and
antioxidant compounds.
• A flavonoid was isolated and
shown to be a potent
compound to help balance
inflammatory mediators.

16. Brain Health and Aging
• As we age, there is a decline in how efficiently our brain
removes toxic proteins and other debris.
• This is function is called autophagy, or simply brain
housekeeping.
• A decline in autophagy is linked to age-related memory
loss, and mental decline.
• As reported in August 2010, in an animal model, it was
discovered that compounds in açai pulp activate autophagy
and remove toxic proteins.
Poulos, et al. Annual Meeting, Am Chem Soc., August, 2010, Boston. Shukitt-Hale, et
al. Annual Meeting, Society Neuroscience, November, 2010.

17. Heart Health Myths
1. It only affects the elderly.
2. It doesn’t affect children.
3. It doesn’t affect those who are fit and strong.
4. If I had it, I’d feel sick.
5. If my parents didn’t have it, I won’t get it.

18. Discovery
Adding MonaVie juice to the
diet in animal model*:
• Significantly inhibiting formation of
atherosclerotic lesions by nearly 60%
(p<0.001)
Proposed mechanisms of
action:
• Reduced lipid peroxidation
• Increased antioxidant enzymes
• Inhibition of pro-inflammatory
cytokine production

19. New 3rd Edition of Açai Book
translated into:
• Chinese (Traditional)
• French
• German
• Korean
• Polish
• Malaysian
• Thai

20. SCIENCE
IN SUPPORT
OF SALES

21. Applied Research
• Confirming the
benefits of MonaVie®
products as they are
consumed
Essential

22. MonaVie Active
Antioxidant Capacity
• Increase in serum
antioxidants
• Inhibition of lipid
peroxidation

23. MonaVieRVL™ Study Results
Conclusions:
•The study* demonstrated
a statistically significant
improvement in body
mass index, weight and
waist circumference.
* Small pilot study with 36 people for 28 days, in
persons 100% compliant with the RVL weight
management program.

24. Study Results

25. Study Results

26. E mv® Study Results
• No increase in heart rate versus placebo
• Perceived exertion lower with Emv
• Reaction time improved with Emv
• Participants felt more vigorous with Emv
• Significant improvement of 20% in short-
term memory with Emv

27. Testing the Efficacy of a New Energy Drink
Robert Girandola, Ed.D.
University of Southern California, Los Angeles, Ca.
INTRODUCTION METHODOLOGY
The popularity of energy drinks is undeniable. Over the past several years a number of energy A total of 25 volunteer subjects from the University of Southern California were used as subjects. After completion of signed informed consent forms (IRB
drinks and energy shots have been introduced with incredible popularity. The present market approved), they were informed that the study was actually testing two different energy drinks, to determine which one was superior. Prior to reporting to
for energy drinks in the USA is in the multi billion-dollar range. Research as to the efficacy of the laboratory, subjects were given two 9 oz clear plastic, generic bottles of the MonaVie (MV) OR Placebo (P: carbonated Arrowhead water into which
energy drinks has focused on both cognitive abilities as well as performance variables. Several was mixed a red food color dye and half a package of the dietary sweetener, Splenda). The outside of the bottles was marked “A” (MV) or “B”
recent studies have found that subjects had more alertness and performed better in physical (Placebo). Subjects were told to take both bottles home and to consume the contents on ONE of the bottles, one hour prior to reporting to the lab.
tasks, following ingestion of an energy drink. However, others have not found similar Subjects were told not to consume and food or beverages after consuming the experimental fluid, prior to reporting to the laboratory. The subjects diet
improvements. was not monitored but they were encouraged to consume the same diet on the two testing days. We endeavored to test subjects at the same times on the
two testing days.
Since caffeine is the major active ingredient in these energy drinks it is unclear whether the
improvement is related to this substance or other ingredients. In addition, since the caffeine load Upon reporting to the laboratory subjects were given a choice reaction/movement time test as a warm-up/practice. A Polar heart rate (HR) recording
can be substantial, the safety of these energy drinks has been called into question. The strap was attached to the chest and then subjects were asked to walk on the treadmill. Prior to the walk, subjects were shown a chart displaying 8 random
introduction of a new energy drink based upon fruit juices and less caffeine was the stimulus words and were told to memorize as many as they could. For the first 2 minutes speed was 3 mph and 0%grade. At the 3rd minute, grade was increased
resulting in the current research study. to 10% and HR was recorded continuously. At the 9:30 minute subject was shown the Borg scale (Rating of Perceived Exertion [RPE] – 0-10) and
asked to rate his/her level of intensity. Following the exercise, subjects were given the RT/MT test, with the average of 5 trials recorded. After the
MonaVie has developed such an energy drink made up of 80% fruit juices. In addition the subjects toweled off and were seated, they were given a piece of paper and were told to write down as many of the 8 words they could remember.
carbohydrate source was Palatinose, a slower digested and metabolized sugar. The 8.4 oz can Subjects were then administered the Profile of Mood States (POM) to identify the vigor score. This psychological test has been shown to be a reliable
contains 40 g of CHO (22 g sugar and 15 g Palatinose) 160 Calories. Included in the ingredients measure of vigor in both average people and athletes. At the conclusion of the POMS test, subjects were told to write down their subjective feelings after
are: caffeine ( < 60 mg), D-ribose, ginseng, green tea and guarana. ingesting the fluid and after the laboratory exercises.
PURPOSE Statistical Analysis: a paired, 2-tailed, student's T-Test was used to compare the means for each measurement between trials (A: MV) and (B: Placebo).
The present study was designed to determine if a new energy drink would improve Statistical significance was determined at p<0.05.
exercise and cognitive functions in human subjects,
when compared to a placebo.
RESULTS: Means, SD, and T-Test Results for Each Measure Following Exercise & Cognitive Testing RESULTS
The average age of the subjects was 20 yrs. Of the 25, 11 were
females and 14 were males. Average BMI was 22.39 kg/m2 . Heart
rates for the two drinks were 150.52 and 150.16
bpm, respectively, for both days. The HR was an indication that the
exercise intensity was approximately 65-70% of max. The RPE for
the MV drink was 3.90 vs. 4.16 for the placebo condition, a
difference of 6.7%, but this was not statistically significant.
Similarly, the RT/MT values were faster and the POMS vigor score
higher for the MV condition, but neither achieved statistical
significance. Interestingly, the only variable that was statistically
significant was the memory score, 6.00 vs. 5.04 for the placebo
condition.
CONCLUSIONS
We attempted to use both physical and psychological tests to
determine if this new drink improved exercise or cognitive function,
however, based on the data, we were unable to reach any real
conclusions.
With some of the safety concerns regarding current energy drinks
on the market, especially with the large concentration of caffeine in
a relatively small volume, the MV beverage might offer a safer and
healthier alternative. Future research on this energy drink should
focus on a somewhat longer time frame between ingestion and
testing (2 hours) and a more intense and longer bout of exercise.
Acknowledgements:
The author would like to acknowledge
References: Van den Eynde R, van Baelen PC, Portzky M, Audenaert K. The effects of energy drinks on cognitive performance. Tijdschr Psychiatr. 2008:50 (5): 273-81. Alford C, Cox H, Wescott R. The effects of red bull energy drink on human performance and mood. Amino Acids. 2001;
21(2): 139-50. Rahnama N, Gaeini AA, Kazemi F. The effectiveness of two energy drinks on selected indices of maximal cardiorespiratory fitness and blood lactate levels in male athletes. J Res Med Sci. 2010 May; 15(3): 127-32. Astorino TA, Matera AJ, Basinger J, Evans M, Schurman MonaVie for their support of this study.
T, Marquez R. Effects of red bull energy drink on repeated sprint performance in women athletes. Amino Acids. 2011, Apr 3. Higgins JP, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clin Proc. 2010 Nov;85(11): 1033-41. Duchan E, Patel ND, Feucht C. Energy drinks:
a review of use and safety for athletes. Phys Sportsmed. 2010 Jun;38(2): 171-9. Ballard SL, Wellborn-Kim JJ, Clauson KA. Effects of commercial energy drink consumption on athletic performance and body composition. Phys Sportsmed. 2010 Apr;38(1): 107-17. Candow DG, Kleisinger
AK, Grenier S, Dorsch KD. Effect of sugar-free Red Bull energy drink on high-intensity run time-to-exhaustion in young adults. J Strength Cond Res. 2009 Jul;23(4): 1271-5. Ivy JL, Kammer L, Ding Z, Wang B, Bernard JR, Liao YH, Hwang Improved cycling time-trial performance after
ingestion of a caffeine energy drink. Int J Sport Nutr Exerc Metab. 2009 Feb; 19(1):61-78.

28. Studies in Progress
• MonaVie (M)mun —
®
confirming immune
support benefits
• 2nd MonaVie RVL
Clinical Study

29. PRODUCTS
WITH PURPOSE

30. MonaVie Products...
Best in Class
• MonaVie is a cutting edge nutrition
company providing innovative, science-
based products:
• Functional juices of superior
nutrient density and diversity
• Healthier energy drinks
• Scientifically supported weight
management system

31. What Does the Future Hold?
• Searching the world for new ingredients
• Enhance current health benefits
• Create new categories of benefit
• Continuous innovation in
product form, function,
and taste